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Devimistat


dumbcritic
(@dumbcritic)
Joined: 4 years ago
Posts: 100
Topic starter  

It targets enzymes (pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase) in the mitochondria of cancer cells that affect cancer cell energy metabolism, resulting in cell apoptosis and/or necrosis.

 

Trials are currently recruiting in R/R Burkitt lymphoma/leukemia or high-grade B-cell lymphoma with high-risk translocations [1], high risk myelodysplastic syndrome [2], locally advanced pancreatic [3], R/R AML [4] and metastatic pancreatic [5]. Also, ones are planned in R/R T-cell NHL [6], advanced unresectable biliary tract [7], and the company has a compassionate use program [8]. 

 

Refs:

1 https://clinicaltrials.gov/ct2/show/NCT03793140

2 https://clinicaltrials.gov/ct2/show/NCT03929211

3 https://clinicaltrials.gov/ct2/show/NCT03699319

4 https://clinicaltrials.gov/ct2/show/NCT03504410

5 https://clinicaltrials.gov/ct2/show/NCT03504423

6 https://clinicaltrials.gov/ct2/show/NCT04217317

7 https://clinicaltrials.gov/ct2/show/NCT04203160

8 https://rafaelpharma.com/compassionate-use


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dumbcritic
(@dumbcritic)
Joined: 4 years ago
Posts: 100

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dumbcritic
(@dumbcritic)
Joined: 4 years ago
Posts: 100
Topic starter  

An oral form of devimistat (RFL-618) is in development, as are three second generation compounds (RFL-5800/5990/6520). INDs are expected to be filed either this and/or next year.

In the first PhIII (metastatic pancreatic) the company is expecting a data readout by Q3. In the second PhIII (R/R AML), an IA will be conducted by Q2.

Four PhII trials are planned in first-line metastatic pancreatic (dev plus gemcitabine and nab-paclitaxel), metastatic CRC (dev plus FOLFOXIRI and bevacizumab), R/R MDS (dev plus hydroxychloroquine) and R/R TCL (dev plus bendamustine), also a PhI/II in R/R ccSTS (dev plus hydroxychloronquine).


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