It has been known for a while that changing the time of chemotherapy administration can affect survival of cancer patients. Even the simple intervention of housing mice in a blue tinted box versus clear box changed melatonin levels which resulted in marked delay in tumor growth (PMID:26678364). Dexamethasone injections and heat shock in a melanoma model also delayed tumor growth (PMID:28196531).
I would love to know if metabolic medicine could also incorporate this. If cancer cells don't get the metabolic message they might be especially vulnerable when the rest of the body goes to sleep.
What effect would changing time of dose administration of 3-BP/metformin etc. have on efficacy?