Doxy-Myr --- Chemically Modified Doxycycline
Hi friends, just came across this information so just adding here:
Metastasis prevention is a new weapon in the war on cancer
by University of Salford
SEPTEMBER 17, 2020
Unfortunately, many cancer patients ultimately undergo tumor recurrence, resulting in distant metastasis (cancer spread).
As a result, more than 90% of these patients that undergo treatment failure, die from metastatic disease. Therefore, the discovery of inhibitors of metastasis could turn cancer into a chronic treatable disease and remove the fear from a cancer diagnosis.
In order to fill this knowledge gap and meet clinical needs, researchers at the University of Salford have identified that the Achilles' heel of metastasis is ATP-depletion, which can be achieved by simply removing the cancer cell's ability to make new energy.
Professor Michael Lisanti and Professor Federica Sotgia, who both work in Translational Medicine at The University of Salford, have designed and tested new inhibitors of cancer metastasis that are based on an existing FDA-approved antibiotic, namely Doxycycline, first approved in 1967.
They have now chemically modified Doxycycline, making it five times more potent for the targeting of metastatic cancer cells. Fortunately, this modification also renders Doxycycline ineffective as an antibiotic, effectively removing the risk for the development of antibiotic resistant bacteria and infections.
In addition, they show that this new drug, which is named Doxy-Myr, to reflect that addition of a fatty acid, is also non-toxic in pre-clinical studies.
Professor Lisanti said: "While this new family of drugs must now undergo clinical trials the work directly shows proof of concept that it is feasible to successfully design drugs that can prevent metastasis, by targeting the process of cellular energy production. Hence, cutting off the fuel supply, prevents metastasis. This breakthrough could ultimately change clinical practice, by adding metastasis prevention, as a new, more effective, weapon in the war on cancer."
ORIGINAL RESEARCH ARTICLE
15 September 2020