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Need help with dosing - Pancreatic Cancer Stage 4 - Oxibendazole  

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Jan
 Jan
(@jan)
Joined: 5 months ago
Posts: 4
02/07/2020 4:55 pm  

Hi Everyone. I have been reading all the topics and replies and wanted to ask a few questions. I have Pancreatic Cancer stage 4 metastasized to the liver femur T7 spine and who knows what other places as I have not had a recent Petscan. I have tried all the chemotherapies and radiation. I looked all over the internet for oxibendazole and finally purchased Anthelcide EQ Oxibendazole paste for horses. But I have no idea how to take. I was using Panacur C 222mg/g three days a week until I read Oxibendazole was better for Pancreatic Cancer. No Oxibendazole pills anywhere. Can you guide me how to take the oxibendazole paste? Here's what the information says.
The dosage of oxibendazole is 10mg/kg (2.2 lb.) of body weight (15mg/kg for strongyloides). Each mark on the syringe delivers Anthelcide® EQ to treat 100 lb. (67 lb. for strongyloides).
10mg/kg Dosage:
100 lb. Horse: Syringe Mark 100
200 lb. Horse: Syringe Mark 200
400 lb. Horse: Syringe Mark 400
600 lb. Horse: Syringe Mark 600
800 lb. Horse: Syringe Mark 800
1,000 lb. Horse: Syringe Mark 1000
1,200 lb. Horse: Syringe Mark 1200

15mg/kg Dosage:
200 lb. Horse: Syringe Mark 300
400 lb. Horse: Syringe Mark 600
600 lb. Horse: Syringe Mark 900
800 lb. Horse: Syringe Mark 1200
Please, I need to know how to take to be close to the Panacur dose. I weigh 130 pounds.
Jan


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Daniel
(@daniel)
Admin
Joined: 5 years ago
Posts: 844
05/07/2020 2:51 am  

@jan Dear Jan, this is a very challenging question since I never seen the paste and I don't know anyone who used this. But given the circumstance you described (no response to conventional options and no other left) I totally understand why you are willing to try such an unconventional approach. 

Regarding the dose of Oxibendazole, based on the study shared here https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/parbendazole-and-oxibendazole-are-more-effective-compared-to-fenbendazole-and-mebendazole-in-pancreatic-cancer/#post-2726, I would take 15mg/kg/day

In order to reach dose, I would start first with a low dose (maybe 25%) and move step by step to the target dose (15mg/kg/day). I would consider using this in a similar fashion as Fenbendazole but maybe 4-5 days ON and 2-3 days OFF.

These drugs are very difficult to absorb, so I would take them with fats. In addition, these drugs are metabolised by the liver and little will reach the blood level. This is why, in parallel with this I would use Cimetidine (Tagamet) at about 400 to 800mg/day (one hour prior to taking Oxibendazole). If that is not available I would at least drink grapefruit juice 30 minutes prior to taking Oxibendazole (to try to influence the liver function towards reduction Oxi metabolism and increasing its blood levels).

I hope this helps and I totally understand the urgency. So if you need to reflect some more thoughts and address more questions about various treatment options I will do my best to find some time the coming week and have a call to address that.

Please note that all this comes with the Disclaimer o this website.

Kind regards,
Daniel

 

This post was modified 1 month ago by Daniel

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Jan
 Jan
(@jan)
Joined: 5 months ago
Posts: 4
08/07/2020 12:45 am  

Oh my gosh, Daniel. I didn't check yesterday for replies but signed in tonight and here you are! Okay, all you wrote makes total sense to me. I didn't realize these drugs were so poorly absorbed to this extent. I took the 100 push on the big syringe of paste Friday, Saturday and Sunday out of desperation, and that was the 10mg/kg dose. Now I will do as you suggest and use the 15mg/kg dose. It confused me how the Panacur C was simple to take, a little pack of powder a day for 3 days. (222mg per dose once a day). But the info on this horse paste had me too confused by saying it was either a 10 or 15mg/kg amount.  In other words 10 or 15 mg (Oxibendazole) and how to take the approximate same dose as Panache C 222mg (Fenbendazole). The whole reason I changed meds was because it was thought Oxibendazole worked better. I also read a Chemo drug I was taking named Gemzar might work well along with Oxibendazole. The Abraxene chemo i took with the Gemzar has left me with devastating neuropathy. Plus the cancer metastisized fast on those two drugs. But maybe, just maybe my chemo doctor will be willing to have an open mind using Gemzar and my Oxibendazole. I probably won't mention it being for horses, hee.   So I love the idea of grapefruit juice. There's so much you wrote here that I have to go read again to absorb, but I wanted to give you a reply as soon as I could. I am pretty sure you are an angel on earth and just don't know it. Excuse the poor spelling and wording. You've given me hope again and I thank you.   Jan


