@kati1983

Dear Kati,

I am so sorry you have to go through this at this age. I hope you will be better and better soon.

I have two (long) answers for you. First will be more specific and will post it as part of this msg, and the next one is more general, a comment that I responded to someone else on breast cancer but it will be helpful to you too.

Regarding your question, as I understand Sacituzumab is a targeted chemo (metabolite of Irinotecan) https://en.wikipedia.org/wiki/Sacituzumab_govitecan. As a rule, I would stop anything that could slow down cancer cells, 3 days prior to chemo. Using Fenbendazole after that or before but stop 3 days prior to chemo should help and should not have any negative interference in my view, based on the mechanisms I am aware of. The dose used by Joe and discussed in the post I wrote on Fenbendazole should be suitable regardless of the weight.

In addition, when dealing with TNBC, here is what I would consider the following:

If surgery is planned, I would consider the following:

1. Using Chloroquine at 500mg/week (that means ~2 capsules/week) for 4 weeks will reduce the chance of metastatsis due to surgery 

Reference: Preventing invasive breast neoplasia with chloroquine  https://cancerres.aacrjournals.org/content/77/13_Supplement/CT140  

2. Using Ketorolac prior to surgery is known to reduce cancer recurrence. It is important to discuss that with the surgeon. Watch this video  https://www.youtube.com/watch?v=H8zVrYEW8vE&feature=youtu.be

Reference 1: Potential Benefit of Intra-operative Administration of Ketorolac on Breast Cancer Recurrence According to the Patient's Body Mass Index  https://www.ncbi.nlm.nih.gov/pubmed/29718396

Reference 2: Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery  https://www.ncbi.nlm.nih.gov/pubmed/24464611  

Reference 3: Presented by Dr. Vikas P. Sukhatme: A Simple, One-Time, Inexpensive and Non-Toxic Intervention to Improve Cancer Survival  https://www.youtube.com/watch?v=H8zVrYEW8vE&feature=youtu.be  

To possibly improve the current treatment I would consider one of the following approaches:

1. A light combo of repurposed drugs and supplements:

Repurpused drugs:

- Metformin 1000mg/day (starting first week with 500mg/day and moving up to 1000mg/day after one week)

- Atorvastatin 80mg/day (starting with 40mg/day and moving up to 80mg/day after two weeks)

- Mbendazole 200mg/day or Fenbendazole as discussed here  https://www.cancertreatmentsresearch.com/fenbendazole/

Supplements:

- Omega 3, minimum 3g/day - if the one from fish is not good you can also find the one produced from other sources

- HCA 1500mg/day

- Lycopene 120mg/day

- Quercetin 2g/day

- Vitamin D3 5000ui/day

- Milk Thilste 500mg/day

- Boswellia serrata 3000 mg/day

All should be stop 2-3 days before chemo and restarted with chemo, step by step. If surgery, Omega 3 has to be stopped due to blood thinning effects.

2. A more intensive combo of repurposed drugs and supplements:

Repurpused drugs:

- Metformin 1000mg/day (starting first week with 500mg/day and moving up to 1000mg/day after one week)

- Atorvastatin 80mg/day (starting with 40mg/day and moving up to 80mg/day after two weeks) - a even better statin is discussed here  https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/

- Mbendazole 200mg/day and/or Fenbendazole as discussed here  https://www.cancertreatmentsresearch.com/fenbendazole/

- Doxycicline 100mg/day

- Auranofin 3mg/day and after two weeks 3mg 2x/day as used in CUSP protocol  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/

- Propanolol - the dose is discussed here but it has to be verified with the medical doctor if heart status allows to be taken  https://www.cancertreatmentsresearch.com/propranolol-hexokinase-2-inhibiton-a-similar-anticancer-mechanism-as-that-of-3-bromopyruvate-3bp/

Supplements:

- Omega 3, minimum 3g/day - if the one from fish is not good you can also find the one produced from other sources

- HCA 1500mg/day

- Lycopene 120mg/day

- Quercetin 2g/day

- Vitamin D3 5000ui/day

- Milk Thilste 500mg/day

- Probiotics

- Boswellia serrata 3000 mg/day

All should be stop 2-3 days before chemo and restarted with chemo, step by step. If surgery, Omega 3 has to be stopped due to blood thinning effects.

Other points:

Bisphosphonate - may help to reduce the chance for bone mets - did the oncologist implemented that? Other intravenous treatments such as 2DG metronomic could be discussed separately.

You may also want to check with the oncologist the possibility of using the following 3 drugs:

Bicalutamide

Here is a case of a heavily pretreated woman with metastatic TNBC and AR expression who achieved a complete clinical response after 4 months of treatment with the AR antagonist bicalutamide.

