ovarian cancer gene
 

ovarian cancer gene  

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anca
 anca
(@anca)
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08/05/2017 12:09 am  

My mother is currently undergoing chemotherapy for recurrent ovarian cancer. Someone suggested to me that she should get genetic testing to see if she has the genes that can lead to ovarian cancer, because there is some specific treatment according to the genes and the type of cancer. What is your opinion and your advice, Daniel? Thank you.


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Daniel
(@daniel)
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08/05/2017 7:09 pm  

Hi Anca,

Specifically for Ovarian Cancer you could address this question to Alberto  https://www.cancertreatmentsresearch.com/taurolidine/#comment-4321 who I expect could help you with ideas on this line. The first question would however be if you have a tumor sample that could be investigated. If not, there is another option in which blood sample is taken from your mom and sent to a laboratory such as RGCC  https://www.rgcc-group.com/index.php?page=main#patient They will select circulating tumor cells in the blood and perform a genetic profile of the cells. In this case, besides the general genetic profile they provide relevant to most cancers, they should be able to respond any specific questions you may have including the one above. Such laboratories can also test the most used chemotheraphies against the circulating tumor cells to determine the cell sensitivity to the various tumors. You can contact RGCC and ask who are the doctors in your country working with them. Other similar laboratories in Europe are e.g. Metavectum http://www.metavectum.de, Maintrac http://www.maintrac.de .

Kind regards,
Daniel


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anca
 anca
(@anca)
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19/05/2017 12:54 am  

Thank you for your your detailed answer, Daniel. Apparently, my mother's onchologyst considered she already tested all the chemotherapy medicins for ovarian cancer, she already had Paclitaxel and Carboplatin and she became resistant to them after the recurrence, then she had Gemzar and Avastin and then the doctor tried Paclitaxel, it isn't working and now my mom has Carboplatin in combination with Gemzar every Monday since last week, I hope it works, but my mom lost her energy and became very weak. Do you know if there are other possibile chemotherapies for ovarian cancer? Should she keep a strict diet? Or should she just sleep and rest? Also, we want to do hiperthermie, but we have to take her to Iași and the doctor from there didn't respond yet. It seems that these perithoneal nodules are hard to kill by chemotherapy. But when we asked the onchologyst for a surgery, she replied: "Surgery for what?". So apparently surgery is not an option, maybe because there are more cells spread in different parts of the perithoneum. Thank you so much, Daniel.


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Daniel
(@daniel)
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19/05/2017 8:05 pm  

Hi Anca,

I am sorry to hear your mom is not well after the last chemo combination. Regarding chemo options for ovarian cancer, you could ask Ergin, Alberto and other contributors on this website as they are also dealing with ovarian cancer. A chemosensitivity test may also show you other chemos that may be effective, which may be assigned to other types of cancer today. You can also read my response to Hectoria who is also fighting ovarian cancer https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/#comment-4637

From a diet point of view, given that you may not be able to follow restricted ketogenic diet, I think best is to focus on a diet that does not contain sugar, carbohydrates and avoid red meat due to glutamine. So a vegan-like diet would help.

I recommend to read carefully the comments on this post as you may get some ideas out of it  https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/

It is a pity that the oncologist answered like that. She should explain clearly and in a sensitive manner why surgery is not an option, and what could be the alternatives. Did she mentioned any clinical trial or immuno-therapy as an option?

Kind regards,
Daniel

 


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anca
 anca
(@anca)
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23/05/2017 12:51 am  

Hi Daniel,

My mother's oncologist didn't mention any clinical trial or immuno-therapy as an option. My mother is weaker and her immune system is so weak now that she has a boil like a big bump in the genital region. She also had very low number of platelets: 30,000 and it should be higher than 150,000 and they gave my mother blood plasma because she didn't have enough red cells, so she couldn't have the chemotherpay session today, she will have it on Wednesday. My mother is always tired and she needs to sleep. The family doctor told me that my mother should just take vitamin D and vitamin C, because those mushroomos Coriolus will be "killed" by the chemotherapy, now my mother doesn't want to take the Coriolus either, cause she thinks it is no use if she is under chemotherapy. What do you think about that?

Today in the hospital they gave my mother intravenous vitamin C. Maybe it will help. Since she started Carboplatin again in combination with Gemzar, she is feeling week, sleepy and her immune system is so low. I am thinking about doing this chemosensitivity test, but i don't know how long it takes for such tests to be done.

Today my mother met someone in the hospital, who told my her that she kept a strict vegetarian diet for 2 years and she was feeling weak and the colon cancer came back in the pancreas, and she eats everything now, she is having cancer for 11 years now and had chemotherapy all these years except 2 of them. Now my mother is convinced she can eat everything except sugar and she should eat meat and liver to have more platelets in the blood. I don't know how much the food really matters.

Thank you so much for your kind answer,

Anca

 

 


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E
 E
(@ergin)
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23/05/2017 11:53 pm  

Dear Anca,

I am really sorry to hear about your moms situation.

As you see,we are also trying all possibilities.

You have to think about more serious strategies.

What i learned from chemo is:Platin beats patient.I like Gemzar because less side effects.

But Gemzar alone is not very effective.We have a doctor member here.Dr Masato Hada.

He uses thalidomide+gemzar.After i searched thalidomide and ovarian ca.There is a clinical trial.

Thalidomide works for most.You can think about it.

I know it is impossible to tell it to your dr.I also tried but he didnt accepted.

Some drs fired me from their office.

It is really hard for me to tell you to try drugs.

But if the situation is very serious(here we hate the term terminal) you have very less options.

Then you must think about the strategies that is not very known yet.But sounds very effective.

