synergistic effects of artesunate and ursolic acid on lipid reduction
Lipomics analysis revealed the change of many fatty acids in the serum of the drug treatment groups. The down-regulated fatty acids were long chain fatty acids, such as undecanoic acid, tetracosanoic acid, linoleic acid, alpha-linolenic acid, arachidonic acid, oleic acid, and palmitic acid. However, short chain fatty acids, such as acetic acid and butyric acid were upregulated in the plasma, compared with the model group. We speculated that artesunate and ursolic acid could promote the decomposition of long chain fatty acids into short chain small molecule fatty acids. Cholesterol is metabolized by the enzyme CYP7A1 to produce cholic acid . The content of cholic acid was upregulated compared with the model group, which indicated that artesunate and ursolic acid could promote the conversion of cholesterol to cholic acid.