Resveratrol is a glycolisis inhibitor (pyruvate dehydrogenase (PDH) activator)  

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Daniel
(@daniel)
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Joined: 4 years ago
Posts: 505
27/01/2019 1:26 am  

Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells https://www.nature.com/articles/s41598-017-07006-0

This is an article published in one of the best scientific journal, Nature,. Some relevant quotes:

"Resveratrol modifies the lipidomic profile, increases oxidative capacities and decreases glycolysis, in association with a decreased pentose phosphate activity and an increased ATP production. Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity. Calcium chelation, as well as the blockade of the mitochondrial calcium uniport, prevents the resveratrol-induced augmentation in oxidative capacities and the increased PDH activity suggesting that calcium might play a role in the metabolic shift."

Our study provides evidence that a low dose of resveratrol, close to the amount found in the serum of resveratrol-treated human patients, is able to modify cancer cell metabolism in colon cancer cells, with an alteration of lipidomic profile and a reversion of the Warburg effect. Resveratrol clearly increases the oxidative capacities of cancer cells and decreases the glycolysis. We propose that the PDH complex is a novel target for resveratrol through a Ca2+/AMPK signaling pathway.

This topic was modified 11 months ago by Daniel
This topic was modified 1 month ago by Daniel

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