Salinomycin,3BP,T4 Depletion strategy,Phlorizin+hyperthermia.

What i am trying now is just like this.And i am writing our full protocol in order to help people. https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/#comment-4637

So you can follow it from there.Then  this makes me to feel better if you choose your own way.

Kind Regards

Ergin


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E
 E
(@ergin)
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24/05/2017 12:03 am  

One more thing i forgut to write.There is a low molecular weight heparin called tinzaparin.

Tinzaparin totally reverts platinium- resistive ovarian cancer cells to sensitive again in lab tests in an article.You cannot find any other drug like this.Totaly reverts!!!

But no one tried here or i found on internet.According to the article (lab test)3 day is needed before chemo.They use safely regular heparin and tinzaparin for pulmonary embolism for cancer patients.

But i couldnt find the efficiency of tinzaparin on ovarian cancer cell in human on internet.

 

 


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anca
 anca
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24/05/2017 2:15 pm  

Thank you so much for the answers, Ergin. I also read some of the comments from your page. I will search for Thalidomide and Tinzaparin in Romania. So sorry to hear about your mom, I hope she is better with all these treatments. My mom is worse after April unfortunately, because she had a recurrence in December. I will try hiperthermie, maybe it helps.

 


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anca
 anca
(@anca)
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24/05/2017 10:58 pm  

Hi Ergin,

I  want to try tinzaparin. Could you please tell me how should this be taken, by syringe or intravenous or by capsules?

Kind regards,

Anca

 


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E
 E
(@ergin)
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24/05/2017 11:38 pm  

Dear Anca,

Honestly i didnt believe you at first that you will try those which i mentioned.

This shows me how you believe in science and your affort to save your moms life.

Really my eyes became fill.I dont want to be responsible from any treatment but you look serious.

I have found it on pharmacies as intramuscular type.(Innohep)

But never tried yet.I dont know what to say.Just i searched and found new articles yesterday.

May be you want to look at it.

https://www.google.com.tr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=2&cad=rja&uact=8&ved=0ahUKEwjZm_fGvonUAhWBtRQKHaRjAV4QFggnMAE&url=http%3A%2F%2Fwww.mdpi.com%2F1420-3049%2F22%2F5%2F728%2Fpdf&usg=AFQjCNEGNyZXvNb_Wczc2EpZYoEnqkU_kA

 


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Daniel
(@daniel)
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Joined: 4 years ago
Posts: 302
25/05/2017 12:03 am  

Hi Anca,

Please check with your doctor. In general it should not be any problem, but for some people (and usually cancer patients are special) that may lead to internal bleeding if the dose is too high or if the blood condition is not suitable for using such medication. When fighting cancer we need to act but make sure you reduce the risks as much as you can related to any step.

Kind regards,

Daniel


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anca
 anca
(@anca)
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Joined: 2 years ago
Posts: 18
25/05/2017 12:14 am  

Hi Daniel,

Thank you for showing me the risks. I just wrote two pages of information from your articles and forum and will show it to the doctor. Maybe it will help some other patients.

Kind regards, Anca


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E
 E
(@ergin)
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Joined: 3 years ago
Posts: 134
25/05/2017 12:31 am  

Dear Anca,

We have another member Alberto who is using heparin to his ovarian cancer patient iv.(I think he is doctor)

May be you have to talk with him.

Daniel is totally right,i did not use it for 2 reasons.

1-My mother doesnt take platin.

2-I am afraiding of bleeding

But you can check the clinical trials about heparins and bleeding possibilities with cancer patients.

Internal bleeding is another issue that you have to consider.

And may be you can find a type of tinzaparin which does not have anticoagulant activity which causes 

internal bleeding.(I dont know where you can find)

Why dont you think T4 depletion strategy?

Is your mom hypothyroid(using T4,Levotiron)?

Dear Anca,please tell me how can i help you?

I can understand you too much.Does your mother knows the situation?

Please talk with her, she has to choose her own way.

Dont take too much responsibilities without her permission.

Kind Regards

Ergin

 

 

 

 

 

 

 

 


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anca
 anca
(@anca)
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Posts: 18
26/05/2017 12:48 am  

Hi Ergin,

Thanks for your answer. My mom is hypothyroid as far as I know. She has a bigger problem now, she is under antibiotics for 7 days becuase she has a boil, like a bump in the genital area. Se took the antibiotics for 3 days but she wants to stop them even if she dies from septicemia because the pain in the stomach from the antibiotics is too much to endure, she feels she now has a wound in the stomach due to the antibiotics taken. I don't know how safe it is to stop the antibiotics after 3 days and how much is the risk of septicemia.

 


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Helga
(@helga)
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Posts: 10
26/05/2017 4:37 pm  

Hi Anca,

I responded to you on the other thread but am just wondering: is the boil being helped by the antibiotic? Doctors tend to prescribe it for lack of a better treatment for mostly everything. I had/have a persistent bronchitis for 1-2 years but the doc still prescribed it for me anyway. The pharmacist told me nothing sour taken, not even vitamin C! They like to scare you, I think, makes them feel better about themselves (please, ignore this if your doctor is not like that). I said to the hell with this precaution and did take vitamin C and even citric acid (true, added some sodium bicarbonate) just not around the time I took the antibiotic. It is pathetic not to allow even vitamin C, considering how strongly acidic the stomach itself is. In the end vitamin C helped more than the bloody antibiotic, which I stopped after 6 days.

But if she feels the antibiotic is helping her somewhat, she/you could go back to the doctor and ask another antibiotic or a topical cream. In general, it would be good to strengthen her immune system with some natural substance. E.g. maitake or other mushrooms/extracts are great at it. Also, if she can take vitamin C, that would help a lot, too.

cheers,

Helga


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