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Parbendazole and Oxibendazole are more effective compared to Fenbendazole and Mebendazole in Pancreatic Cancer

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(@daniel)
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A recent study suggests that for Pancreatic Cancer, two other anti-worm drugs from the Benzimidazole-Based Anthelmintic category and used for animals, Parbendazol (brand name Verminum, Worm Guard and Helatac) and Oxibendazole, is more effective compared to Fenbendazole and Mebendazole (Ref.). While Parbendazole seems not to be on the market anymore, Oxibendazole can be easily found online.

The study is available at the link below:

The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer https://www.mdpi.com/2072-6694/11/12/2042/htm

 


   
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(@jcancom)
Joined: 7 years ago
Posts: 625
 

D, I noticed that alibaba has Parbendazole. Parbendazole looks like a very good one; I wonder how other cancer lines might respond. 


   
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(@daniel)
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@jcancom

Thanks J. Good to know we have the Alibaba option. Yes, would be interesting to know what is the activity in other tumor types.


   
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 gmt
(@gmt)
Joined: 4 years ago
Posts: 10
 

@Daniel

Hi Daniel, I noticed in the chart in the paper attached that at the initially low concentrations, Mebendazole can be counterproductive as it seemed to increase cell viability.(AsPC-1 and Capan-2).  How can one convert the drug concentration in the chart - e.g. 1uM to mg to Mebendazole ? I saw your comment sometime back about Mebendazole dosages but I want to understand if there is a way to convert this concentration mentioned in the study to mg dosage ?  

https://www.ncbi.nlm.nih.gov/pubmed/31861153

I have a similar question on Thymoquinone concentration.  The attached article refers to a Thymoquinone concentration of 10-50 uM.  But I don't understand what that means.  What would that be equal to in mg or ml of dosage ?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220391/

Thanks,

Regards,

gmt


   
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 gmt
(@gmt)
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@Daniel  Hi Daniel, could you pls share your thoughts regarding this question.


   
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(@daniel)
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@gmt

You have to know the molar mass (MW)  of e.g. Mebendazole. mass of MBZ in gram = number of mole*MW in gram/mole. So if you know MBZ in µM then multiply it by the MW to get it in µg per L.

If MW is referred in kDa (kilo daltons) you know that 1 kDa = 1000 g/mole

Here is an example of a calculation I deed for Loratadine:

1. I know that in humans, it reaches 26ng/mL at it’s peek

2. And I know it inhibits MCT1 at 61uM

3. So the question is how to compare the two. Here is the calculation to compare the two:

  • 26ng/mL is the same with 26ug/L
  • Loratadine molar mass is 382.88 g/mol
  • 26ug*1mol/382.88g=0.067umol/L or 0.067uM, in other words, this is 67nM

So the max blood level is 67nM while in order to inhibit MCT1 Loratadine needs to reach 61uM, i.e. a much higher level. However, we often cannot compare these since there is also accumulation of drugs inside the cell. So my point is that in most of the cases, the drugs taken orally cannot reach the levels used in the lab, yet they have been observed as effective in humans even at those very small blood levels. 

In conclusion, if I see a good drug or supplement and I know that has led to positive effects in humans, I would take as much as I can and is safe, and move without being stuck too much in to the mathematics.

Kind regards,
Daniel

 


   
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 gmt
(@gmt)
Joined: 4 years ago
Posts: 10
 

@Daniel Thanks Daniel.

 


   
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(@j)
Joined: 6 years ago
Posts: 2160
 
Posted by: @gmt

 

I have a similar question on Thymoquinone concentration.  The attached article refers to a Thymoquinone concentration of 10-50 uM.  But I don't understand what that means.  What would that be equal to in mg or ml of dosage ?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5220391/

Thanks,

Regards,

gmt

Thymoquinone potentiates chemoprotective effect of Vitamin D3 against colon cancer: a pre-clinical finding.

https://www.ncbi.nlm.nih.gov/pubmed/28337306


   
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(@karenlagerberg)
Joined: 4 years ago
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My husband has stage 4 pc and today they stopped chemo and put him in hospice.  He has had whipple surgery in Aug. of 2019.  We asked about taking Fenbendazole and the oncologist said to try it but I read where you are saying oxibendazole may be better.  I cannot find any directions on how to take it or where to purchase it.  Can you help me?  


   
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(@daniel)
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Posted by: @karenlagerberg

My husband has stage 4 pc and today they stopped chemo and put him in hospice.  He has had whipple surgery in Aug. of 2019.  We asked about taking Fenbendazole and the oncologist said to try it but I read where you are saying oxibendazole may be better.  I cannot find any directions on how to take it or where to purchase it.  Can you help me?  

Hi Karen,

I am sorry to hear that. POxi seems to be available as Oxantel used for animals like Fenbendazole https://www.torsineen.com/product/oxantel-5-100-tablets/

I would use same dose as Fenbendazole (222mg/day) 4days ON and 3 days OFF. I would start with a lower dose and move up to 222mg/day step by step since I would not know how that behaves in humans.

Please read the posts here https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/

And also consider Silver in higher dose, which is very easy to implement even in more difficult situations https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/?highlight=silver

Whne you have time please read this, you may get more ideas https://www.cancertreatmentsresearch.com/summary-of-this-website/

 

Kind regards,
Daniel

 

 

 


   
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(@klagerberg)
Joined: 4 years ago
Posts: 1
 

My husband is taking Eliquis, will this be a problem with the Oxibendazole?


   
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(@daniel)
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Posted by: @klagerberg

My husband is taking Eliquis, will this be a problem with the Oxibendazole?

Dear Karen,

There is no information available on that since this is a drug used in animals.

According to this article https://doi.org/10.1016/j.pt.2003.09.007 there is only one trial where Oxibendazole was used in humans performed in China.

Here is the Chinese study https://pubmed.ncbi.nlm.nih.gov/2208619/ According to this, 196 people were treated with Oxibendazole at a dose of 15mg/kg daily, during 3 days. No marked adverse reactions were observed by clinical and laboratory examinations at this dose, which is an important information.

The dose above would indicate a 1g/day daily dose used for a 70kg person.

Beyond this there is no other information on interactions.

However, in order to try to have a feeling on what to expect, knowing that Oxibendazole is very similar to Albendazole which is a drug used in humans, we can check the interaction between Eliquis and Albendazole.

Acording to the drug interaction checker https://reference.medscape.com/drug-interactionchecker?src=google there is no expected interaction between Eliquis and Albendazole.

I hope this helps.

Kind regards,
Daniel

 

 

 


   
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(@janicep)
Joined: 4 years ago
Posts: 1
 

@klagerberg

Hi there.  Is your husband taking the Oxibendazole?  Our naturopath recommended fenbendazole, but I have seen some clinical studies discussing pardendazole as being more effective in Pancreatic cancers.  

 

My husband is also on Eliquis.  

Planning to begin the fenbendazole, as the parbendazole has been difficult to find.  


   
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(@daniel)
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@janicep Hi Janice,

Please also look into this https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/stage-4-pancreatic-cancer-to-complete-remission-using-paricalcitol-and-hydroxychloroquine-next-to-chemo/#post-1756 I would very much considering this approach.

More ideas on Panc Cancer https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/ and here https://www.cancertreatmentsresearch.com/category/cancer-types/

If you use drugs and supplements, consider stopping all a few days before chemo and restarting a few days after chemo.

Kind regards,
Daniel

 


   
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(@suki8889)
Joined: 4 years ago
Posts: 8
 

Hi All. Mom mom has PanCan with mets in her liver. We are based in HK and read about the Joe's protocol. Any idea where I can order Parbendazole and Oxibendazole from? Many thanks! 


   
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(@daniel)
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Joined: 9 years ago
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Hi @suki8889,

I am sorry to hear about the health challenges of your mom. I shared above an example of a drug containing Oxi, that I found online https://www.torsineen.com/product/oxantel-5-100-tablets/ but you should be able to find more.

Please spend more time and read more of the articles on Cancer Treatments Research - you will find more ideas on new treatment options, or options to increase the effectiveness of existing ones.

