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Anti-cancer Chinese Herbal Formula

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Kimster
(@kimster)
Joined: 4 years ago
Posts: 115
Topic starter  

Hi friends, just sharing the following here:

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303939/

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model

Published online 2018 Dec 22.

Abstract

Background

The incidence and mortality of cancer metastasis is high worldwide.

Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments.

However, most of these herbal formulae/products lack of evidence-based efficacy.

Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely:

Andrographis paniculata,

Acanthopanax senticosus,

Camellia sinensis,

and

Hedyotis diffusa

were eventually selected to form an innovative herbal formula.

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Results

Our results showed that the breast tumor weight as well as lung and liver metastasis in mice could be reduced after herbal formula treatment for 4 weeks.

The breast tumor-induced osteolysis in mice was restored by herbal formula treatment, in which the bone volume in treated mice tibia was comparable to that in the non-tumor bearing normal mice.

The IL-12 level was augmented and the survival of mice with metastatic breast tumors was prolonged after treatment.

Furthermore, combination of herbal formula with chemotherapeutic agent doxorubicin resulted in better anti-tumor efficacy and increased life span in tumor-bearing mice, when compared with doxorubicin alone treatment.

 

Conclusions

In summary, our innovative Chinese herbal formula was demonstrated to possess anti-tumor, anti-metastatic and bone-protective activities in metastatic breast tumor-bearing mice.

The preclinical data generated in this study would lead to the development of evidence-based supplement as adjuvant therapy for metastatic breast cancer.

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We aimed to apply innovative concepts of evidence-based, multi-targeted and quality-assured for developing a herbal formula targeting on metastatic breast cancer.

Our findings provided scientific evidences on this hypothetically created herbal formula in breast tumor-bearing mice.

We are ready to go for a clinical trial using this herbal formula and the promising outcome from the trial may provide alternative treatment option for metastatic breast cancer patients in the future.

 

 

Thanks.

Kimster


   
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Kimster
(@kimster)
Joined: 4 years ago
Posts: 115
Topic starter  

Hi friends, just would like to add further information from the same article:

 

https://cmjournal.biomedcentral.com/articles/10.1186/s13020-018-0222-9

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In the past decade, our research team has carried out a series of investigations on the anti-tumor activities of various Chinese medicinal herbs and their isolated compounds.

Among these herbs, 

Andrographis paniculata (AP, 穿心蓮), 

Acanthopanax senticosus (AS, 刺五加), 

Camellia sinensis (CS, 綠茶),

and 

Hedyotis diffusa (HD, 白花蛇舌草)

were shown to have promising anti-cancer-related bioactivities.

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The optimal dosages of each herb have been validated in the corresponding in vivo experiments mentioned above.

Based on these results, an innovative herbal formula of these four constituent herbs with particular reference to the properties was formed using their corresponding optimal dosages, hence, the ratio of each herb in the formula was AP:AS:CS:HD = 1.7:1:1:8.

This formula was designed for cancer patients as it was expected to augment and to relieve the discomfort from the conventional cancer treatment as well as prevent recurrence.

The present study aimed at evaluating the efficacies of the herbal formula in our breast tumor-bearing mice model.

Promising results showed the anti-metastatic effects of the formula.

Furthermore, the adjuvant activities of the formula to chemotherapeutic agent doxorubicin in metastatic breast cancer mice were illustrated for the first time.

 

 

Thanks.

Kimster


   
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Kimster
(@kimster)
Joined: 4 years ago
Posts: 115
Topic starter  

Hi friends, just adding the following - recent article related to Hedyotis diffusa (HD, 白花蛇舌草):

 

https://www.sciencedirect.com/science/article/pii/S0753332220309288

Antitumor potential of Hedyotis diffusa Willd: A systematic review of bioactive constituents and underlying molecular mechanisms

Available online: 12 September 2020

Highlights

• The antitumor active components of Hedyotis diffusa Willd were screened out.

Multiple components developed antitumor activities via multi-target and multi-pathway.

• We provided the latest evidence for molecular mechanisms of antitumor activities.

• We provide a reference for the further development and utilization of H. diffusa.

• The review enumerated the clinical application and potentially toxic ingredients.

 

Abstract

Cancer is a major cause of death in the world.

Chemotherapy can extend the life of cancer patients to some extent, but the quality of life is reduced. Therefore, the quest for more efficient and less toxic medication strategies is still at the forefront of current research.

Hedyotis diffusa Willd (HDW), a Chinese herb medicine, has received great attention in the past two decades and has been well documented in clinics for antitumor activity in a variety of human cancers.

This review discussed a total of 58 different kinds of active antitumor components isolated from HDW, including iridoids, flavonoids, flavonol glycosides, anthraquinones, phenolic acids, and their derivatives, sterols, and volatile oils.

Their antitumor activities include

inhibition of tumor cell proliferation,

induction of tumor cell apoptosis and tumor angiogenesis,

regulation of the host immune response,

anti-inflammatory and antioxidant,

and

protective autophagy.

Besides, we provide up-to-date and systematic evidence for HDW antitumor activities and the possible underlying molecular mechanisms and reference for further development of novel drugs and dosage formulation in control of human cancers.

 

 

Thanks.

Kimster


   
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Kimster
(@kimster)
Joined: 4 years ago
Posts: 115
Topic starter  
Posted by: @kimster

Hi friends, just adding the following - recent article related to Hedyotis diffusa (HD, 白花蛇舌草):

Hi friends, just adding the following for this Chinese medicinal herb:

 

https://www.mskcc.org/cancer-care/integrative-medicine/herbs/oldenlandia-diffusa

Scientific Name

Oldenlandia diffusa, Hedyotis diffusa

 

Common Names

  • Bai Hua She She Cao (白花蛇舌草)
  • Herba Oldenlandiae
  • Snake-Needle Grass

 

 

https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hedyotis-diffusa

Hedyotis diffusa

An herb used in traditional Chinese medicine to treat certain medical problems.

It has been used to boost the immune system and may have anticancer effects.

 

 

Thanks.

Kimster


   
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