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ovarian cancer gene

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anca
 anca
(@anca)
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My mother is currently undergoing chemotherapy for recurrent ovarian cancer. Someone suggested to me that she should get genetic testing to see if she has the genes that can lead to ovarian cancer, because there is some specific treatment according to the genes and the type of cancer. What is your opinion and your advice, Daniel? Thank you.


   
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Daniel
(@daniel)
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Hi Anca,

Specifically for Ovarian Cancer you could address this question to Alberto  https://www.cancertreatmentsresearch.com/taurolidine/#comment-4321 who I expect could help you with ideas on this line. The first question would however be if you have a tumor sample that could be investigated. If not, there is another option in which blood sample is taken from your mom and sent to a laboratory such as RGCC  https://www.rgcc-group.com/index.php?page=main#patient They will select circulating tumor cells in the blood and perform a genetic profile of the cells. In this case, besides the general genetic profile they provide relevant to most cancers, they should be able to respond any specific questions you may have including the one above. Such laboratories can also test the most used chemotheraphies against the circulating tumor cells to determine the cell sensitivity to the various tumors. You can contact RGCC and ask who are the doctors in your country working with them. Other similar laboratories in Europe are e.g. Metavectum http://www.metavectum.de, Maintrac http://www.maintrac.de .

Kind regards,
Daniel


   
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anca
 anca
(@anca)
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Topic starter  

Thank you for your your detailed answer, Daniel. Apparently, my mother's onchologyst considered she already tested all the chemotherapy medicins for ovarian cancer, she already had Paclitaxel and Carboplatin and she became resistant to them after the recurrence, then she had Gemzar and Avastin and then the doctor tried Paclitaxel, it isn't working and now my mom has Carboplatin in combination with Gemzar every Monday since last week, I hope it works, but my mom lost her energy and became very weak. Do you know if there are other possibile chemotherapies for ovarian cancer? Should she keep a strict diet? Or should she just sleep and rest? Also, we want to do hiperthermie, but we have to take her to Iași and the doctor from there didn't respond yet. It seems that these perithoneal nodules are hard to kill by chemotherapy. But when we asked the onchologyst for a surgery, she replied: "Surgery for what?". So apparently surgery is not an option, maybe because there are more cells spread in different parts of the perithoneum. Thank you so much, Daniel.


   
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Daniel
(@daniel)
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Hi Anca,

I am sorry to hear your mom is not well after the last chemo combination. Regarding chemo options for ovarian cancer, you could ask Ergin, Alberto and other contributors on this website as they are also dealing with ovarian cancer. A chemosensitivity test may also show you other chemos that may be effective, which may be assigned to other types of cancer today. You can also read my response to Hectoria who is also fighting ovarian cancer https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/#comment-4637

From a diet point of view, given that you may not be able to follow restricted ketogenic diet, I think best is to focus on a diet that does not contain sugar, carbohydrates and avoid red meat due to glutamine. So a vegan-like diet would help.

I recommend to read carefully the comments on this post as you may get some ideas out of it  https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/

It is a pity that the oncologist answered like that. She should explain clearly and in a sensitive manner why surgery is not an option, and what could be the alternatives. Did she mentioned any clinical trial or immuno-therapy as an option?

Kind regards,
Daniel

 


   
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anca
 anca
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Hi Daniel,

My mother's oncologist didn't mention any clinical trial or immuno-therapy as an option. My mother is weaker and her immune system is so weak now that she has a boil like a big bump in the genital region. She also had very low number of platelets: 30,000 and it should be higher than 150,000 and they gave my mother blood plasma because she didn't have enough red cells, so she couldn't have the chemotherpay session today, she will have it on Wednesday. My mother is always tired and she needs to sleep. The family doctor told me that my mother should just take vitamin D and vitamin C, because those mushroomos Coriolus will be "killed" by the chemotherapy, now my mother doesn't want to take the Coriolus either, cause she thinks it is no use if she is under chemotherapy. What do you think about that?

Today in the hospital they gave my mother intravenous vitamin C. Maybe it will help. Since she started Carboplatin again in combination with Gemzar, she is feeling week, sleepy and her immune system is so low. I am thinking about doing this chemosensitivity test, but i don't know how long it takes for such tests to be done.

