supplements  

  RSS

johan
(@johan)
New Member
Joined: 1 year ago
Posts: 66
15/07/2019 12:06 am  

https://www.cancertreatmentsresearch.com/prostate-cancer/#comment-8625

Hi Shanti,
It's impossible to know if the rise in PSA has anything to do with discontinuing the supplement plan, but at least the rise in PSA can't be attributed to those supplements. The fact he took those supplements for an extended period of time without a rise in PSA does add confidence the supplement cocktail is(was) beneficial. That said, the PSA levels now continue to rise after reintroducing the supplements.

As mentioned in my previous reply below(or above), there's a case to be made to exclude apigenin and resveratrol from the supplement plan or to use in rotation (for example one or two months on/off).
In combination with Artemisinin, Resveratrol does seem to produce synergy in anticancer activity. PMID: 25048878

When taking Coq10, consider adding β-glucan.

Combination Therapy with Glucan and Coenzyme Q10 in Murine Experimental Autoimmune Disease and Cancer. PMID: 29848676

When taking lycopene, consider adding sulforaphane.

Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas: https://www.ncbi.nlm.nih.gov/pubmed/17213256

A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. PMID: 25431127

Consider adding IP6

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
http://cancerpreventionresearch.aacrjournals.org/content/6/1/40

Consider taking Magnesium

Magnesium Chloride increases apoptosis and decreases prostate cancer cells migration
https://www.ffhdj.com/index.php/ffhd/article/view/368/699

Honokiol + Artemisinin synergy
https://www.researchgate.net/publication/285726504_Experimental_studies_of_honokiol_in_combination_with_artemisinin_on_anti-tumor_effect_of_SPC-A-1_cells_in_vitro

Consider using liposomal curcumin, in addition or to rotate with the turmeric juice.

Consider adding flax seeds to his diet.

Best Regards,
Johan

This topic was modified 2 months ago by johan

Quote
johan
(@johan)
New Member
Joined: 1 year ago
Posts: 66
15/07/2019 12:17 am  

regarding apigenin, in this study, apigenin stimulated MCF7 cell growth at low concentrations (1 mumol/L), 


ReplyQuote
Shanti
(@shanti)
New Member
Joined: 2 years ago
Posts: 25
15/07/2019 12:53 am  

Hi Johan,
Great information. The addition of the b-glucan to the CoQ10 is indeed compelling and I especially appreciate the link to the info on sulforaphane as it is a clinical trial, anything that could reduce or slow PSA rise makes sense to add in. Hubby actually uses ground flax daily, and I forgot to put it on his list, but he does take 150mg magnesium bisglycinate daily, more than that leads to intestinal side effects. I ordered Honopure and plan on adding it in once I've gotten the other aspects of his protocol in place. He tends to react to things, so I have to add them in one at a time.

I have had hesitancies with sulforaphane in the past because of its ability to increase glutathione, I have the same concerns with the mitochondrial protection afforded by ALA, PQQ and CoQ10, so if we switch to a more oxidative focus, we may consider removing these.

Thank you again for your help!


johan liked
ReplyQuote
johan
(@johan)
New Member
Joined: 1 year ago
Posts: 66
15/07/2019 1:27 am  

You're welcome, Shanti. If magnesium leads to stomach upset or intestinal side effects, you might want to consider magnesium oil transdermal.


ReplyQuote
Shanti
(@shanti)
New Member
Joined: 2 years ago
Posts: 25
15/07/2019 1:28 am  

Thank you for the link to the apigenin information. I suppose prostate cancer could manipulate its alph-estrogen receptor to use apigenin to its advantage (I wouldn't put anything past cancer), but since the info on prostate cancer seems thus far positive, we opted to continue with the apigenin: https://www.ncbi.nlm.nih.gov/pubmed


johan liked
ReplyQuote
Shanti
(@shanti)
New Member
Joined: 2 years ago
Posts: 25
15/07/2019 1:30 am  

Yes, good solution for the magnesium, thank you.


ReplyQuote
Shanti
(@shanti)
New Member
Joined: 2 years ago
Posts: 25
15/07/2019 1:33 am  

The sulforaphane dose used in the study you provided was 200umol, I found this useful conversion calculator: https://www.graphpad.com/quickcalcs/moleform.cfm
Which gives a dose equivalent of 35mg sulforaphane per day. That is doable.


ReplyQuote
johan
(@johan)
New Member
Joined: 1 year ago
Posts: 66
15/07/2019 1:36 am  

@shanti

thanks for that link to the calculator, so useful!!


Shanti liked
ReplyQuote
johan
(@johan)
New Member
Joined: 1 year ago
Posts: 66
20/07/2019 10:44 pm  

In the OP I mentioned the possible synergy between honokiol and artemisinin. Additional synergistic effects might be obtained combining ART and sodium butyrate.

Also, Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer

 


ReplyQuote
Shanti
(@shanti)
New Member
Joined: 2 years ago
Posts: 25
21/07/2019 7:08 pm  

Hi Johan,
Thank you for thinking of me and providing this additional information. I will take a look. Hope you are enjoying the weekend.
Warmly,
Shanti


johan liked
ReplyQuote
Share: