Patient with advanced gastrointestinal cancer (stage IV with supraclavicular lymph node involvement) on cycle 2 of CapOx. Integrative support was started 3–4 weeks before chemotherapy. Observed positive clinical changes include: supraclavicular lymph node was first measured at 5 cm on PET-CT scan, then palpated at approximately 2×3 cm before the first cycle, and is now felt even smaller and deeper on palpation before the second cycle; weight gain to 64.3 kg; resolution of anemia from the previous cycle; improved liver enzymes and reduced inflammation markers; good overall blood values before the current cycle; stable/low tumor markers (CEA 3.5 µg/L, CA19-9 6 U/mL); and good tolerance of treatment. Goal: maximize progression-free survival and quality of life through multi-pathway support focused on ferroptosis/apoptosis pulses, immune training, anti-inflammation (for albumin and red cell indices), and anti-metastatic effects.
Current CapOx Regime:
Oxaliplatin: 230 mg (≈130 mg/m²) IV every 21 days (infusion day with pre-medication: dexamethasone 8 mg + ondansetron 8 mg).
Capecitabine: oral tablets for 14 consecutive days per cycle.
Current status: Day 1 infusion completed; 14 days of tablets ongoing.
Complete Daily Supplement Stack (optimized for circadian rhythm, high bioavailability via liposomal forms and Piperine where beneficial, CapOx synergy, ferroptosis pulses, and immune training)
Morning (empty stomach, 30–60 min before food):
Baicalein Pro Liposomal – 200 mg
Berberine Pro Liposomal – 250 mg
Agaricus blazei Extract – 350 mg
Ivermectin – 12–18 mg (≈0.2 mg/kg, pulsed every 2–3 days under medical supervision; treatment ongoing in the Netherlands)
Modified Citrus Pectin (MCP) – 5 g (part of continuous daily dosing)
Midday / with meals:
Modified Citrus Pectin (MCP) – remaining 5 g (total daily 10 g, given continuously throughout the CapOx regime for sustained galectin-3 inhibition and anti-inflammatory support)
Evening (with or after dinner – recovery, anti-inflammatory, immune training & metabolic focus):
Maitake Liquid Extract – 1 serving (D-fraction β-glucans for trained immunity)
Turkey Tail (Trametes versicolor) Extract – therapeutic dose (for immune training and beta-glucan support)
Mesima (Phellinus linteus) Extract – therapeutic dose (for immune training and support, combined with all other mushrooms)
Boswellia Mega AKBA + PEA – therapeutic dose (strong anti-inflammatory)
Thymoquinone (high-potency, liposomal where available) + Black Cumin Seed Oil – 50–100 mg thymoquinone equivalent
Quercetin – 300–500 mg (synergistic flavonoïde/senolytische partner with myricetine)
Myricetin – 300–500 mg (liposomal or with Piperine where beneficial)
Apigenin – 200 mg (Pro Liposomal preferred)
EGCG / Curcumin C3 Pro Liposomal – standard therapeutic dose
Astragalus (with astragaloside IV) – 500 mg
Benfotiamine – 300–600 mg (fat-soluble B1 for metabolic and neuropathy support)
Bromelain – 500 mg (low dose, with platelet monitoring)
Ferroptosis Pulse Protocol (every 48 hours – multiple cell death layer):
Every 48 hours, the following compounds are emphasized/intensified as an extra ferroptosis and multiple cell death support window (Danshen, Shikonin, and Betulinic Acid are used only in this pulse layer):
Danshen – 500 mg
Shikonin + Betulinic Acid (liposomal with Piperine and astragaloside) – combined therapeutic dose
Myricetin – 300–500 mg
Baicalein Pro Liposomal – 200 mg
Thymoquinone – 50–100 mg
These compounds work together to increase selective ROS, lipid peroxidation, mitochondrial stress, and apoptosis/ferroptosis in cancer cells.
Near-Infrared (NIR) Hyperthermia Protocol (every 48 hours):
NIR hyperthermia session of 30 minutes, performed directly after the ferroptosis pulse compounds above.
Target: gentle elevation of core temperature to support ferroptosis via increased ROS, heat-shock protein response, and metabolic stress in cancer cells. Sessions are aligned every 48 hours with the ferroptosis pulse for synergistic effect and are monitored for safety and comfort.
Key Rationale & Synergies:
Ferroptosis & Apoptosis pulses (every 48h): Danshen, Shikonin + Betulinic Acid (liposomal with Piperine), Myricetin, Baicalein (p53 pathway), Thymoquinone (selective ROS), NIR hyperthermia (ROS boost).
Immune training & modulation: Maitake (D-fraction trained immunity), Turkey Tail, Mesima, Agaricus (NK/T-cell boost), combined mushroom approach for broad immune learning and support during CapOx.
Anti-inflammation (albumin & RDW/MCV support): Baicalein, berberine, Boswellia Mega AKBA + PEA, thymoquinone, bromelain, quercetin, MCP, and mushroom extracts.
Anti-metastatic & CEA stability: MCP (galectin-3 inhibition), Shikonin + Betulinic Acid, baicalein, and immune activation from the full mushroom combination.
Metabolic & mitochondrial support: Berberine (AMPK), Benfotiamine, ivermectin (pulsed; PAK1/WNT/mTOR modulation).
CapOx tolerance: Strong anti-inflammatory, antioxidant, and protective layers help maintain healthy cell function while increasing selective pressure on cancer cells. Liposomal forms and Piperine are used maximally to improve bioavailability.
Observed Positive Effects So Far:
Supraclavicular lymph node was first measured at 5 cm on PET-CT scan, then palpated at approximately 2×3 cm before the first cycle, and is now felt even smaller and deeper on palpation before the second cycle.
Weight gain to 64.3 kg.
Resolution of anemia from the previous cycle.
Improved liver enzymes and reduced inflammation markers.
Good overall blood values before the current cycle.
Stable/low tumor markers (CEA 3.5 µg/L, CA19-9 6 U/mL).
Good tolerance of CapOx with the supportive stack.
Monitoring:
Regular blood panels (CBC, liver/kidney function, albumin, RDW/MCV, CEA, CA19-9). Adjustments are made based on trends and clinical response.
Notes:
Supplements sourced for high purity; liposomal forms and Piperine used wherever beneficial for bioavailability.
Dosing started low and titrated with monitoring.
All interventions used under medical supervision with oncologist awareness.
This is a multi-pathway supportive approach designed to work alongside conventional treatment.
I will share further updates with new blood results or imaging. Constructive feedback from others with similar integrative protocols is welcome.
Also we give b12 high dose melt tablet and d3 k2 mk7
Patient with advanced gastrointestinal cancer (stage IV with supraclavicular lymph node involvement) on cycle 2 of CapOx. Integrative support was started 3–4 weeks before chemotherapy. Observed positive clinical changes include: supraclavicular lymph node was first measured at 5 cm on PET-CT scan, then palpated at approximately 2×3 cm before the first cycle, and is now felt even smaller and deeper on palpation before the second cycle; weight gain to 64.3 kg; resolution of anemia from the previous cycle; improved liver enzymes and reduced inflammation markers; good overall blood values before the current cycle; stable/low tumor markers (CEA 3.5 µg/L, CA19-9 6 U/mL); and good tolerance of treatment. Goal: maximize progression-free survival and quality of life through multi-pathway support focused on ferroptosis/apoptosis pulses, immune training, anti-inflammation (for albumin and red cell indices), and anti-metastatic effects.
Current CapOx Regime:
Oxaliplatin: 230 mg (≈130 mg/m²) IV every 21 days (infusion day with pre-medication: dexamethasone 8 mg + ondansetron 8 mg).
Capecitabine: oral tablets for 14 consecutive days per cycle.
Current status: Day 1 infusion completed; 14 days of tablets ongoing.
Complete Daily Supplement Stack (optimized for circadian rhythm, high bioavailability via liposomal forms and Piperine where beneficial, CapOx synergy, ferroptosis pulses, and immune training)
Morning (empty stomach, 30–60 min before food):
Baicalein Pro Liposomal – 200 mg
Berberine Pro Liposomal – 250 mg
Agaricus blazei Extract – 350 mg
Ivermectin – 12–18 mg (≈0.2 mg/kg, pulsed every 2–3 days under medical supervision; treatment ongoing in the Netherlands)
Modified Citrus Pectin (MCP) – 5 g (part of continuous daily dosing)
Midday / with meals:
Modified Citrus Pectin (MCP) – remaining 5 g (total daily 10 g, given continuously throughout the CapOx regime for sustained galectin-3 inhibition and anti-inflammatory support)
Evening (with or after dinner – recovery, anti-inflammatory, immune training & metabolic focus):
Maitake Liquid Extract – 1 serving (D-fraction β-glucans for trained immunity)
Turkey Tail (Trametes versicolor) Extract – therapeutic dose (for immune training and beta-glucan support)
Mesima (Phellinus linteus) Extract – therapeutic dose (for immune training and support, combined with all other mushrooms)
Boswellia Mega AKBA + PEA – therapeutic dose (strong anti-inflammatory)
Thymoquinone (high-potency, liposomal where available) + Black Cumin Seed Oil – 50–100 mg thymoquinone equivalent
Quercetin – 300–500 mg (synergistic flavonoïde/senolytische partner with myricetine)
Myricetin – 300–500 mg (liposomal or with Piperine where beneficial)
Apigenin – 200 mg (Pro Liposomal preferred)
EGCG / Curcumin C3 Pro Liposomal – standard therapeutic dose
Astragalus (with astragaloside IV) – 500 mg
Benfotiamine – 300–600 mg (fat-soluble B1 for metabolic and neuropathy support)
Bromelain – 500 mg (low dose, with platelet monitoring)
Ferroptosis Pulse Protocol (every 48 hours – multiple cell death layer):
Every 48 hours, the following compounds are emphasized/intensified as an extra ferroptosis and multiple cell death support window (Danshen, Shikonin, and Betulinic Acid are used only in this pulse layer):
Danshen – 500 mg
Shikonin + Betulinic Acid (liposomal with Piperine and astragaloside) – combined therapeutic dose
Myricetin – 300–500 mg
Baicalein Pro Liposomal – 200 mg
Thymoquinone – 50–100 mg
These compounds work together to increase selective ROS, lipid peroxidation, mitochondrial stress, and apoptosis/ferroptosis in cancer cells.
Near-Infrared (NIR) Hyperthermia Protocol (every 48 hours):
NIR hyperthermia session of 30 minutes, performed directly after the ferroptosis pulse compounds above.
Target: gentle elevation of core temperature to support ferroptosis via increased ROS, heat-shock protein response, and metabolic stress in cancer cells. Sessions are aligned every 48 hours with the ferroptosis pulse for synergistic effect and are monitored for safety and comfort.
Key Rationale & Synergies:
Ferroptosis & Apoptosis pulses (every 48h): Danshen, Shikonin + Betulinic Acid (liposomal with Piperine), Myricetin, Baicalein (p53 pathway), Thymoquinone (selective ROS), NIR hyperthermia (ROS boost).
Immune training & modulation: Maitake (D-fraction trained immunity), Turkey Tail, Mesima, Agaricus (NK/T-cell boost), combined mushroom approach for broad immune learning and support during CapOx.
Anti-inflammation (albumin & RDW/MCV support): Baicalein, berberine, Boswellia Mega AKBA + PEA, thymoquinone, bromelain, quercetin, MCP, and mushroom extracts.
Anti-metastatic & CEA stability: MCP (galectin-3 inhibition), Shikonin + Betulinic Acid, baicalein, and immune activation from the full mushroom combination.
Metabolic & mitochondrial support: Berberine (AMPK), Benfotiamine, ivermectin (pulsed; PAK1/WNT/mTOR modulation).