Kind regards,
Daniel

 


   
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(@suki8889)
Joined: 4 years ago
Posts: 8
 

@daniel Hi Daniel - I've been looking for some Pardendazole on Alibaba as well, as based on your research Parbendazole is more effective then Oxibendazole. I've been told that the powder they sell on Alibaba are active ingredients and not safe for household use? Would it be okay to use if mix with water? Thank you! 


   
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(@suki8889)
Joined: 4 years ago
Posts: 8
 

@jcancom Hi J, did you end up ordering from Alibaba?


   
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(@suki8889)
Joined: 4 years ago
Posts: 8
 

@janicep Did Fenben work for your husband? My mom is at stage 4 Pancan I got her some Fenben and looking into Parbendazole as well


   
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(@jcancom)
Joined: 7 years ago
Posts: 625
 

@suki8889, it is possibly best to stay with the more mainstream treatments that are easier to obtain (e.g., fenbendazole). From a good base treatment, one could then add in enhancers such as DCA etc.. It is surprising that more on forum have not realized the amplifying effect that such synergistic treatments can achieve. 

Best Wishes, J


   
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(@johnhknoblock)
Joined: 3 years ago
Posts: 1
 

Hi Daniel-  Thank you for all of your time and efforts!  You have put out such a huge volume of life-saving information.

My 59 year old wife was diagnosed with inoperable stage 3 pancreatic cancer almost a year ago.  We've gone through the standard of care treatments- folfirinox, gem-abrax, ablative stereotacic radiation.  Good news is small growth but no metastasis and her ca 19-9 came down, but now things are trending up again. The doctors don't want to treat too soon again for fear of chemo resistance. But we're scared to just wait.

A friend steered us to your posts on Oxibendazole.  My wife uses that on her horse for deworming, so she says if it's good for her horse then she wants it too!!!

We just ordered Anthelcide EQ 22.7 Oxibendazole Wormer paste from Stateline Tack (22.7% Oxibendazole).  We're thinking of she's 50 kg so we're thinking 250 mg Oxibendazole three times a day (750mg/d total).  She got some Flax oil to mix it with to help absorption and take it with her Creon pancreatic enzyme pill.

Does that sound right?  Are there any other posts specifically about doing oxibendazole that I missed?  Do you know of any relevant stage 3 clinical trials on that?  We saw the study you citing about combining parabendazole with gemcitabine.  Any knowledge or thoughts about doing that with oxibendazole?

Thank you so much- John and Liz


   
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(@daniel)
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@johnhknoblock

Dear John, 

I am sorry for the delay but I had so many e-mails requesting for help and I need to take it step by step.

There are no other post on Oxibendazole other than here and a few discussions in the comments section of the Fenbendazole post in the Blog area.

Of course, there are many options we can think of, but if it is to focus on anti-parasitics I am thinking the following:

- In the article on Oxi the authors make the following observation: "linear alkylic (parbendazole) or alkyloxy (oxibendazole) chains are preferred as compared to an aryl ring connected through a sulfur (fenbendazole) or a carbonyl (mebendazole) bridge in mediating anti-proliferative effects." https://www.mdpi.com/2072-6694/11/12/2042/htm

- I thought to check if Albendazole is linear or shows a ring. The structure of Albendazole is similar to that of parbendazole and oxibendazole https://en.wikipedia.org/wiki/Albendazole As a result, there is a possibility that Albendazole will also have potential at the same level as parbendazole and oxibendazole. 

- Indeed, I check the literature on Albendazole and Pancreatic Cancer and it seems Albendazole also scores at the top in Pancreatic cancer https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171052 next to Niclosamide and a few others https://doi.org/10.1371/journal.pone.0171052.s003

- Given the fact that Albendazole is easy to access, I would consider adding this one to next to Oxibendazole, and if possible Niclosamide. So I would make a cocktail of 3 antiparasitic drugs.

- I would not start with all at once, but I would add one every several days, starting with 50% of the target dose of each, and moving to 100% after a few days.

I hope this idea helps.

