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White Button Mushroom --- Prostate Cancer


Kimster
(@kimster)
Joined: 1 year ago
Posts: 114
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Hi friends, just sharing the following here:

 

https://www.eurekalert.org/pub_releases/2021-03/tes-wbm031621.php

White button mushrooms could slow progression of prostate cancer

NEWS RELEASE: 20 MAR 2021

Mouse study suggests mushrooms may suppress androgen receptor activity

 

WASHINGTON--The chemicals present in white button mushrooms may slow the progression of prostate cancer, according to a mouse study presented virtually at ENDO 2021, the Endocrine Society's annual meeting.

"Androgens, a type of male sex hormone, promote the growth of prostate cancer cells by binding to and activating the androgen receptor, a protein that is expressed in prostate cells," said lead researcher Xiaoqiang Wang, M.D., Ph.D., M.B. (A.S.C.P.), of the Beckman Research Institute of City of Hope, a comprehensive cancer center in Duarte, Calif.

"White button mushrooms appear to suppress the activity of the androgen receptor."

 

City of Hope's Shiuan Chen, Ph.D., the principal investigator of this project, previously conducted a phase one clinical trial of white button mushroom powder in patients with recurrent prostate cancer, which indicated that the mushrooms reduced levels of prostate-specific antigen (PSA) in the blood, with minimal side effects.

Heightened blood levels of PSA in men may indicate the existence of prostate tumors.

 

The new study aimed to understand the mechanism behind this finding.

The researchers studied the mushroom extract's effect on prostate cancer cells that were sensitive to androgen.

They also studied the extract's effect on mice implanted with human prostate tumors, which creates an animal model whose results would be more reliable as the research is translated to human clinical trials.

The researchers found that in prostate cancer cells, white button mushroom extract suppressed androgen receptor activity.

They also found that in mice treated with white button mushroom extract for six days, prostate tumor growth was significantly suppressed, and levels of PSA decreased.

 

"We found that white button mushrooms contain chemicals that can block the activity of the androgen receptor in mouse models, indicating this fungus can reduce PSA levels," Wang said.

"While more research is needed, it's possible that white button mushrooms could one day contribute to the prevention and treatment of prostate cancer."

 

Thanks.

Kimster


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Daniel
(@daniel)
Admin
Joined: 6 years ago
Posts: 1021
 

Thanks a lot Kimster! It's great to see that they found the mechanism responsible for the anti-cancer activity in prostate cancer.

Here is a video related to the very good results they obtained many years ago in a small clinical study with prostate cancer patients using White button mushrooms powder https://www.youtube.com/watch?v=8mmHJGRsOR0

Have a nice Sunday!

Kind regards,
Daniel


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Kimster
(@kimster)
Joined: 1 year ago
Posts: 114
Topic starter  

Hi friends, just sharing the following here:

 

https://www.cityofhope.org/news/phase-2-mushroom-powder-tablets

City of Hope opens Phase 2 clinical trial to test if intake of mushroom-powder tablets could slow the progression of prostate cancer

April 29, 2021

Scientists investigate if City of Hope’s natural supplement derived from white button mushroom could lower prostate-specific antigen levels, an indicator of prostate cancer.

 

Phase 2 clinical trial - is now recruiting patients - to investigate whether pills containing white button mushroom extract could regulate the immune system, affecting prostate-specific antigen (PSA) levels to either remain stable or decline.

Heightened levels of PSA in men may indicate the existence of prostate tumors.

 

Shiuan Chen, Ph.D., the Lester M. and Irene C. Finkelstein Chair in Biology, has been investigating the potential beneficial effects of white button mushroom (Agaricus bisporus) at City of Hope for about 20 years.
His translational preclinical and clinical research has found that this “bioactive food” available in most supermarkets might prevent or slow the spread of prostate and breast cancers.
The common fungus appears to block the activity of dihydrotestosterone (DHT), a strong form of the male hormone.
 
“White button mushroom — like green tea, turmeric, soybean, rosemary and tomato — has been considered a ‘superfood’ with positive effects on human health,” said Chen, co-investigator of the clinical trial.
“What we’re trying to do is scientifically prove whether the hype is true.
If white button mushroom can slow the progression of prostate cancer, we want to know what the active agent is and what biological mechanisms are at work.”
 
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Results from the Phase 1 white button mushroom trial indicated that white button mushroom extract is safe and potentially effective against prostate cancer.
About 36% of study participants had some decline in PSA levels after three months of white button mushroom tablet intake, and no dose-limiting toxicities were observed.
There were no negative side effects.
Androgen deprivation therapy, on the other hand, is an approved therapy with side effects including fatigue, weight gain, muscle weakness, hot flashes, loss of libido, increased risk of diabetes and cardiovascular problems — all these side effects, yet androgen deprivation therapy is not curative.
White button mushroom consumption seemed to stimulate the immune system into action and limited the growth of prostate cancer cells.
Upon further research in the laboratory, City of Hope scientists found that white button mushrooms contain chemicals that can block the activity of the androgen receptor in animal models, indicating this common fungus could reduce PSA levels.
This research was recently published in The Journal of Nutritional Biochemistry.
 
The objective of the Phase 2 trial is to assess if recurrent prostate cancer patients experience any PSA reduction at three months.
The experimental groups will consume 14 grams of the mushroom-powder tablet per day — roughly 2/3 of a container of white button mushrooms purchased from the supermarket.
Tablets will be prepared from freeze-dried powder of white button mushrooms.
Those in the control group (observation only) will be able to receive the mushroom tablet after three months.
 
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Thanks.
Kimster

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