It's impossible to know if the rise in PSA has anything to do with discontinuing the supplement plan, but at least the rise in PSA can't be attributed to those supplements. The fact he took those supplements for an extended period of time without a rise in PSA does add confidence the supplement cocktail is(was) beneficial. That said, the PSA levels now continue to rise after reintroducing the supplements.
As mentioned in my previous reply below(or above), there's a case to be made to exclude apigenin and resveratrol from the supplement plan or to use in rotation (for example one or two months on/off).
In combination with Artemisinin, Resveratrol does seem to produce synergy in anticancer activity. PMID: 25048878
When taking Coq10, consider adding β-glucan.
Combination Therapy with Glucan and Coenzyme Q10 in Murine Experimental Autoimmune Disease and Cancer. PMID: 29848676
When taking lycopene, consider adding sulforaphane.
Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas: https://www.ncbi.nlm.nih.gov/pubmed/17213256
A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. PMID: 25431127
Consider adding IP6
Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Consider taking Magnesium
Magnesium Chloride increases apoptosis and decreases prostate cancer cells migration
Consider using liposomal curcumin, in addition or to rotate with the turmeric juice.
Consider adding flax seeds to his diet.
regarding apigenin, in this study, apigenin stimulated MCF7 cell growth at low concentrations (1 mumol/L),
Great information. The addition of the b-glucan to the CoQ10 is indeed compelling and I especially appreciate the link to the info on sulforaphane as it is a clinical trial, anything that could reduce or slow PSA rise makes sense to add in. Hubby actually uses ground flax daily, and I forgot to put it on his list, but he does take 150mg magnesium bisglycinate daily, more than that leads to intestinal side effects. I ordered Honopure and plan on adding it in once I've gotten the other aspects of his protocol in place. He tends to react to things, so I have to add them in one at a time.
I have had hesitancies with sulforaphane in the past because of its ability to increase glutathione, I have the same concerns with the mitochondrial protection afforded by ALA, PQQ and CoQ10, so if we switch to a more oxidative focus, we may consider removing these.
Thank you again for your help!
Thank you for the link to the apigenin information. I suppose prostate cancer could manipulate its alph-estrogen receptor to use apigenin to its advantage (I wouldn't put anything past cancer), but since the info on prostate cancer seems thus far positive, we opted to continue with the apigenin: https://www.ncbi.nlm.nih.gov/pubmed
The sulforaphane dose used in the study you provided was 200umol, I found this useful conversion calculator: https://www.graphpad.com/quickcalcs/moleform.cfm
Which gives a dose equivalent of 35mg sulforaphane per day. That is doable.
In the OP I mentioned the possible synergy between honokiol and artemisinin. Additional synergistic effects might be obtained combining ART and sodium butyrate.