Garlic - possible treatment  

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Aspek
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14/12/2019 6:28 pm  
Hello all,
 
I wanted to share some of my data collecting about this quite interesting plant. 
 
As an introduction, studies about decreased chance to get cancer:
 
Onion and Garlic Intake and Breast Cancer, a Case-Control Study in Puerto Rico  
Raw garlic consumption and lung cancer in a Chinese population
 
Also, it is garlic and extract from garlic show different immunomodulatory effects:
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
 
Regarding cancer, garlic seems to fight on multiple fronts:
 
Allicin (from garlic) induces caspase-mediated apoptosis in cancer  cells.  
Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 
Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy
 
Most interesting information regarding cancer is this publication from December 2018 where IP injections of RGE (raw garlic extract) 24 after the injection of EL4(lymphoma cells) completely blocked cancer cells without harm to the mouse. Also, in the test they showed that RGE in vitro completely inhibited J82, Hela, 5637, S18, and K562 while 60% of PME (polymorf human nucleus) remained active. This would explain why there was no adverse affect on the mouses. On the side note, mouses that were simply eating same amount of garlic, developed ascites as the control group.
 
Link to the article is here:
A novel therapeutic anticancer property of raw garlic extract via injection but not ingestion
 
On the bad side, there was a study from 60 about allicine wher they concluded that allicine preincubated with sarcoma cells injected together resulted in destruction of cancer cells, but subsequent injection did not. 
On the good side, they tested only extracts and in the article from 2018 it is hypothesized that it is not allicine but some other organic molecules that cause curing effect. Also, in this study RGE was injected 24 later and that could be considered as an already established tumor.
 
On the further notice in 2015  Azizkhani, Behnam patented garlic injections/IV as a treatment to herpes. With an concentration of 0.065ml/kg he treated himself and 89 patients to stop the herpes infection. Also, there is mention that various animals (rabbits, cows, sheeps and goats) were tested with 0.1 ml/kg with no side effects even with the pregnant animals. At the beginning, he performed the test on himself with direct injection, but because of the pain he tried it IV and concluded that this was the easiest way of application.
 
Link:
HERPES TREATMENT
 
All this is very fascinating in my opinion and if we accept this herpes patent as a human test and test that prof. Zheng Cui made with mices there is a chance IV garlic can be a viable treatment or at least something that could affect cancer in a beneficial outcome for us. 
 
 
 
 
Warning:
According to the stoputiforever.com the lowest toxicity dose associated with garlic was 400mg/kg.
Also garlic affect the coagulation, so even with just eating garlic if you take Warfarin there is a danger of combined effect and consequentially danger of internal bleeding. 
 
I would be really happy to hear comments from you and a discussion how to possibly apply this information to cancer treatments. 
 
Anyway it seems to me that with the garlic we cannot make a mistake.
 
This topic was modified 1 month ago 2 times by Aspek

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johan
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14/12/2019 9:40 pm  

Thanks, Aspek! Btw, to activate allicin in garlic chop or crush and let sit for 10 to 15 minutes.


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Aspek
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14/12/2019 10:15 pm  

@johan

Exactly :). And in the study they stored RGE at -80 deg. celsius to prevent degradation.

But, thank, you Johan. I am following this forum for couple of weeks now and I could really learn from your comments. 

I wanted to share this because I found really fascinating that one plant was so selective and efficient vs. cancer cells (in this study they tested around 20 different vegetables/plants). And a lot of publications  are  insinuating that garlic is/could be preventive against cancer of mouth, throat, eschopagus and stomach - exactly where the body gets in contact with raw garlic.

 

One comment more from you please 🙂

Do you think that mixing garlic juice with DMSO could deliver the molecules deeper into skin and like this possibly  influence/treat skin cancer? 


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johan
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14/12/2019 10:45 pm  

It would indeed improve absorption. As you know the compound allicin has serious stability issues due to rapid degradation. Hence increasing absorption makes sense.

Also, therapeutic amounts of stable allicin in the bloodstream can be obtained by taking a supplement called Allimed. 

Applying curcumin topically, in addition to a garlic mixture could provide addition anticancer benefits.

 


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Nuc
 Nuc
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15/12/2019 5:19 pm  

Hello,

New to the forum.  My wife has stage 4 colon cancer and I read with great interest Dr. Cui's study.

