Dear all,
I would like to ask what kind of therapy you would try in the case of a rather fast growing tumor. My mum has had lung cancer NSCLC (EGFR positive) and her progression were rather slow . However last week on CT there was a fast progression in a new area of the lung with a large area affected.
The oncologist would like to do chemotherapy,which we agreed to. However my mum’s platelets are too low and she has chronic hemoptysis and chemotherapy was postponed and we don’t even know whether she will be able to do it. .
Could you please recommend what kind of therapy you would try in this case (possibly NSCLC transformed into faster growing SCLC) . I suppose metabolic blocking would be enough here. Mums cancer is quite spread throughout her lungs after 4 years since diagnosis and we need to try some kind of salvage therapy.
Thanks in advance,
Michal
By salvage therapy I mean something to try with some chance that it would work. We have mifepristone for about a month that we are going to try, but I am looking for some more similar drugs/therapies.
@michalh Sorry to hear about your mother condition. I think, in addition to metabolic therapy, you could also investigate approaches that could result in systemic anti-tumor response. e.g. Abscopal Effect
Thank you both for your replies and links. Some of them I know already, some are new. Mum has already tried taking fenbendazole, maybe we should do it again. She took metformin, berberine and statins but they seemed to cause weight loss so she does not want to go on with them. Anyway, I think that metabolic approach could be weak for us and we need to try something stronger with some probability of working.
The oncologist would like to do chemotherapy,which we agreed to. However my mum’s platelets are too low and she has chronic hemoptysis and chemotherapy was postponed and we don’t even know whether she will be able to do it.
Maybe mistletoe (helixor) could help her deal with chemo.
Combined Tamoxifen and Gefitinib in Non-Small Cell Lung Cancer Shows Antiproliferative Effects:
https://pubmed.ncbi.nlm.nih.gov/20005069/
The HDAC Inhibitor Trichostatin A Inhibits Growth of Small Cell Lung Cancer Cells
https://www.sciencedirect.com/science/article/pii/S0022480406011802
Sorry for bombarding you with so many links!
"PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma"
https://stm.sciencemag.org/content/12/527/eaax3772
Enviroxime is a potent and specific inhibitor of PI4KIIIβ
"after just 20 min, significant levels of enviroxime were detected in the lungs and noses of exposed mice" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC172302/
PI3K inhibitors together with a ketogenic diet or SGLT2 inhibitors have shown promise (also in human subjects): https://www.cancer.gov/news-events/cancer-currents-blog/2018/pi3k-resistance-ketogenic-diet-diabetes-drug
I would try targeted therapy