Kind regards,

Daniel


   
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(@joshevans)
Joined: 3 years ago
Posts: 5
 

@daniel Thank you very much for all of the information you provide. It is so very kind of you. My Mom has Stage 4 pancreatic cancer and we have tried many drugs/supplements that are backed with journals and research. Is Niclosamide still available? We are from the United States and it seems it is being phased out? Yomesan seems to be the trade name we see, but everything appears to be discontinued/unavailable. Is there anywhere you know of that we could possibly get it from?

Thank you,

Josh 


   
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(@daniel)
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@joshevans

Hi Josh,

I am sorry to hear about the health challenges of your dear mom and hope she will be well. Niclosamide should be available at pharmacies online and also on eBay. Some online pharmacies are listed here https://www.cancertreatmentsresearch.com/suppliers/

If you like, you can share here the list of supplements, drugs and chemo (including the frequency) that your mom is using, and I will give you my feedback.

Kind regards,

Daniel


   
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(@joshevans)
Joined: 3 years ago
Posts: 5
 

@daniel

 

Thank you very much. My Mom was diagnosed with stage 3 non-resectable (due to vein-artery involvement) pancreatic cancer (adenocarcinoma) in November of 2019. She originally starting with treatment with Folfirinox. Right before staring Folfirinox we had learned about Fenbendazole and about blocking pathways (via How To Starve Cancer book). We were lucky to get the common off label drugs from her primary doctor (all similar prescriptions to what the Care Oncology program works with). She lost quite a bit of weight and the diarrhea was so bad on Folfirinox she had to quit after about 6 cycles. We were very lucky, the CA-19 went down to around 50 and the tumor shrunk by half but it was still not resectable.

 

They then gave her radiation and Capecitabine (Xeloda) in pill form to see if they could get the tumor to fall away from the arteries to possibly attempt the Whipple. After the radiation and chemo pill, the scan did not look much different, we were somewhat disappointed, but it was not worse and we now believe the radiation did more that we initially thought.

 

She was then scheduled to take part in a clinical trial for photo-dynamic light therapy at the Mayo clinic. This sounded very good, but it kept getting pushed back and ended up being canceled due to Covid. We later found out she would not have been a candidate for the trial due to a new tumor being found after having another scan. The new tumor is down around the pelvis. It was biopsied and confirmed pancreatic cancer spread. This was very difficult. We were really hoping the off-label drugs and supplements were holding it. And It was stable at that size for about a year.  

 

She then started Gemcitabine/Abraxane. After completing about 3-4 months of this, it was found via scan it is not working at all and the new tumor has doubled in size. However, the original tumor has actually slightly improved.  

 

Our thoughts are that this new tumor is a newer, smarter version that has found a way to adapt and feed off of the other pathways. Another thought (more so hope) is that the original tumor is dead and there is just the scarring left over. And that the secondary tumor around the pelvis has maybe been there longer that we had thought. 

 

She is now going to do radiation and Capecitabine (Xeloda) in pill form again on this new tumor to see if they can slow it down and keep it from pushing on the rectum and bladder.

 

Through all of this, my brother and I have gotten quite familiar with Pubmed and other academic journals/articles. We understand the issue with pancreatic is the fact the tumor is dense and has the strong outer stroma. The way the tumor forms makes it difficult to even get chemo or other drugs into it. We have researched many things including:

The Stephen Biegleson paricalcitiol/hydroxychloroquine along with gemcitabine and we tried every angle to get the paricalcitol but we could not find any doctors that would entertain the idea. The thought of the paricalcitol penetrating the stroma was very interesting. We have also researched the hedgehog drugs and have seen some very promising ones, but have seen them fail in later trials due to them being deemed "a double edge sword". We have given her a large dose of vitamin d and contemplated trying liposomal vitamin d, but are unsure. We added the high dose vitamin d after learning about the paricalcitol paper, but know we need to be somewhat careful of hypercalcemia. 

 

We also had the molecular profiling done via PANCAN/TEMPUS, but there were no actionable mutations or other helpful data.