I purchased the equipment necessary to make the RGE, with the plan to subcutaneously inject the sterile RGE.  The problem I've run into is that the injection is painful during and for a couple minutes.  No edema, redness, etc... afterwards.  I've attempted to reduce the burning sensation by pH balancing the RGE, as it is quite acidic.  I even purchased the 3k dalton micro tube filters, hoping that the compound that causes the temporary burning sensation would be filtered out, but no luck.  I've now settled upon cryogenic cooling of the area where I will do the injection.  I hope that alleviates the temp. discomfort.

Any other ideas?


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johan
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15/12/2019 6:48 pm  

Hi Nuc, maybe you could try contacting Dr Cui: https://www.researchgate.net/profile/Zheng_Cui6

I hope someone on the forum will be able to provide ideas to help reduce the pain. 

Best of luck

 


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johan
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15/12/2019 7:11 pm  

Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2.

https://www.ncbi.nlm.nih.gov/pubmed/20924970

100% Allicin: https://www.allimax.us/Allimed-Capsules-60-Count


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Aspek
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15/12/2019 7:21 pm  

@doctrlevine

Hello,

In the article about herpes treatment (there is also a link above- patent from Azizkhani) he mentioned hidrocortisone as an anti inflamatory addition and prevention from possible shock. He  tested injections and IV solution for that. This paragraf starts with "injection considerations" and there he explained in detail what was the most comfortable for the patients. 

In that article he also states that oral or skin application did not have an effect, but seems to me that trying with DMSO to pass the skin barrier could be viable possibility. 

To increase to required concentration i would use all three options: IV, DMSO and subcutaneously.

One more thing: Allicine is very potent. It kills cancer cells, microbe cells and even healthy cells. Study from sixties i mentioned above stated that sintetic alicine injected into mices eventually caused necrosis. This article from 2004 (ref.) states that scientist from Izrael made smart bomb from allicine to treat cancer. What i mean with that, IV diluted with NaCl solution is probably safest way to deliver RGE. And then couple of questions remain:

1. Is really allicine exclusively - delivering this effect? - Allicine dissolves after 1 hour. They incubated the cells for 24 hours at 37 deg. celsius and all cancer cells were dead. I really don't know is this 1 hour of existing allicine was responsible of that or the components that form after allicine degradation. Maybe prolonged dosing is possible.

2.  Question of dosing - if average person has 5 l of blood and critical concentration was 1/200 to eradicate all cancer cells, that would require 25 ml of RGE. This is very difficult to achieve with IV. Even 1/300 concentracion that destroyed 50% of cells is around 16 ml and that is also a lot. Around 5 ml (0.065ml/kg) for a 80 kg person was tested as herpes treatment and we can consider that safe. Everything else was tested on animals.

3. Matter of duration of treatment - mice were treated for 21 day with a high concentration. Possibly, lower concentration in a longer period would give the same results.

 

My suggestion is to try different version of application at the same time to lower the discomfort to the patient. So IV, IP (pertional), subcutaneously, DMSO, IM(muscular), holding garlic in the mouth to get it this way in blood and even some kind of suppository. Combining this to get as less discomfort as possible and concentration as high as possible.

 

In the end, this herpes treatment was the only test with garlic injection i found they made with humans so this is my reference point. 

 

P.s. They even cured trees with garlic. (ref.)

 


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Nuc
 Nuc
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15/12/2019 9:44 pm  

@johan

Thanks, I've tried to contact him at Wakeforest, he is no longer there.  Also through the initial research study in Nature and through a friend of his who wrote an article about his findings and how they have not been picked up by any national news media org.  As far as I can tell, he is now working for a biotech firm that is pursuing his earlier work with transplanting Granulocytes into cancer pts.

 

Adam


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Nuc
 Nuc
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15/12/2019 9:47 pm  

@johan

If Allicin is the functional ingredient in Garlic that worked so well for Dr. Cui (study only showed that it was something smaller the 3k Daltons), he showed that taken orally, there was no effect.  Needs to bypass the digestive system as the cancer killing properties are negated by the digestive system.

 

Adam


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johan
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15/12/2019 10:03 pm  

@doctrlevine

Adam, he seems to have used a plain raw garlic extract for oral consumption,  from what I read I do believe a supplement such as ALLIMED could be far more effective.

https://www.allimax.us/Allimed-Products

(btw, I have absolutely no affiliation with this company)


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johan
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15/12/2019 10:34 pm  
Posted by: @doctrlevine

@johan

If Allicin is the functional ingredient in Garlic that worked so well for Dr. Cui (study only showed that it was something smaller the 3k Daltons), he showed that taken orally, there was no effect.  Needs to bypass the digestive system as the cancer killing properties are negated by the digestive system.