CapOx tolerance: Strong anti-inflammatory, antioxidant, and protective layers help maintain healthy cell function while increasing selective pressure on cancer cells. Liposomal forms and Piperine are used maximally to improve bioavailability.
Observed Positive Effects So Far:
Supraclavicular lymph node was first measured at 5 cm on PET-CT scan, then palpated at approximately 2×3 cm before the first cycle, and is now felt even smaller and deeper on palpation before the second cycle.
Weight gain to 64.3 kg.
Resolution of anemia from the previous cycle.
Improved liver enzymes and reduced inflammation markers.
Good overall blood values before the current cycle.
Stable/low tumor markers (CEA 3.5 µg/L, CA19-9 6 U/mL).
Good tolerance of CapOx with the supportive stack.
Monitoring:
Regular blood panels (CBC, liver/kidney function, albumin, RDW/MCV, CEA, CA19-9). Adjustments are made based on trends and clinical response.
Notes:
Supplements sourced for high purity; liposomal forms and Piperine used wherever beneficial for bioavailability.
Dosing started low and titrated with monitoring.
All interventions used under medical supervision with oncologist awareness.
This is a multi-pathway supportive approach designed to work alongside conventional treatment.
I will share further updates with new blood results or imaging. Constructive feedback from others with similar integrative protocols is welcome.
We have leaves berberine from the stack because with the low bloodpolasma concentration we can reach it has paradoxely contra effect and can simulate inhibition of chemo sensibility and can stimulate tumor growth in the low reachable concentration s.
@stanley1, good to hear all interventions are done in coordination with the oncologist.
Regarding the high-dose B12 supplementation, is the patient B12-deficient?
This study found that colon cancer patients with very high B12 levels survived a median of around five years, compared with nearly eleven years for those with normal levels.
If your aim is ferroptosis, some of the supplements you list may work against it (Nrf2 activators).
Yes light Annemie, bit from last blood results that was already slightly better so we halved b12 supplements tion for now to next bloodlevels to adapt to. Yes we now about the nrf2 and try to make a balance in it with on and of and extra ferroptose boosts. The stack as i described is the big line in it but the supplements we try to modulate and adapt to each others interactions and bloodtests.
Wich supplements you think have the strongest nrf2 activation i now that to much nrf2 can have an resistant tumor effect because of sirt1 dysfunction and the anti oxidant workings wich can reduce ferroptose.
Correct me if im wrong and what is your view. Thanks for the reply
Patiënt is my wife and had gastric cancer 2,5 years before they dit a gastrectomie by then so b12 and more supplements we have to look wich have good absorption rate or liposomaal, Piperine and bromelaïne also give better absorption rates and blood plasma levels for much things and form of melt tablet we use for b12 supplementation
Wich supplements you think have the strongest nrf2 activation i now that to much nrf2 can have an resistant tumor effect because of sirt1 dysfunction and the anti oxidant workings wich can reduce ferroptose.
Correct me if im wrong and what is your view. Thanks for the reply
Sulforaphane and Resveratrol in particular. Some weaker Nrf2 activators: Curcumin, EGCG, Quercetin, Cinnamon, Baicalein, Andrographis.
Apigenin, Luteolin, Chrysin, and Brucea Javanica are strong Nrf2 inhibitors: https://synergiesforcancertreatments.blogspot.com/2026/07/cancers-weak-spot.html (listed near the end of the page)
Sulforafan we use onle in restweek after capox 4 days boost and resevatrol 2days in restweek only the others are mostly 4 days of 2 days ony continu and some everyday because there are also other synergetic anti cancer effects especially with capox regime, who can possibly outweigh the negatives of the slightlylight activation of it. I think as long its in the combination smart combined its netto more nrf2 reducing than promoting, with the total stack and ferroptose boost we keep the most nrf2 activaties off. We keep monitoring it.
Apigenin, Luteolin, Chrysin, and Brucea Javanica also for restweek to give the body extra recovery and for the other possible anti-cancer effect