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Daniel
(@daniel)
Admin
Joined: 5 years ago
Posts: 844
08/07/2020 1:07 am  

@jan Dear Jan, you are very kind. It's all of us here that we are doing our best to help. This is what brings us together here. Please give me the exact schedule of your current chemo (and chemo type - you already mentioned Gemcitabine) and I will try to mention a few more ideas.

Kind regards,
Daniel 


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Jan
 Jan
(@jan)
Joined: 5 months ago
Posts: 4
08/07/2020 2:15 am  

@daniel   Okay Daniel, I am not currently taking any chemo. My Oncologist went on vacation for two weeks and missed our phone chat appointment before he left, having his physician's assistant call me instead. She knew nothing of my situation and when i explained i was debilitated by the peripheral neuropathy from the Abraxane and more chemo at this time would literally make it impossible to function, she said, oh i understand. Of course at this point i had been all  ready to talk to my oncologist about combining the Gemcitabine with Oxibendazole, sending him your link explaining how they work together, but that was not to be. It's really frustrating sometimes. At that point, I was also getting radiation on my spine at T7. And that Friday before he left I was suppose to start a whole new regimen of different chemo cocktail which I could not do. So to make a long story short, I have a phone appointment with him again next Tuesday so I start again trying to get through to him. I am not on any chemo at this time. Thanks so much.  Jan 


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Jan
 Jan
(@jan)
Joined: 5 months ago
Posts: 4
11/07/2020 11:54 pm  

@daniel   Hello, Daniel. I hope you are well.  I have a quick question. Would Famotidine Pepcid AC 20mg (I have this in my cabinet) work the same as the Tagomet, or is there something unique about Tagomet? It's just that I haven't been in a store for a while with the pandemic. I do have someone going for me next week. Also, know I've been taking Protonix Pantoprazole 40mg once daily for bad regurg. Thanks, Daniel... I know you are so busy and I so appreciate you.  Jan


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Daniel
(@daniel)
Admin
Joined: 5 years ago
Posts: 844
13/07/2020 1:38 am  

@jan Dear Jan,

I checked and

- "Famotidine is metabolized by the hepatic cytochrome P450 system, but has minimal inhibitory effects on the metabolism of other drugs" https://www.ncbi.nlm.nih.gov/books/NBK548228/

- Cimetdine is still the most suitable but here you will fin a list with other drugd that can inhibit similar liver enzymes as Cimetidine https://www.aafp.org/afp/2007/0801/p391.html

I understand the challenge you are going through and its my pleasure to answer asap. So if there are other questions, please let me know.

Kind regards,
Daniel


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Daniel
(@daniel)
Admin
Joined: 5 years ago
Posts: 844
13/07/2020 1:41 am  
Posted by: @jan

@daniel   Okay Daniel, I am not currently taking any chemo. My Oncologist went on vacation for two weeks and missed our phone chat appointment before he left, having his physician's assistant call me instead. She knew nothing of my situation and when i explained i was debilitated by the peripheral neuropathy from the Abraxane and more chemo at this time would literally make it impossible to function, she said, oh i understand. Of course at this point i had been all  ready to talk to my oncologist about combining the Gemcitabine with Oxibendazole, sending him your link explaining how they work together, but that was not to be. It's really frustrating sometimes. At that point, I was also getting radiation on my spine at T7. And that Friday before he left I was suppose to start a whole new regimen of different chemo cocktail which I could not do. So to make a long story short, I have a phone appointment with him again next Tuesday so I start again trying to get through to him. I am not on any chemo at this time. Thanks so much.  Jan 

Hi Jan,

Have you see and considered to use this in combo with Gemcitabine? https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/stage-4-pancreatic-cancer-to-complete-remission-using-paricalcitol-and-hydroxychloroquine-next-to-chemo/#post-1756

Kind regards,
Daniel


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