 

We have also seen and researched LDN/ALA, RSO, DCA, Anthelmintics in general, anti-fungals (itraconazole), the fermentation theory, inositol+IP6, silver nanoparticles, parp inhibitors, and others.

 

Her drug/supplement schedule that has been pretty consisting through things with the exception of a few things:

 

At Breakfast

Metformin (500 mg)

Hydroxychloroquine (200 mg x2)

Dipyridamole (50 mg)

Atorvastatin (40 mg)

2 grams Fenbendazole

2 Gamma Vitamin E

Sulforaphane

10,000 IU D3

EGCG

 

At Lunch

Doxycycline (100 mg)

2 Curcumin (Highly bio-available)

Claritin

Hydroxycitrate

Ursolic Acid

Resveratrol

Claritin

 

At Dinner

Metformin (500 mg)

1 Hydroxychloroquine (200 mg)

Dipyridamole (50 mg)

Atorvastatin (40 mg)

2 Curcumin (Highly bio-available)

10,000 IU D3

EGCG

 

At Bedtime

Dipyridamole (50 mg)

Milk Thistle

Hydroxycitrate

Ursolic Acid

EGCG

 

We are somewhat unsure what the next step should be, but we were planning to possibly add:

Albendazole

Oxibendazole

DCA

DHEA

Artemisinin

 

We also wonder about itraconazole, niclosamide, menbendazole, sulfasalazine, azithromycin, parbendazole (but only available via Alibaba from very questionable suppliers) and other drugs from the fermentation theory. But we can only get and put her on so many drugs. We feel we are kind of on the edge. Maybe remove some and add others? 

 

What is your opinion of the Metro Map from Jane's book? According to that theory, pancreatic is glutamine driven, but is it possible the new tumor could be feeding of of the glucose PP pathway or aerobic glycolysis? Would you recommend anything in general?

 

Thank you very much,

Josh  


   
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(@joshevans)
Joined: 3 years ago
Posts: 5
 

@daniel

 

I am sorry for such a long message. I just wanted to add she is only 62 years old and she is starting the radiation and chemo pill next week to try and slow down/shrink the new tumor.

 

The time you have put in to write articles and the knowledge you share is so very kind.

 

Thank you very much,

Josh 


   
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(@petro)
Joined: 3 years ago
Posts: 2
 

@joshevans Hello Josh, I am sorry to hear about the health challenges of your mom. My Dad is also going through the same. What dosage of IP6 is she taking. What bland is it? I can share about my father's dosage. We noted a significant improvement with a higher dose IP6 in his case. Three months after starting the treatment, tumor has shrunk by halve and all cancer outside the pancreas is gone. Have you followed the posts by Kerri Landry, a pancreatic cancer survivor on facebook?     


   
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(@daniel)
Admin
Joined: 9 years ago
Posts: 1191
Topic starter  
Posted by: @joshevans

@daniel

 

Thank you very much. My Mom was diagnosed with stage 3 non-resectable (due to vein-artery involvement) pancreatic cancer (adenocarcinoma) in November of 2019. She originally starting with treatment with Folfirinox. Right before staring Folfirinox we had learned about Fenbendazole and about blocking pathways (via How To Starve Cancer book). We were lucky to get the common off label drugs from her primary doctor (all similar prescriptions to what the Care Oncology program works with). She lost quite a bit of weight and the diarrhea was so bad on Folfirinox she had to quit after about 6 cycles. We were very lucky, the CA-19 went down to around 50 and the tumor shrunk by half but it was still not resectable.

 

They then gave her radiation and Capecitabine (Xeloda) in pill form to see if they could get the tumor to fall away from the arteries to possibly attempt the Whipple. After the radiation and chemo pill, the scan did not look much different, we were somewhat disappointed, but it was not worse and we now believe the radiation did more that we initially thought.

 

She was then scheduled to take part in a clinical trial for photo-dynamic light therapy at the Mayo clinic. This sounded very good, but it kept getting pushed back and ended up being canceled due to Covid. We later found out she would not have been a candidate for the trial due to a new tumor being found after having another scan. The new tumor is down around the pelvis. It was biopsied and confirmed pancreatic cancer spread. This was very difficult. We were really hoping the off-label drugs and supplements were holding it. And It was stable at that size for about a year.  

