Phenformin ---- Anti-diabetic Drug shows Potential in Fighting Cancer
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Diabetes drug shows potential in fighting cancer
Phenformin may have structural and therapeutic advantages over its sister compound metformin for future cancer treatment
MASSACHUSETTS GENERAL HOSPITAL
NEWS RELEASE: 14 APR 2021
BOSTON - The anti-diabetic drug phenformin may prompt stronger cancer-fighting activities than its sister compound metformin, a finding that could have major implications for current and future clinical trials investigating both agents for their anti-cancer potential, according to researchers at Massachusetts General Hospital (MGH).
In a review article in Trends in Cancer, the team presented evidence that immunotherapies such as immune checkpoint inhibitors (which enable T cells to attack and kill cancer cells) in combination with phenformin may also be a promising way to repurpose this diabetic drug as an anti-cancer agent.
Therapeutic Repurposing of Biguanides in Cancer
Published: April 14, 2021