Daniel,
I have ovarian cancer and had three chemotherapy treatments with Avastin and Neulasta then the debulking surgery and another 3 chemo treatments with Avastin and Neulasta. I have no BRCA 1 or 2 mutations (hereditary or tumor). Based on the Foundation Medicine Report, I am HRD negative, TP53 R248W mutation, LYN, PlM1 and TERC amplifications. I have been on Joe Tippen’s protocol since late February 2020. My question concerns Fenbendazole (FZ). Do you if FZ will kill the ovarian cancer cell root? Or, should I take mebendazole or a combination of both? If mebendazole, how much to take daily? Do you know if FZ will suppress the TP53 mutation? I heard that mebendazole is more effective on TP53 mutation. I also read that the difference between Fenben and Meben is 1 atom for patent purposes. The part that is effective against cancer is effective in both. This information is from a PhD chemist.
My oncologist said there are no therapies or clinical trials for my setting. The oncologist is recommending continuation of Avastin every three weeks and niraparib (Zejula) daily. I am aware of the serious side effects with Zejula.
Your opinion is greatly appreciated.
Corkeyjo
I would combine both mebendazole and fenbendazole, they are well tolerable possibly due to their low bioavailability. I would not be afraid to increase the doses and combine them with cimetidine which will help increase the bioavailability of both.
Kind regards
@manuone I have a few questions regarding bioavailability. For example, if you combine cimetidine with fenbendazole, does the bioavailability of the fenbendazole decrease if you also take other supplements at the same time?
I’m just starting to use Fenbendazole for metastatic prostate cancer. Any suggestions as to the protocol and dosage I should use?
Hi, Daniel wrote a comprehensive post on this protocol:
https://www.cancertreatmentsresearch.com/fenbendazole/
Best,
Can Fenbendazole and Mebendazole be taken together at the same time?
Hi @okeyokeh,
I think this may be a good idea. The only challenge may be when both are taken at high daily dose, as that may come with side effects. When taking about 200mg of each daily, I would not expect important side effects. However, even in this case, I would not start with taking them both, but I would first introduce one and after several days I would introduce the other one and observe if there is any adverse reaction.
Kind regards,
Daniel
- Hi, I believe I have colon and stomach cancer. I would like to start a protocol of fenbendazole, but I'm not sure if it interacts with the one medication I'm on. Its called Clonidine Hcl. I cant find info anywhere and I really need to start?
Fenbendazole and Mebendazole compound belong to the class of organic compounds known as benzimidazolylcarbamic acid esters. These are aromatic heteropolycyclic compounds that contain a carbamic acid ester group, which is linked to a benzimidazole moiety.
Benzimidazoles List: https://go.drugbank.com/categories/DBCAT000800
| Drug | DRUG DESCRIPTION |
|---|---|
| AGN-201904 | Agn 201904 has been used in trials studying the prevention of Peptic Ulcer. |
| Albendazole | A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. |
| Albendazole oxide | Not Annotated |
| Astemizole | A second generation antihistamine used to treat allergy symptoms. |
| Bendamustine | An antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. |
| Cambendazole | Not Annotated |
| Dabigatran | Dabigatran is the active form of the orally bioavailable prodrug dabigatran etexilate. |
| Dabigatran etexilate | An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation. |
| Dexlansoprazole | A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. |
| Dexrabeprazole | A proton pump inhibitor indicated in the treatment of gastroesophageal reflux disease and gastrointestinal ulcers. |
| Domperidone | A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. |
| Droperidol | A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. |
| Esomeprazole | A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion. |
| Fenbendazole | Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... |
| Flubendazole | Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. |
| Ilaprazole | Ilaprazole has been investigated in Helicobacter Infections. |
| Lansoprazole | A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. |
| Mebendazole | A benzimidazole anthelmintic used to treat helminth infections. |
| Mibefradil | For the treatment of angina and high blood pressure. |
| Nocodazole | Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules. |
| Omeprazole | A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection. |
| Oxfendazole | Oxfendazole is a sulfoxide metabolite of fenbendazole. This benzimidazole antihelminthic protects livestock from roundworm. strongyles, and pinworn. |
| Pantoprazole | A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid. |
| Pimozide | An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. |
| Rabeprazole | A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. |
| Telmisartan | An ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure. |
| Thiabendazole | A benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections. |
| Triclabendazole | An anthelmintic drug used to treat fascioliasis. |
Carbamates List: https://go.drugbank.com/categories/DBCAT000770
| DRUG | DRUG DESCRIPTION |
|---|---|
| Albendazole | A benzimidazole anthelmintic used to treat parenchymal neurocysticercosis and other helminth infections. |
