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Fluvastatin suppresses lung adenocarcinoma by disrupting lactate efflux through MCT4 inhibition

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(@aml)
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Tumor cell-derived microparticles packaging monocarboxylate transporter4 inhibitor fluvastatin suppress lung adenocarcinoma via tumor microenvironment remodeling and improve chemotherapy

https://doi.org/10.1016/j.cej.2022.138972

The following study elucidated the potential inhibitory effect of statins on MCT4-mediated lactate transport, and Fluvastatin was revealed to have the lowest IC50 value.

Inhibitory effects of statins on human monocarboxylate transporter 4

https://doi.org/10.1016/j.ijpharm.2006.02.043

 


   
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