 

Adam

According to the information available to date, allicin appears to be the anticancer compound in colon cancer.

"Furthermore, allicin is also responsible for the antiproliferative effect of garlic derivatives on human colon cancer cells." Ref


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Nuc
 Nuc
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15/12/2019 10:43 pm  

@johan

In Dr. Cui's study, he gave the mice 100mg wet weight RGE.  The typical mouse weighs ~20g, so he was feeding them 1/200th of their weight in RGE/day, with no positive effects.  My wife, at 48kg would need to eat 240g of RGE to equal that amount.  Garlic contains ~4mg of allicin per gram of crushed garlic. So at 1:9, garlic to distilled water, that would be 24g of pure allicin.  Allimax pro contains 450mg per capsule, so that would be 53 capsules per day (more if your body weight is greater), with no better outcome then the control mice, death in 21 days.  If allicin is the ingredient in RGE that is what worked for Dr. Cui, we don't know that it is, the digestive system definitely renders, even extremely large ingested amounts, useless.

The molecular weight of allicin is 162 Daltons so it would have passed through the 3k Dalton filter, so maybe it is the active ingredient.

It's not a problem if treating the human takes longer then 14 days.  I was ok with that and was going to be SC injecting, as many mls. in different spots, that I could.  I was hoping at least 5 mls/day.

Still thinking that icepacking the skin previous to treatment may be the only way to decrease the temp. burning feeling.

@Aspek, I'll need to check out the study you mentioned and read your post a couple more times 🙂

One thing that Dr. Cui noted and graphed was the selectivity of the RGE to kill many more cancer, then normal cells.  But yes, there was some normal cells being affected.  Better then chemo or radition 🙂

 

Adam  


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johan
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16/12/2019 6:17 pm  

@doctrlevine

I hope the icepacking the skin helps, Adam. Please do keep us updated, I sincerely hope this will work for your wife.

Best,

Johan

PS. I found the following related to the pain/burning: 

Oleic acid inhibition of TRPV1

https://www.cell.com/fulltext/S0960-9822(05)00391-X

https://www.nature.com/articles/ncomms13092


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Nuc
 Nuc
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16/12/2019 7:26 pm  

@johan

Thanks a lot for the info. on Oleic Acid.  I ordered some, will sterilize and try it out 🙂

 

Adam


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johan
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16/12/2019 7:38 pm  

good luck!


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Nuc
 Nuc
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17/12/2019 8:23 pm  

First update for the group.

Success so far.

I had made up a batch of pH neutral RGE, that I had added 1/2 peeled apple.  I read a few places that people counteract their garlic breath "smell" by eating an apple, so I thought I'd give it a try.  Not sure if the apples enzyme's, may render the allicin ineffective.  Most important was that it would be bearable to inject.  We did the ice compress, 5-10 mins, until numb.  Quickly injected 1 ml. of the neutral RGE with apple, hardly any discomfort at all.  Prior to injecting, it smelled like normal RGE and still tasted strongly of garlic, though with a slight sweet taste from the apple.  

Tomorrow, I will get some fresh garlic, make a new batch of neutral RGE, though with no apple.  And see if the icepack is still as effective with pain control.  Questioned 10 min. after injection, no discomfort, redness, swelling etc...

Oleic acid is on its way also.

Adam


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GgE
 GgE
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18/12/2019 4:22 am  

Hello everybody. I read in Dr. Cui's article that “Other vegetables and fruits, such as cauliflower, red grape, guava, and strawberry also showed similar anticancer properties, but, unlike RGE, the extents of their activities varied from cancer cell lines to lines.” In other words, garlic worked on all cancers but each one of these other plant products worked only on some cancers.

Is there info on which ones of them worked on what type of cancer and under what conditions? This info might solve the problems encountered when injecting RGE because their juices seem to be much less irritating.

It might also solve another problem posed by garlic: garlic is very high in phytoestrogens and injecting its extract into a hormone-responsive tumor could fuel its growth instead. This info could be very helpful to millions of people given that hormone responsive tumors are among the most common in breast and prostate cancer

Is there any recent clues about how to contact him or some associates familiar with his garlic study and ask them?


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Aspek
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18/12/2019 8:51 am  

@gge

there is info about Helo, J82 and 5637 cancer cell lines.