| Albendazole oxide | Not Annotated |
| Bethanechol | A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. |
| Carbaryl | A medication used in shampoo to remove lice. |
| Carisoprodol | A centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions. |
| Cobicistat | A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. |
| Darunavir | A HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection in patients with history of prior antiretroviral therapies. |
| Diethylcarbamazine | An anthelmintic used to treat filarial infections like Wuchereria bancrofti and Loa loa. |
| Disulfiram | A carbamate derivative used to treat alcohol addiction. |
| Ditiocarb | A chelating agent that has been used to mobilize toxic metals from the tissues of man and experimental animals. It is the main metabolite of DISULFIRAM. |
| Ditiocarb zinc | Ditiocarb Zinc is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... |
| Emylcamate | Not Annotated |
| Ethyl N-methylcarbamate | Not Available |
| Felbamate | An anticonvulsant used to treat severe epilepsy. |
| Fenbendazole | Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect. It is used against a number of gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, the Taenia genus of tapeworms,... |
| Flubendazole | Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. |
| Ganstigmine | Investigated for use/treatment in alzheimer's disease. |
| Mebendazole | A benzimidazole anthelmintic used to treat helminth infections. |
| Mebutamate | Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a... |
| Meprobamate | An anxiolytic drug used for the short-term management of anxiety symptoms. |
| Methocarbamol | A CNS depressant indicated with rest, physical therapy and other treatments to control the discomfort associated with various acute musculoskeletal conditions. |
| NOX-700 | Investigated for use/treatment in diabetes mellitus (type 2). |
| Phenserine | For the treatment of Alzheimer's disease (AD). |
| Physostigmine | A cholinesterase inhibitor used to treat glaucoma and anticholinergic toxicity. |
| Posiphen | Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen® in Subjects With Early Alzheimer's Disease). |
| Rivastigmine | A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. |
| Tetramethylthiuram monosulfide | Not Annotated |
| Thiram | Thiram may be used in dermatology as a scabicide . Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for... |
| Tolciclate | Not Annotated |
| Tolnaftate | An antifungal agent used to treat various skin infections caused by fungi. |
| Urethane | Urethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963. |
| Zafirlukast | A leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma. |
| Zinc dibutyldithiocarbamate | Zinc dibutyldithiocarbamate is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6... |
This is a really interesting fourm and I am thrilled to have stumbled across it... I have been using ivermectin as profalactic against covid, and learned of its "cousins" Fenbendazole & Mebendazole while researching... Prior to the covid mess, I got diagnosed with terminal pancreatic cancer (sept 2019) it was the BRCA2 version, I survived 23 chemos and did have a very good response with chemo, and a bunch of non standard additional treatments... Now I did start profalaxing with ivermectin to stop covid in mid 2020, I take about 1 teaspoon of the liquid stuff and to the best of my knowledge never had covid and never got vaxed... The Mobeen vid that explains how the vax interferes with the BRCA segment of the immune system pretty much iced the cake for me...
Now fast forward to oct 2022, I continue to do well, pancreatic cancer seems to be in remission, I have always been into fitness and proper diet, all of a sudden I go on a trip, and it seems I now have symptoms similar to myocarditus... (I think a recently boosted friend "shed" vax on me) even the slightest physical exertion leads to shortness of breath, kinda a chest pounding sensation and fatigue... Bloodwork is however right on my cancer baseline, test for tropinin shows "4" (acceptable is 0-17) I did a d-dimer, it is negative, Interestingly my Red Blood Cell count, which has always been chronically low (I think its because I used to always do 100K bike rides on weekends) I sit at about 3.90 most months. (range should be 4.30 to 5.60) and my platelets are also always low, I clock in around 125 while average should be 140-400.
There is considerable research to show that cancers involve viruses or vice versa, and ivermectin and Fenbendazole & Mebendazole might be much more effective than costly and dangerous chemo drugs, hence the greedy pricks at pharma dont want you to have it....
ONTO MY QUESTION... SORRY FOR ALL THE BACKGROUND...
I think Covid involves parasites of some sort, and extrapolating this I have the heart / lung problem... its like I do any excertion at all and I feel like I am having a heart attack... so now I am looking at Fenben to see if it might be helpful, ..........." What is the dosage for a 220 lbs human"
@peter-em HI Peter. Sorry for not seeing your post earlier to approve it.
Great to hear you are doing well.
Regarding the symptoms you mentioned, Black Cumin Oil, Lipoic acid and Citrus Bergamot may help.
Are you still taking Ivermectin after all this time? If yes, it may make sense to stop that for a while.
Here are two posts I wrote sometime ago on Fenbendazole and Mebendazole that may address your question:
https://www.cancertreatmentsresearch.com/fenbendazole/
Kind regards,
Daniel