Today my mother met someone in the hospital, who told my her that she kept a strict vegetarian diet for 2 years and she was feeling weak and the colon cancer came back in the pancreas, and she eats everything now, she is having cancer for 11 years now and had chemotherapy all these years except 2 of them. Now my mother is convinced she can eat everything except sugar and she should eat meat and liver to have more platelets in the blood. I don't know how much the food really matters.

Thank you so much for your kind answer,

Anca

 

 


   
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anca
 anca
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Thank you so much for the answers, Ergin. I also read some of the comments from your page. I will search for Thalidomide and Tinzaparin in Romania. So sorry to hear about your mom, I hope she is better with all these treatments. My mom is worse after April unfortunately, because she had a recurrence in December. I will try hiperthermie, maybe it helps.

 


   
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anca
 anca
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Topic starter  

Hi Ergin,

I  want to try tinzaparin. Could you please tell me how should this be taken, by syringe or intravenous or by capsules?

Kind regards,

Anca

 


   
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Daniel
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Hi Anca,

Please check with your doctor. In general it should not be any problem, but for some people (and usually cancer patients are special) that may lead to internal bleeding if the dose is too high or if the blood condition is not suitable for using such medication. When fighting cancer we need to act but make sure you reduce the risks as much as you can related to any step.

Kind regards,

Daniel


   
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anca
 anca
(@anca)
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Hi Daniel,

Thank you for showing me the risks. I just wrote two pages of information from your articles and forum and will show it to the doctor. Maybe it will help some other patients.

Kind regards, Anca


   
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anca
 anca
(@anca)
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Topic starter  

Hi Ergin,

Thanks for your answer. My mom is hypothyroid as far as I know. She has a bigger problem now, she is under antibiotics for 7 days becuase she has a boil, like a bump in the genital area. Se took the antibiotics for 3 days but she wants to stop them even if she dies from septicemia because the pain in the stomach from the antibiotics is too much to endure, she feels she now has a wound in the stomach due to the antibiotics taken. I don't know how safe it is to stop the antibiotics after 3 days and how much is the risk of septicemia.

 


   
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Helga
(@helga)
Joined: 6 years ago
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Hi Anca,

I responded to you on the other thread but am just wondering: is the boil being helped by the antibiotic? Doctors tend to prescribe it for lack of a better treatment for mostly everything. I had/have a persistent bronchitis for 1-2 years but the doc still prescribed it for me anyway. The pharmacist told me nothing sour taken, not even vitamin C! They like to scare you, I think, makes them feel better about themselves (please, ignore this if your doctor is not like that). I said to the hell with this precaution and did take vitamin C and even citric acid (true, added some sodium bicarbonate) just not around the time I took the antibiotic. It is pathetic not to allow even vitamin C, considering how strongly acidic the stomach itself is. In the end vitamin C helped more than the bloody antibiotic, which I stopped after 6 days.

But if she feels the antibiotic is helping her somewhat, she/you could go back to the doctor and ask another antibiotic or a topical cream. In general, it would be good to strengthen her immune system with some natural substance. E.g. maitake or other mushrooms/extracts are great at it. Also, if she can take vitamin C, that would help a lot, too.

cheers,

Helga


   
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Emad
 Emad
(@emad)
Joined: 7 years ago
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Hi anca

I'm so sorry to hear about your challenges , my mother did have the same all the time , Carboplatin + Gemzar combination used to greatly hit the bone marrow , that's why we used to do blood transfusion for my mother in every cycle

 

in out case the oncologist did change to another chemo combination (5-FU + Endoxan + methotrexate) this combination didn't lowered the blood counts at all !

