Hi friends, just sharing the following here:
In this study, researchers performed a controlled evaluation of mebendazole's therapeutic efficacy in cell culture and in vivo models of ovarian cancer.
https://www.sciencedirect.com/science/article/abs/pii/S009082582034018X
Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer
Available online 31 October 2020
Highlights
• Mebendazole inhibits growth of ovarian cancer cell lines and high grade serous ovarian PDX tumors.
• Mebendazole inhibits tumor establishment in an orthotopic ovarian cancer model of maintenance therapy.
• Mebendazole's activity is related to p21 elevation and tubule destabilization, and complemented by mutant p53 reactivation.
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Conclusion
This work demonstrates the therapeutic potential of repurposing mebendazole and supports clinical development of mebendazole for ovarian cancer therapy and maintenance.
Thanks.
Kimster
