Mebendazole --- Potential Treatment & Maintenance of Ovarian Cancer
Hi friends, just sharing the following here:
In this study, researchers performed a controlled evaluation of mebendazole's therapeutic efficacy in cell culture and in vivo models of ovarian cancer.
Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer
Available online 31 October 2020
• Mebendazole inhibits growth of ovarian cancer cell lines and high grade serous ovarian PDX tumors.
• Mebendazole inhibits tumor establishment in an orthotopic ovarian cancer model of maintenance therapy.
• Mebendazole's activity is related to p21 elevation and tubule destabilization, and complemented by mutant p53 reactivation.
This work demonstrates the therapeutic potential of repurposing mebendazole and supports clinical development of mebendazole for ovarian cancer therapy and maintenance.