A novel function of geranylgeraniol in regulating testosterone production
A recent study https://www.tandfonline.com/doi/abs/10.1080/09168451.2017.1415129?scroll=top&needAccess=true&journalCode=tbbb20 shows that Geranylgeraniol, a substance found in plants but also produced by the cells in the human body, via the mevalonate pathway, can regulate the steroidogenesis pathway and as a result trigger the production of testosterone and progesterone.
Based on this, it may make sense for the cancer prostate patients to add to their treatment strategy approaches to reduce Geranylgeraniol.
Geranylgeraniol, and ways to reduce that via medication and diet, has been recently discussed here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/
Indeed, Forskolin, a natural plant extract that is derived from geranylgeranyl pyrophosphate is used in the lab to increase levels of cyclic AMP by stimulation of adenylate cyclase in laboratory, which in turn is known to regulate steroidogenesis. This would make me expect that Forskolin would induce testosterone increase in humans. After a little research here I found a study showing that indeed Forskolin ingestion leads to increased Testosterone https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2005.162