 

She then started Gemcitabine/Abraxane. After completing about 3-4 months of this, it was found via scan it is not working at all and the new tumor has doubled in size. However, the original tumor has actually slightly improved.  

 

Our thoughts are that this new tumor is a newer, smarter version that has found a way to adapt and feed off of the other pathways. Another thought (more so hope) is that the original tumor is dead and there is just the scarring left over. And that the secondary tumor around the pelvis has maybe been there longer that we had thought. 

 

She is now going to do radiation and Capecitabine (Xeloda) in pill form again on this new tumor to see if they can slow it down and keep it from pushing on the rectum and bladder.

 

Through all of this, my brother and I have gotten quite familiar with Pubmed and other academic journals/articles. We understand the issue with pancreatic is the fact the tumor is dense and has the strong outer stroma. The way the tumor forms makes it difficult to even get chemo or other drugs into it. We have researched many things including:

The Stephen Biegleson paricalcitiol/hydroxychloroquine along with gemcitabine and we tried every angle to get the paricalcitol but we could not find any doctors that would entertain the idea. The thought of the paricalcitol penetrating the stroma was very interesting. We have also researched the hedgehog drugs and have seen some very promising ones, but have seen them fail in later trials due to them being deemed "a double edge sword". We have given her a large dose of vitamin d and contemplated trying liposomal vitamin d, but are unsure. We added the high dose vitamin d after learning about the paricalcitol paper, but know we need to be somewhat careful of hypercalcemia. 

 

We also had the molecular profiling done via PANCAN/TEMPUS, but there were no actionable mutations or other helpful data.

 

We have also seen and researched LDN/ALA, RSO, DCA, Anthelmintics in general, anti-fungals (itraconazole), the fermentation theory, inositol+IP6, silver nanoparticles, parp inhibitors, and others.

 

Her drug/supplement schedule that has been pretty consisting through things with the exception of a few things:

 

At Breakfast

Metformin (500 mg)

Hydroxychloroquine (200 mg x2)

Dipyridamole (50 mg)

Atorvastatin (40 mg)

2 grams Fenbendazole

2 Gamma Vitamin E

Sulforaphane

10,000 IU D3

EGCG

 

At Lunch

Doxycycline (100 mg)

2 Curcumin (Highly bio-available)

Claritin

Hydroxycitrate

Ursolic Acid

Resveratrol

Claritin

 

At Dinner

Metformin (500 mg)

1 Hydroxychloroquine (200 mg)

Dipyridamole (50 mg)

Atorvastatin (40 mg)

2 Curcumin (Highly bio-available)

10,000 IU D3

EGCG

 

At Bedtime

Dipyridamole (50 mg)

Milk Thistle

Hydroxycitrate

Ursolic Acid

EGCG

 

We are somewhat unsure what the next step should be, but we were planning to possibly add:

Albendazole

Oxibendazole

DCA

DHEA

Artemisinin

 

We also wonder about itraconazole, niclosamide, menbendazole, sulfasalazine, azithromycin, parbendazole (but only available via Alibaba from very questionable suppliers) and other drugs from the fermentation theory. But we can only get and put her on so many drugs. We feel we are kind of on the edge. Maybe remove some and add others? 

 

What is your opinion of the Metro Map from Jane's book? According to that theory, pancreatic is glutamine driven, but is it possible the new tumor could be feeding of of the glucose PP pathway or aerobic glycolysis? Would you recommend anything in general?

 

Thank you very much,

Josh  

Dear Josh,

Thank you for the details, and sorry for taking more time to respond.