According to this article and case report, complete response could be obtained in some triple negative breast cancers when the patinet is treated with a common drug used for prostate cancer called Bicalutamide. Bicalutamide is a androgen receptor antagonist and it seems that 10% to 32% of the triple negative breast cancers have androgen receptors that can be targeted by Bicatulamide.

Reference: Complete Response of Metastatic Androgen Receptor–Positive Breast Cancer to Bicalutamide: Case Report and Review of the Literature  http://ascopubs.org/doi/full/10.1200/jco.2013.49.8899

Estradiol

Another form of estrogen receptor — called estrogen beta — is present in 25 percent of triple-negative tumors, as well as in over 30 percent of estrogen receptor-positive breast cancer tumors. Research showed that the estrogen receptor beta is a tumor suppressor, which correlates with better patient outcomes.

"Remarkably," claims Hawse, "we discovered that estradiol, which normally stimulates [the] growth of cancer cells in tumors that express estrogen receptor alpha, has the opposite effect in triple-negative breast cancer."  https://www.medicalnewstoday.com/articles/323281.php

Here is the research paper demonstrating the anti-cancer effects of Estradiol: ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis.  https://www.ncbi.nlm.nih.gov/pubmed/30257941

Mayo researchers identify potential new treatment for subset of women with triple-negative breast cancer  https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-identify-potential-new-treatment-for-subset-of-women-with-triple-negative-breast-cancer/

Clofazimine

Towards the first targeted therapy for triple-negative breast cancer: Repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor  https://www.ncbi.nlm.nih.gov/pubmed/30771433  Wnt signaling is overactivated in triple-negative breast cancer (TNBC) and several other cancers, and its suppression emerges as an effective anticancer treatment. However, no drugs targeting the Wnt pathway exist on the market nor in advanced clinical trials. Here we provide a comprehensive body of preclinical evidence that an anti-leprotic drug clofazimine is effective against TNBC. Clofazimine specifically inhibits canonical Wnt signaling in a panel of TNBC cells in vitro. In several mouse xenograft models of TNBC, clofazimine efficiently suppresses tumor growth, correlating with in vivo inhibition of the Wnt pathway in the tumors. Clofazimine is well compatible with doxorubicin, exerting additive effects on tumor growth suppression, producing no adverse effects. Its excellent and well-characterized pharmacokinetics profile, lack of serious adverse effects at moderate (yet therapeutically effective) doses, its combinability with cytotoxic therapeutics, and the novel mechanistic mode of action make clofazimine a prime candidate for the repositioning clinical trials. Our work may bring forward the anti-Wnt targeted therapy, desperately needed for thousands of patients currently lacking targeted treatments.

I hope this helps.

Kind regards,
Daniel

Here is a reply I wrote to someone else sometime ago but it may be relevant to you too:

https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8822

For TNBC I find the following research which is totally great news. Hibiscus flower extract severely induces apoptosis of TNBC Cells. 

I have been drinking Hibiscus Tea/Green Tea mixture on a daily basis, and I really enjoy the tea by itself. Additionally, I take Hibiscus Flower Extracts twice a day as supplements.

https://www.ncbi.nlm.nih.gov/pubmed/31060537

@seyhun Thank you Lovely for sharing this finding!

Kind regards,

Daniel

@daniel hey daniel can i give my mom ketorolac in tablet form because iam afraid that doctor is going to deny giving it prior to surgery. and can you suggest some drugs to take prior to the surgery,to prevent relapse.

Hi @bharat,

Why don't you share with the surgeon the video shared here? https://www.cancertreatmentsresearch.com/community/surgery/nsaids-before-breast-cancer-surgery-can-dramatically-decrease-recurrence/#post-2865

It should take only a little time from him to see and understand, and be able to help many.

Taking Ketorolac prior to surgery without informing the surgeon I think would be a mistake since that can lead to challenging complications during or immediately after the surgery. When the surgeon is aware about that he will know how to manage possible complications, such as bleeding.

Otherwise, I would just start 1-2 weeks after the surgery anti-inflammatory such as Curcumin, Omega 3, Olive Leaf Extract, Aspirin, but also Cimetidine.

Some weeks prior to surgery I would start HydroxyChloroquine, given at a dose of 250mg every 4 days. There are studies suggesting a very good contribution at least in breast cancer bus possible others https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/

Kind regards,
Daniel

@daniel thank you for your reply Daniel,iam confused between hydroxy Chloroquine and simple Chloroquine. can i use any one of them.

