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Dozens of non-oncology drugs can kill cancer cells

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(@daniel)
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Researchers tested approximately 4,518 drug compounds on 578 human cancer cell lines and found nearly 50 that have previously unrecognized anti-cancer activity. These drugs have been used to treat conditions such as diabetes, inflammation, alcoholism, and even arthritis in dogs. The findings suggest a possible way to accelerate the development of new cancer drugs or repurpose existing drugs to treat cancer. https://www.sciencedaily.com/releases/2020/01/200120113130.htm

And here is the original article recently published in Nature: 

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling https://www.nature.com/articles/s43018-019-0018-6


   
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(@daniel)
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"Perhaps most interesting was our observation that the drug tepoxalin has the unique ability to inhibit cells that express high levels of the multidrug resistance gene ABCB1. While tepoxalin was originally developed as a cyclooxygenase/5-lipoxygenase inhibitor, our structure–activity relationship studies clearly showed that tepoxalin’s anticancer activity is probably cyclooxygenase- and 5-lipoxygenaseindependent. While we showed that ABCB1 is both necessary and sufficient to confer tepoxalin cytotoxicity, the precise mechanism by which such cell death occurs is to be established. Further optimization of tepoxalin against this new target, and engineering out the drug’s cyclooxygenase/5-lipoxygenase inhibitory activity, would probably result in improved tolerability as an anticancer agent" https://www.nature.com/articles/s43018-019-0018-6.pdf

Acting against MDR1 expressing cancer cells makes Tepoxalin very interesting!

Tepoxalin is a nonsteroidal anti-inflammatory drug (NSAID). It was originally a candidate for use in humans but was subsequently developed only for dogs.

I am glad I found a study where Tepoxalin was used on humans as it indicates the doses used. I attached the article here.


   
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(@manuone)
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@daniel

Very interesting Daniel!
Without a doubt, the possible "most effective" combination against cancer is found in the combination of reused drugs. Many of them not yet discovered


   
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(@daniel)
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@manuone

Thanks for your reaction Manuel. This is indeed very relevant one as its effectiveness seems to be correlated with MDR expression. The higher the expression, the higher it's anti cancer effectiveness.


   
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 gmt
(@gmt)
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@daniel

Hello Daniel, Thank you for your extensive work on this forum.  You had mentioned in your earlier post that Oxibendazole is easily available online but I am not able to see it online.  Can you please share what is the brand names it is available under and where online ? Thanks.


   
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(@daniel)
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@gmt

Hi Gmt. Here is one example https://www.torsineen.com/product/oxantel-5-100-tablets/

Kind regards,
Daniel


   
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 gmt
(@gmt)
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Thanks Daniel. It seems oxibendazole (oxantel 5) and Fenbendazole is not available where I am.  However Mebendazole tablets are readily available.  Could Mebendazole have efficacy in the case of Pancreatic cancer or is the benefit of Mebendazole restricted to some other cancers only  but not pancreatic cancer ? Also, what might be a effective dosage of Mebendazole in this case ?


   
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(@daniel)
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@gmt

Hi Gmt,

In my experience, everything is available everywhere if we really want it. Given that Mebendazole has low toxicity profile and may be relevant to any type of cancer based on the mechanisms we know, I would try Mebendazole as a part of a more comprehensive approach. Regarding the dose, the minimum that has been used and produced results was 200mg/day. Personally, I would take more, at least 400/day maybe even 1g/day. But I would never jump to that dose. Instead I would increase it step by step. Here is the post I wrote on Mebendazole https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/ and here is a kind man reporting on the dose his son used as a part of a clinical trial. They used doses as high as 4.5g/day and found it safe even at that level https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/#comment-9642

I hope you are also considering this https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/stage-4-pancreatic-cancer-to-complete-remission-using-paricalcitol-and-hydroxychloroquine-next-to-chemo/#post-1756

Kind regards,
Daniel


   
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 gmt
(@gmt)
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Thanks Daniel.  Yes, I have seen your post on Mebendazole which was what introduced me to the compound. It is great all the work you do here. I have seen the other links as well. I am not yet on any treatment since the news is very recent and I have further tests to do. But I have started Mebendazole today. I have also ordered Fenbendazole (Panacur C) which will take me a few days to receive.

Meanwhile I am thinking about diet that could slow the progression.   Have you seen any research about diet that might be beneficial in the case of pancreatic cancer ?  Thanks.


   
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