The cancer cells were plated at
15% conuence and grew for 24 h at 37 °C before the
juices were added to a 1/200 dilution factor of their
respective wet weights (5 mg/1 ml). The pH values of the
nal solutions were unaffected as the volumes of the
added extracts were relatively small and the culture
medium color indicator of pH remained unchanged till
the end of cell culture. The cells were co-cultured for
another 24 h at 37 °C before the viable cells in each well
were analyzed with CCK-8 kit.
 
For these specific cell lines the results were showed in picture 3.
 
 
Neutralizing with apple was really nice idea. But maybe its possible to use something else from the fig. 3 what has stronger general anticancer properties. (redgrape, guava or strawberry for example)

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Aspek
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18/12/2019 9:13 am  

Another interesting article about vegetables in general (in vitro):

Link


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JulienAch
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18/12/2019 3:20 pm  

An interesting study about food in general with some human datas, mostly epidemiological and centered on prevention but I'm convinced that combining a maximum of these food product can help even with a active cancer.

Anyway, its the kind of information everybody should be aware of...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184418/


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asafsh
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28/12/2019 10:26 pm  
Posted by: @johan

Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2.

https://www.ncbi.nlm.nih.gov/pubmed/20924970

100% Allicin: https://www.allimax.us/Allimed-Capsules-60-Count

Hi Johan

There was a study on allicin done in 1959 with no considerable prove of its tumor inhibition property. Kindly find related article below:

https://cancerres.aacrjournals.org/content/20/4/431

From what i could understand from Mr Zheng Cui's letter is that

"The reductionist view also led to many studies of the individual compounds isolated from garlic for their anticancer properties. In most animal studies, when garlic or the purified garlic compounds were given via ingestion, the direct anticancer effects were weak at best"

and

"This activity was contributable to the multiple garlic compounds that were partially heat-sensitive, organic-soluble and smaller than 3000 Dalton."

i am not physician (i am cancer patient's relative) and may only guess that the anticancer properties of RGA is still unknown and is made of multiple re-actions of molecules it is constituted from. 


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asafsh
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28/12/2019 10:30 pm  
Posted by: @doctrlevine

First update for the group.

Success so far.

I had made up a batch of pH neutral RGE, that I had added 1/2 peeled apple.  I read a few places that people counteract their garlic breath "smell" by eating an apple, so I thought I'd give it a try.  Not sure if the apples enzyme's, may render the allicin ineffective.  Most important was that it would be bearable to inject.  We did the ice compress, 5-10 mins, until numb.  Quickly injected 1 ml. of the neutral RGE with apple, hardly any discomfort at all.  Prior to injecting, it smelled like normal RGE and still tasted strongly of garlic, though with a slight sweet taste from the apple.  

Tomorrow, I will get some fresh garlic, make a new batch of neutral RGE, though with no apple.  And see if the icepack is still as effective with pain control.  Questioned 10 min. after injection, no discomfort, redness, swelling etc...

Oleic acid is on its way also.

Adam

Dear DoctrLevine  I am also trying to find a way to convince local treatment physician to try this method for my cousin. She is diagnosed with mesenchymal chondrosarcoma and tumor advanced towards brain. Appreciate if you can share your observations and results here. My best wishes.


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Nuc
 Nuc
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28/12/2019 11:06 pm  

Aspek, I used apple only because a study showed it, lettuce and mint, were most effective at combatting garlic breath, as they counteracted the sulfides.  Not sure that they are the cancer killing compounds or not.  If it's allicin, then no problem.

 

Update 2.

RGE, pH balanced injected into  cooled skin, still to painful to inject full ml.

Oleic acid has arrived and will make pH neutral RGE with it, and try again, with ice, for effect.  It'll have to wait till New year as I'm out of town at the moment.  If not tolerable, will go back to apple addition to RGE, also will experiment with blended, strained,centrifuged, lettuce, added to the RGE.

Once I find what's best, will continue checking tumor markers each week, to look for effect.


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asafsh
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29/12/2019 12:13 am  

@doctrlevine

Thank you very much for update. 

what do you think about feasibility of using local anesthetic application (let say used by dentists) before RGE injection? It might give longer time window for more RGE injection volume.

 


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asafsh
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29/12/2019 2:13 pm  

"Freezing improved the antioxidant activity of broccoli and garlic, but had detrimental effects for cauliflower and onion." link


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