 

so there is chemotherapies that can do the job without doing damage to the bone marrow , also its better to add another solutions , DCA worked well for us and made the chemo work again , but DCA is just an example , there are a lot of patients who did take DCA without any positive effect at all , but don't bother with it , there is a lot of things to do and this great blog did documented a lot of treatments and options that have a chance to make things better , you should try always new things , and whenever you feel like nothing is working , don't stop , you should try more and more until you find something that do show positive effect , cancer is not invincible , just don't lose hope and fight hard and always focus and try to learn new things

 

I know how stressful you feel , just calm down and take a breath and think wisely , don't panic , you should believe that you can do it and make things better , focus and God will help you in your journey

 

wish the best for you anca

 

kind regards

Emad


   
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anca
 anca
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Joined: 6 years ago
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Topic starter  

Dear Helga,

Thank you for your advice, I had an exam and because my mom wanted me to take the best grade I didn't have time to read about treating her cancer. They say the psychological part is very important when people have cancer so we try to keep my mom happy and content. She took antibiotics for 5 days and she cured her boil, now she is feeling better, since she stopped chemotherapy 2 weeks ago, because it was not helping her at all. My mom is now carboplatin resistant. Since she is not taking platinum and Gemcitabine any more she is feeling much better without this toxic burn feeling in her mouth. 

Thanks to Daniel, now we took blood and sent it to Greece for a test to see what kind of chemotherapies might still work in my mother's case. If something still works, we will continue therapy when we have the results in one week. We also took blood test to see if my mom cand receive Vitamin C IV and we are waiting for the result. The CA-125 marker is very high now (more than 1,000), so her cancer is progressing and what we can do is hope for a miracle from God! You said you had bronchitis for 1-2 years, that's a long time! I cough often because my mom's cancer made me sad and lowered my immune system, I think I might have bronchitis and I hope it will not last 2 years.

Helga, how are you doing? I hope you are well.

Kind regards,

Anca

 


   
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anca
 anca
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Joined: 6 years ago
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Hi Emad and Ergin,

Thanks for your kind advice, it helped me so much. I told my mom there are other combinations and we just have to keep faith. My mom is very positive and strong, she is Sagittarius sign. She is stronger than all of us in the house :), we live in a house with my dad and me and my brother and his wife and daughter, we are like a traditional family living all together in a house. I guess this gives my mom strength and desire to fight the cancer. We have a garden with vegetables and fruits and also 6 hens, my mom eats organic eggs and black currants and raspberries fresh from the garden.

My mother is having a blood analysis in a clinic in Greece to see what kind of chemotherapies might still work for her. I hope there are other possibilities for her, although I read all these research articles on the Internet about platinum resistant ovarian cancer, which has a very poor prognosis and it's almost impossible to cure. What we can do is hope and pray to God that she will live more than expected.

I read your mothers are also fighting cancer, I hope they are doing well and the treatment is working. Do not forget the psyhcological part in fighting cancer, they say it is very important and a factor that has led to cancer so it is important to bring peace and happiness in their soul.

Kind regards,

Anca

 

 

   
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Helga
(@helga)
Joined: 6 years ago
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Dear Anca,

Are you still considering heparin for your mom? I was 'prescribed' a heparin lotion called Lioton (no prescription needed) and applied it to my belly (still undiagnosed but suspect I may have ovarian cancer) and also to my chest where my bronchitis originates from. It seems to me that this heparin ointment helps with both. Does your mom still have her ovaries? You could try to apply it, so you could also see how she generally reacts to heparin. It allegedly helps with communication between the cells. I am not sure they know the precise mechanism against cancer but it seems to be working.

Kinds regards,

Helga


   
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anca
 anca
(@anca)
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Topic starter  

Dear Helga,

I am not considering heparin anymore because of the risk o internal bleeding. But my mom has Lioton, she can use it any time. I am thinking about sstarting DCA,  after everything I read on this site, it might Help.

We are waiting for the blood results from Greece  and see what chemotherapies are good for my mom. This analysis costs 2500 Eur so it should cover mire substances that we don't want to test on my mom bere we know they help.

As far as I know, there is a blood test in my country that tells you if you have cancer somewhere in your body. It should be in your country too. It is pretty expensive here: 2000 Euro.  There is also the CA-125 blood test, which shows the risk for ovarian cancer. Did you do the CA-125 test? Then if the Ca--125 has a higher value  is higher that normal, there is the ultrasound available and then the CT-SCAN. I hope you are not having ovarian cancer, and wish you lots of health.

Kind regards,

Anca


   
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anca
 anca
(@anca)
Joined: 6 years ago
Posts: 17
Topic starter  

Dear Helga,

I am not considering heparin anymore because of the risk o internal bleeding. But my mom has Lioton, she can use it any time. I am thinking about sstarting DCA,  after everything I read on this site, it might Help.

