TET2 (a cancer suppressor) is a somewhat common mutation in cancer. It has been suggested that Vitamin C / Vitamin A might upregulate it in those with low expression levels and have an anti-cancer effect (see second pdf pages 15, 23-28), 20% in MDS {MDS is described as a cancer of methylation in second pdf}, 40% in CML, 17% in AML, CLL 5.7%, 12% non-Hodgkin, 9% melanoma, 1-4% of other solid tumors.
This is somewhat remarkable that cancer might have a treatable/preventable route through Vitamin C etc.. I encourage others on forum to probe this further.
https://www.mycancergenome.org/content/gene/tet2/
https://www.mds-foundation.org/wp-content/uploads/2017/03/Miami-Transcription-Part-1.pdf
Thank you
Your welcome.
Genomic thinking could be a powerful addition to our discussions on forum. Think how one might be able to magnify the range of treatment by simply genome sequencing a normal cell and a tumor cell. The below url describes the mutational landscape of tumors. Perhaps even more powerful would be to think in terms of the totality of the mutations involved any of the thousands and thousands of mutation typically present in tumors could be a serious weakness. E.g., I posted recently about trying an elemental diet of essential amino acids. Genome sequencing tumor cells would provide knowledge in advance about the expected response. Knowing the MCT-1 status would also be helpful to know for 3-BP response. This is an extremely powerful approach to choosing treatments. The forum should think contemplate this idea.
