Resveratrol is a glycolisis inhibitor (pyruvate dehydrogenase (PDH) inhibitor)  


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27/01/2019 1:26 am  

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells

This is an article published in one of the best scientific journal, Nature,. Some relevant quotes:

"Resveratrol modifies the lipidomic profile, increases oxidative capacities and decreases glycolysis, in association with a decreased pentose phosphate activity and an increased ATP production. Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity. Calcium chelation, as well as the blockade of the mitochondrial calcium uniport, prevents the resveratrol-induced augmentation in oxidative capacities and the increased PDH activity suggesting that calcium might play a role in the metabolic shift."

Our study provides evidence that a low dose of resveratrol, close to the amount found in the serum of resveratrol-treated human patients, is able to modify cancer cell metabolism in colon cancer cells, with an alteration of lipidomic profile and a reversion of the Warburg effect. Resveratrol clearly increases the oxidative capacities of cancer cells and decreases the glycolysis. We propose that the PDH complex is a novel target for resveratrol through a Ca2+/AMPK signaling pathway.

This topic was modified 5 months ago by Daniel