Metabolomics-based ...
 
Notifications
Clear all

Metabolomics-based phenotypic screens for evaluation of drug synergy via direct-infusion mass spectrometry

1 Posts
1 Users
2 Likes
112 Views
johan
(@j)
Joined: 4 years ago
Posts: 1191
Topic starter  

Using a cancer drug library, we validated the drug screening, integrating isotope-enriched metabolomics data and computational data mining, on a panel of prostate cell lines and verified the synergy between CB-839 (Telaglenastat) and docetaxel both in vitro (three-dimensional model) and in vivo. The proposed unbiased metabolomics screening platform can be used to rapidly generate phenotype-informed datasets and quantify synergy for combinatorial drug discovery.

https://www.cell.com/iscience/pdf/S2589-0042(22)00491-6.pdf

 


   
medline and medline reacted
Quote
Share: