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Triptolide --- from Chinese herb, Thunder God Vine

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Kimster
(@kimster)
Joined: 3 years ago
Posts: 115
Topic starter  

Hi friends, just sharing the following here:

 

https://www.sciencedaily.com/releases/2020/12/201214164322.htm

Compound derived from thunder god vine could help pancreatic cancer patients

Date: December 14, 2020

Source: The Translational Genomics Research Institute

Summary:
The results of a pre-clinical study suggest how a compound derived from the thunder god vine -- an herb used in China for centuries to treat joint pain, swelling and fever -- is able to kill cancer cells and potentially improve clinical outcomes for patients with pancreatic cancer.

 

The medicinal plant's key ingredient, triptolide, is the basis of a water-soluble prodrug called Minnelide, which appears to attack pancreatic cancer cells and the cocoon of stroma surrounding the tumor that shields it from the body's immune system.

Investigators recently published the study results in the journal Oncogenesis.

 

https://www.nature.com/articles/s41389-020-00285-9

Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts

Published: 09 November 2020

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Triptolide (TPL), a natural compound isolated from the Chinese herb Tripterygium wilfordii (Thunder God vine), has shown promising preclinical antitumor activity against a number of cancers including pancreatic cancer.

The water-soluble pro-drug of triptolide, Minnelide, was recently reported to show promising activity in patients with gastrointestinal malignancies in Phase I clinical trial.

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Thanks.

Kimster

This topic was modified 2 years ago 2 times by Kimster

   
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Daniel
(@daniel)
Admin
Joined: 7 years ago
Posts: 1156
 

Thank you Kim. We discussed this one some months ago https://www.cancertreatmentsresearch.com/community/leukemia/evaluation-of-minnelide-as-a-potential-therapeutic-agent-for-preventing-the-relapse-of-aml/#post-2874

During 2014/2015 I carefully investigated this one and even ordered Triptolide. Very expensive - we never used this due to the expected toxicity.

Kind regards,
Daniel


   
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Kimster
(@kimster)
Joined: 3 years ago
Posts: 115
Topic starter  

@daniel

Hi Daniel, thank you for your reply to this post to share the information on previous discussion, so that we could understand more about Triptolide.

 

Thanks.

Kimster


   
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