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Dehydroascorbic acid as an anti-cancer agent  

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J
 J
(@na)
Joined: 2 years ago
Posts: 525
08/04/2020 1:25 am  

Dehydroascorbic acid is an oxidized form of ascorbic acid.

https://www.ncbi.nlm.nih.gov/pubmed/18378072

"Three discoveries together point the way to a potential treatment for cancer. In 1982, Poydock and colleagues found that dehydroascorbic acid has the remarkable ability to eliminate the aggressive mouse tumours, L1210, P388, Krebs sarcoma, and Ehrlich carcinoma. In 1993, Jakubowski found that cancer cells (but not normal cells) contain measurable quantities of homocysteine thiolactone. Recently, the author found that dehydroascorbic acid reacts with homocysteine thiolactone converting it to the toxic compound, 3-mercaptopropionaldehyde. Taken together, these findings suggest that rapidly-dividing tumour cells make unusually large amounts of homocysteine thiolactone and that administered dehydroascorbic acid enters the cells and converts the thiolactone to mercaptopropionaldehyde which kills the cancer cells. The effectiveness of dehydroascorbic acid might be further increased by combining it with methionine and/or methotrexate to increase the homocysteine concentration in cancer cells."

 

 


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J
 J
(@na)
Joined: 2 years ago
Posts: 525
08/04/2020 5:25 am  

very useful video on how to make your own DHA:

https://youtu.be/YHKBhz7OCB4


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Daniel
(@daniel)
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09/04/2020 1:04 am  

@johan Hi Johan,

 

Very nice and interesting video! Thanks a lot! This makes me think that it's interesting the concept in which we could add AA+DHA+Liposomal version. Each would be absorbed via different mechanisms and therefore lead to high levels of AA in the blood via oral administration.

Triggered by your link, I did some research and look what I found:

Unexpected Early Response in Oral Bioavailability of Ascorbic Acid https://www.townsendletter.com/article/online-unexpected-oral-vitamin-c-response/

According to this study published in March 2020, there is a huge absorption peak of AA in the first minutes after oral admin that is typically not seen by the studies looking at longer time frames.

Kind regards,
Daniel


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J
 J
(@na)
Joined: 2 years ago
Posts: 525
09/04/2020 3:12 am  
Posted by: @daniel

@johan Hi Johan,

 

Very nice and interesting video! Thanks a lot! This makes me think that it's interesting the concept in which we could add AA+DHA+Liposomal version. Each would be absorbed via different mechanisms and therefore lead to high levels of AA in the blood via oral administration.

 

I think that's a brilliant idea D., there seem to be many (anticancer) benefits to such an approach.

The results of the study you mention are important, and I must say I'm not surprised. 

I had forgotten about the DHA video, I saw it 4 or 5 years ago, and I actually made a batch of DHA back then, with the peels of zucchini ( I think peels of cucumber are also OK, but zucchini is best). Worked exactly as shown in the video. The study in the original post then reminded me of it.


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Manuone
(@manuone)
Joined: 2 years ago
Posts: 123
09/04/2020 4:13 pm  

Very interesting thanks for sharing johan!
Precisely Daniel I have published on that subject in the thread of vitamin c!


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Daniel
(@daniel)
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Posts: 895
09/04/2020 4:30 pm  

@manuone Yes Manuel, I just responded to your valuable comment 🙂


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Inabari
(@inabari)
Joined: 2 years ago
Posts: 43
09/04/2020 6:26 pm  

@manuone

 

Hi, 

 

I'm sorry to write this comment out of the thread context. Could I be in contact with you? I'm from Spain and I'd like to email you. My email is Argoitia dot gmail.com 

Thank you 

 

Iñaki 


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