Hi @bharat,

Hydroxychloroquine is best due to lower chance for side effects. Here you can find a bit more discussion on hydroxychloroquine https://www.cancertreatmentsresearch.com/chloroquine-hydroxychloroquine/

Kind regards,
Daniel

Thanks for your reply  @daniel, one thing I noticed on that website is they also talked about  "Amodiaquine", and it being more effective among all chloroquine's. I would love to know your take on this daniel.

Hi @bharat,

Actually that website is the same as this one 🙂 cancertreatmentsresearch.com and that is an article I wrote some years ago. I think Amodiaquine is a very relevant one and it is also available and accessible.

Kind regards,
Daniel

Thanks @daniel for reaching me out,my mom is fighting with TNBC,she just had her last chemo and had a great response. I am currently working on relapse protocol for her. I if you have any suggestions please do share.

hey @daniel did you ever hear again from kati after this post. would love to know about her condition.

No @bharat, not even a response to my long answer above.

If you like, I can contact her by e-mail and check if the info above was useful.

Kind regards,
Daniel

Hi @daniel, yeah I think we should try to contact her. At leat we will get to know if she doing well.

hey @daniel have you got any reply from kati?

HI @bharat no answer yet. I will let u know if any. Kind regards, Daniel

@daniel ohh, let's hope everything went fine.

 hey @daniel i am confuse as hell, i want to create a protocol for my but i got  overwhelmed, can you please help me to find best drugs. 

Hi @bharat,

That is normal and this is the learning process. I already shared on this website many of what I think are best drugs and supplements. 

What I can help with is when you have specific questions, or when you have own plan and want feedback on that. When you have that please share here (including all conventional and alternative treatments) and I will share my view on that.

Kind regards,
Daniel

hey @daniel do you heard back from kati, and does taking NSAIDS after one week of gonna have same effect as ketorolac.

and @daniel i made this protocol for my mom, 

berberin (3x500mg);
Mebendazole (1x100mg);
Atorvastatin (1x40mg); Doxycycline(1x100mg perhaps three cycles of 1 month per year);
Propranolol (1x40mg); (imp)
Desloratadine (2x5mg);
Flarin(1x200mg e2d)

adenosine
Methylglyoxal
Dipyridamole

https://www.ncbi.nlm.nih.gov/pmc/articles
/PMC6027968/
Hibiscus flower extract
Gluconate
Graviola
rick simpson oil
asprin

Etolodac
doxycycline

please share views on this. what i can add and what i can take out?

Hi Daniel

This is an amazing forum. Thank you for your contribution. My mom has an oral cancer. Has anyone had success with this? She is 85 and I am not seeing many women in this forum who have used Fenben. I am concerned that perhaps men do better with it then women. Her cancer has moved from inside her left cheeck into her lymph nodes. thank you

 hi @hmehta9358 fenben is great for many type of cancers as it target the metabolic pathways of cancer cell. i had a great success with fenben, i will advise you to go for it. and please consider taking it with vitamin e as it's found that it increases it's action.

Thanks for your response. I am still a little concerned about the dosage. Does the size of the person matter? She weighs 108lbs.

@hmehta9358

no mam, as far as i know i doesn't matter's, and dosage can be in range of 244mg to 1g i have given my mom 300mg of fenben and 200 mg of meben and it worked really well for her.

hi @Daniel  still waiting for you reply.

Posted by: @bharat

and @daniel i made this protocol for my mom, 

berberin (3x500mg);
Mebendazole (1x100mg);
Atorvastatin (1x40mg); Doxycycline(1x100mg perhaps three cycles of 1 month per year);
Propranolol (1x40mg); (imp)
Desloratadine (2x5mg);
Flarin(1x200mg e2d)

adenosine
Methylglyoxal
Dipyridamole

https://www.ncbi.nlm.nih.gov/pmc/articles
/PMC6027968/
Hibiscus flower extract
Gluconate
Graviola
rick simpson oil
asprin

Etolodac
doxycycline

please share views on this. what i can add and what i can take out?

HI @bharat, how did you manage to source Methylglyoxal? 

Kind regards,
dng050

@dng050

hey buddy Methylglyoxal can be found in many natural substances.like manuka honey.

and iam not going to use it because it is not as effective on TNBC compare to  other types of cancers.

@bharat I don't know anything about mebendazole. Where can I read about it? I've started her off half a gram day 1 and 1 gram day 2 of Fenben. What are good painmeds? So far she is on 1000 mg of tylenol 4 times per day and total of 600 mg of gabapentin plus magic mouthwash which numbs the area for an hour or so. Any other suggestions would be helpful.