My feedback on the supplements and drugs are the following:

1. Metformin 1-15g/day is good
2. Hydroxychloroquine 200mg 3x/day is too much for longer time - i would go for 200mg only
3. Dipyridamole - no specific opinion
4. Atorvastatin 80mg.day is good (40mg every 12 hours)
5. Fenbendazole - if already used for longer time and no response, I would change to Oxibendazole or Mebendazole at 500mg/day. I would also make sure it comes from a trusted source since I heard of Fenbendazole being sold as high purity but only <10% inside
6. Vitamin E - no opinion
7. Sulforaphane - not very important here, I think 
8. Vitamin D3 - very good
9. EGCG - yes but high enough dose supported by Milk Thisle to maintain the liver 
10. Doxycycline - very important in panc cancer in my view but 200mg/day, 100mg every 12 hours
11. Curcumin - should be Curcumin C3 at 7-8/day combined with Omega 3 high in DHA
12. Claritin - no opinion
13. HCA - very good here
14. Ursolic Acid and Resveratrol - not very important here, I think 

The most important of the above, in my view, have been highlighted with bold.

Increasing the dose of Doxy and Curcumin is important, as well as considering Mbendazole if Fenbendazole is already used for some time.

(Panc Cancer seems to be specifically responding to antibiotics.)

Griseofulvin could be also an interesting one to consider (on the line of microtubule disruptors) since it is acting in the space where panc c responds https://www.cancertreatmentsresearch.com/griseofulvin-like-chemotheraphy-but-without-its-side-effects/

It's a pity we did not speak earlier to discuss what could be used as support for Folfirinox combo or Gemcitabine/Abraxane combo. When taking the repurposed drugs in combo with this chemo its important not only what to take but also when to take them. However, you of course still have many options to consider. In general, I would think that you need to have a strong core treatment here. As a next step, I woudl see radiation as the core treatment since you mentioned that is going to be the next step, while doing Capecitabine in the background.

To support the effectiveness of radiation, one that comes first in my mind is the mihocondria inhibitor Atovaquone (please use the search function in both the Blog section and the Forum section where there is a different search option, to find discussions about this drug). Next to that you may want to pick up some from this post https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/ specifically Sulfasalazine.

Some years ago I met a man with panc cancer stage 4 who had complete response to Diflunisal https://www.cancertreatmentsresearch.com/diflunisal-2/  

If you have any specific question, please let me know. If there are more questions we can organize a phone call (no fee just help).

Kind regards,
Daniel


   
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(@joshevans)
Joined: 3 years ago
Posts: 5
 

@daniel

 

Thank you so much for everything. We appreciate it so very much. 

 

My brother is also very involved with researching and we appreciate everything so much. We might eventually want to take you up on that phone call, we have a list of things we are interested in talking about.

 

Regarding the upcoming radiation and chemo pill treatment, you recommended to stop antioxidants on another section of the forum we saw. Does this include all sources of antioxidants? Such as all curcumin, EGCG, HCA? Or are there some good antioxidants?

 

We have a general practice doctor that has been somewhat helpful and we have been able to get some prescriptions from. We are going to try to get the Atovaquone and Sulfasalazine to start as soon as possible (hopefully before starting the radiation). As well as double the doxycyline dose.

 

Regarding doses, do these seem close?

 
Atovaquone
Atovaquone (250mg tab): gradually increase to 250mg 3x/day.
or Atovaquone (oral suspension): gradually increase to 750 mg (5 mL) 2x/day.
 
Sulfasalazine
Sulfasalazine (500 mg tab): gradually increase to 1000mg 2x/day.

 

And we hope to add Griseofulvin and Diflunisal in the near future. We are currently giving her albendazole and have mebendazole on the way. We are a little concerned about the albendazole and the possible liver issues. We also have oxibendazole.

 

Thank you very much,

Josh      


   
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(@joshevans)
Joined: 3 years ago
Posts: 5
 

@petro

 

Hello, yes I have heard of Kerri Landry's story. I'm very happy to hear there are a handful of stories like hers and that's great to hear about your Dad's improvement on IP6. We just currently started it, IP6 Gold Brand (Powder) and are just taking 1 serving (a little over 5 grams). But we are most likely going to stop it before starting radiation and the chemo pill due to the fact it is a strong antioxidant. What brand and dose is your father taking? Did he take it and get those results during chemo or radiation?

 

Thank you,

Josh


   
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