Triptolide --- from Chinese herb, Thunder God Vine
Hi friends, just sharing the following here:
Compound derived from thunder god vine could help pancreatic cancer patients
Date: December 14, 2020
Source: The Translational Genomics Research Institute
The results of a pre-clinical study suggest how a compound derived from the thunder god vine -- an herb used in China for centuries to treat joint pain, swelling and fever -- is able to kill cancer cells and potentially improve clinical outcomes for patients with pancreatic cancer.
The medicinal plant's key ingredient, triptolide, is the basis of a water-soluble prodrug called Minnelide, which appears to attack pancreatic cancer cells and the cocoon of stroma surrounding the tumor that shields it from the body's immune system.
Investigators recently published the study results in the journal Oncogenesis.
Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts
Published: 09 November 2020
Triptolide (TPL), a natural compound isolated from the Chinese herb Tripterygium wilfordii (Thunder God vine), has shown promising preclinical antitumor activity against a number of cancers including pancreatic cancer.
The water-soluble pro-drug of triptolide, Minnelide, was recently reported to show promising activity in patients with gastrointestinal malignancies in Phase I clinical trial.
Thank you Kim. We discussed this one some months ago https://www.cancertreatmentsresearch.com/community/leukemia/evaluation-of-minnelide-as-a-potential-therapeutic-agent-for-preventing-the-relapse-of-aml/#post-2874
During 2014/2015 I carefully investigated this one and even ordered Triptolide. Very expensive - we never used this due to the expected toxicity.