Hi friends, just sharing the following:

https://www.eurekalert.org/pub_releases/2021-04/mgh-dds041421.php

Diabetes drug shows potential in fighting cancer

Phenformin may have structural and therapeutic advantages over its sister compound metformin for future cancer treatment

MASSACHUSETTS GENERAL HOSPITAL

NEWS RELEASE: 14 APR 2021

BOSTON - The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH).

In a review article in Trends in Cancer, the team presented evidence that immunotherapies such as immune checkpoint inhibitors (which enable T cells to attack and kill cancer cells) in combination with phenformin may also be a promising way to repurpose this diabetic drug as an anti-cancer agent.

https://www.cell.com/trends/cancer/fulltext/S2405-8033(21)00064-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405803321000649%3Fshowall%3Dtrue

Therapeutic Repurposing of Biguanides in Cancer

Published: April 14, 2021

Thanks.

Kimster