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Fungi accelerate pancreatic cancer

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Daniel
(@daniel)
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Malassezia fungi—generally found on the skin and scalp—are responsible for dandruff and some forms of eczema have been previously found to be connected to skin and colorectal cancer, and now to pancreatic cancer.

Treatments in mice against Malassezia, using antifungal drug, reduced their pancreatic ductal adenocarcinoma (PDA) tumor weight by 20% to 40% over the 30 weeks. Also, cancer grew 20% faster in the pancreases of mice repopulated with Malassezia, but not in the presence of other common fungal species.

Here is the original paper published in Nature in 2019: The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL https://www.nature.com/articles/s41586-019-1608-2%20

Here is a Nature paper disusing the above results https://www.nature.com/articles/d41586-019-02892-y  


   
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judy D
(@judy-d)
Joined: 2 years ago
Posts: 2
 

I found Valbazen (Albendazole) a broad-spectrum DeWormer.  Is this more effective than Fenben? I searched for hours for Parbendazole and Oxibendazole and Valbazen came up.  Tried to post a photo of the bottle of Valbazen with no success.

Any help/suggestions would be greatly appreciated!


   
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Kimster
(@kimster)
Joined: 3 years ago
Posts: 115
 
Posted by: @judy-d

I found Valbazen (Albendazole) a broad-spectrum DeWormer.  Is this more effective than Fenben? I searched for hours for Parbendazole and Oxibendazole and Valbazen came up.  Tried to post a photo of the bottle of Valbazen with no success.

Any help/suggestions would be greatly appreciated!

Hi judy D, just sharing the following information from this website if(just in case) not yet noticed by you:

 

https://www.cancertreatmentsresearch.com/news/?highlight=albendazole

https://www.sciencedirect.com/science/article/pii/S2213231716301926

The conclusion of this study: “We propose that ABZ induces oxidative stress promoting DNA fragmentation and triggering apoptosis and inducing cell death, making this drug a promising leader molecule for development of new antitumor drugs.”
I indeed know the potential of ABZ and like it for long time, and intend to once write a post on it. It is an over the counter and FDA approved drug – an anti worm medicine, easily accessible (e.g. eBay) and cheap.

 

https://www.cancertreatmentsresearch.com/fenbendazole/?highlight=albendazole

Results: We identified fenbendazole, fluspirilene, clofazimine, niclosamide and suloctidil, which showed selective cytotoxicity on metastatic prostate cancer cells in vitro and in vivo. Such selectivity could explained by differential induction of apoptosis. Upon improvement in bioavailability, fenbendazole and albendazole significantly extended the survival of metastases bearing mice, and the extension of lifespan by albendazole was equivalent or greater than that provided by paclitaxel. These drugs were active in taxane-resistant tumors and in the bone microenvironment, two clinical conditions of men with advanced prostate cancer. Conclusion: Metastatic tumor cells differ in their responses to certain drug classes. Albendazole shows promise as a potential adjunct to standard therapy in patients with metastatic prostate cancer.

 

https://www.cancertreatmentsresearch.com/treating-ascites-with-angiogenesis-inhibitors/?highlight=albendazole

Here are some VEGF inhibitors I know (besides the conventional ones): Baicalein, Noscapine, Mebendazole, Albendazole, Celcoxib, Shark Cartilage, Thalidomide, Curcumin

Here is a nice reference for Albendazole:  Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice. http://www.ncbi.nlm.nih.gov/pubmed/16551879 . The only drawback related to Abendazole is the liver toxicity. On the other hand I know a cancer patient who is taking it for a long time with no major issues.

 

Sorry as just sharing above information, but could not provide information on "Is this more effective than Fenben?".

 

Thanks.

Kimster


   
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judy D
(@judy-d)
Joined: 2 years ago
Posts: 2
 

@kimster

Thank you ..Great information. I am very new at this website.  I am trying to figure out the pathways and what fuels pancreatic cancer. Any/all info is well appreciated.  Thank you!


   
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Daniel
(@daniel)
Admin
Joined: 7 years ago
Posts: 1156
Topic starter  

@judy-d In my mind, one of the most relevant area in pancreatic cancer is related to intracellular cholesterol (import, production, storage). This is why, this perspective may be relevant https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/

There is of course much more to say. What is the patient using at this point as conventional treatment?

Regarding your question above, it's difficult to compare Albendazole, Fenbendazole, and Oxibendazole since all have both common and different anti-cancer mechanisms. In one study Oxibendazole stood out.

I discussed this in other place on this website.

Kind regards,
Daniel


   
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