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Fenbendazole vs. Mebendazole

Joined: 1 year ago
Posts: 1
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I have ovarian cancer and had three chemotherapy treatments with Avastin and Neulasta then the debulking surgery and another 3 chemo treatments with Avastin and Neulasta.  I have no BRCA 1 or 2 mutations (hereditary or tumor).  Based on the Foundation Medicine Report, I am HRD negative, TP53 R248W mutation, LYN, PlM1 and TERC amplifications.  I have been on Joe Tippen’s protocol since late February 2020.  My question concerns Fenbendazole (FZ).  Do you if FZ will kill the ovarian cancer cell root?  Or, should I take mebendazole or a combination of both?  If mebendazole, how much to take daily?  Do you know if FZ will suppress the TP53 mutation?  I heard that mebendazole is more effective on TP53 mutation.  I also read that the difference between Fenben and Meben is 1 atom for patent purposes. The part that is effective against cancer is effective in both.  This information is from a PhD chemist.

My oncologist said there are no therapies or clinical trials for my setting.  The oncologist is recommending continuation of Avastin every three weeks and niraparib (Zejula) daily.  I am aware of the serious side effects with Zejula.

Your opinion is greatly appreciated.


Joined: 3 years ago
Posts: 146

I would combine both mebendazole and fenbendazole, they are well tolerable possibly due to their low bioavailability. I would not be afraid to increase the doses and combine them with cimetidine which will help increase the bioavailability of both.

Kind regards

Daniel liked
Joined: 2 months ago
Posts: 2

@manuone I have a few questions regarding bioavailability. For example, if you combine cimetidine with fenbendazole, does the bioavailability of the fenbendazole decrease if you also take other supplements at the same time?

Joined: 3 weeks ago
Posts: 1

I’m just starting to use Fenbendazole for metastatic prostate cancer. Any suggestions as to the protocol and dosage I should use?

Joined: 3 years ago
Posts: 573



Hi, Daniel wrote a comprehensive post on this protocol: