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Using nitroglycerin to treat prostate cancer shows potential to halt disease


Shanti
(@shanti)
Joined: 5 years ago
Posts: 56
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We are looking at adding low dose nitroglycerin patches to our current regimen:

Using nitroglycerin to treat prostate cancer shows potential to halt disease

https://www.sciencedaily.com/releases/2010/02/100209091844.htm

"The men were treated with a low-dose, slow-release nitroglycerin skin patch and their PSA levels monitored. Of the 17 patients who completed the study, all but one showed a stabilization or decrease in the rate of cancer progression, as measured by their PSA Doubling Time."

 

Phase II Study of Nitric Oxide Donor forMen With Increasing Prostate-specific Antigen Level After Surgery or Radiotherapy for Prostate Cancer https://www.ncbi.nlm.nih.gov/pubmed/19476985


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Daniel
(@daniel)
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Thanks a lot Shanti for sharing! Nice results. I haven't seen this before although is 10 years old.

Here is a nice review on the same compound by Anticance Funds https://www.ncbi.nlm.nih.gov/pubmed/26435741


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Shanti
(@shanti)
Joined: 5 years ago
Posts: 56
Topic starter  

@daniel

Hi D-

Thanks for taking the time to post this additional paper.  Of note is that the dose used in the prostate cancer studies was a patch delivering a continuous microdose of 0.79mg nitroglycerin/day. This is in contrast to the large 10-25mg/day patches used in the NSCLC studies, which were combined with chemo and mostly given just in the days surrounding chemo. 

The primary objective in the NSCLC studies seems to be enhanced drug delivery, whereas the prostate cancer study may be a mechanism of using nitroglycerin to keeping the tumor "happy" with blood flow and oxygen to keep it from turning more aggressive.  That is my initial take.

Best to you! -Shanti


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