We are waiting for the blood results from Greece  and see what chemotherapies are good for my mom. This analysis costs 2500 Eur so it should cover mire substances that we don't want to test on my mom bere we know they help.

As far as I know, there is a blood test in my country that tells you if you have cancer somewhere in your body. It should be in your country too. It is pretty expensive here: 2000 Euro.  There is also the CA-125 blood test, which shows the risk for ovarian cancer. Did you do the CA-125 test? Then if the Ca--125 has a higher value  is higher that normal, there is the ultrasound available and then the CT-SCAN. I hope you are not having ovarian cancer, and wish you lots of health.

Kind regards,

Anca


   
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anca
 anca
(@anca)
Joined: 6 years ago
Posts: 17
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Hi Ergin,

My mother started using Caelyx (Doxorubicin Lyposomal) three weeks ago and she is feeling weak, and tired all the time her CA-125 grew to 4000 and I  don't know what to do. She couldn't eat or drink. We did Vitamin C IV and Magnesium IV today and she felt better, she could drink water and eat fruits. Tomorrow we do ozone therapy, do you know if ozone therapy has some side effects, like spreading cancer? I am so sad, I try to stay optimistic, maybe next week we can do Caelyx chemotherapy again. Someone told me chemotherapy can kill my mom. Is this so dangerous? Without chemotherapy is worst I think...

Kind regards,

Anca


   
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anca
 anca
(@anca)
Joined: 6 years ago
Posts: 17
Topic starter  

Hi Daniel,

Do you think chemotherapy in my mother's case can do much worse or is it helping in a way? My mom is feeling tired and she has the CA-125 bigger it is 4000 now, and she barely eats ir drinks. Today we did Vitamin C IV an magnesium IV at Virgil and she felt better, she could drink and eat fruits. Tomorrow we do ozone therapy and I want to ask you if it has some side effects, like spreading cancer. I am so scared I could do worse. I am thinking to give another try to chemotherapy next week and have another seession of Caelyx, but I don't know how many sessions should be done to see some improvements? Virgil says chemotherapy can kill my mom, but I think it kept her alive these months... who knows. 

Kind regards,

Anca


   
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Daniel
(@daniel)
Admin
Joined: 7 years ago
Posts: 1156
 

Dear Anca, 

I am so sorry to hear about the developments while under the chemo treatments. There is a lot that I wrote on this website about how to try and improve chemo. You may want to share that with your doctor.

Beyond the info I shared here, due to ethical reasons I cannot advice if you should stop chemo or not. As I mentioned on the phone discussion we had, you and your mother have to think and feel what is best, decide, and know that you took the best decision you could based on what you now know.

Ergin's comments above and the offer to help with TM is very kind and you may want to consider that as well.

All the best to you mom, Anca!

Kind regards,
Daniel

 


   
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anca
 anca
(@anca)
Joined: 6 years ago
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Topic starter  

Hi Ergin,

Thank you very much for your offer, I speak totday with my mom and if she wants it I will write to you. I don't think we have checked ceruloplasmin levels from blood. What does it show?

Kind regards,

Anca


   
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anca
 anca
(@anca)
Joined: 6 years ago
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Topic starter  

Hi Daniel,

Thank you very much for your answer, we decided to try one more session with Caelys, because I read that it happens to some patients responding to treatment within the first 2 cycles of Caelyx to have a CA-125 higher than at the beginning,. My mother did 2 sessions and we will have one more to see if there is some result after the third session. If there isn't any improvement then I think we should stop Caelyx and the doctor also said that we need to try one more one more.

I read something about TM on your site, do you know people who had results with TM? Then I think I should consider Ergin's offer.

Kind regards,

Anca


   
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anca
 anca
(@anca)
Joined: 6 years ago
Posts: 17
Topic starter  

Dear Daniel.,

Thank you very much for your support. We are going at Virgil clinic and doing Vitamin C intravenous more times a week, we also did Magnesim IV and ozone therapy. My mom is weak and suffering much pain in the stomach from Caelyx. Your mother is very kind too and is sending messages to my mother and they also spoke on the phone. With such a support system I think my mother has a motivation to fight the disease. But at times she is losing hope and I give it back to her.

Kind regards,

Anca


   
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