Combo Metformin And Syrosingopine!!!! Looks Awesome!  

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Jcancom
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18/06/2019 5:49 am  

Wahoo! If we could take this syrosingopine into a chitosan formulation that could be a turbo-charger. I am generally quite concerned when we change things up with combinations because even when things look fine on paper you can never be sure that something unpleasant might pop up. Chitosan gives you a targeting mechanism that can let you down dose and increase safety and increase efficacy all at the same time.

The patenese is so convoluted in the below url that I have no idea what they are trying to say, though chitosan and syrosingopine did make it onto the same page. I start I suppose. 

It would be such a help if regulators could at some level acknowledge that formulating with chitosan should typically be understood to be GRAS. 

https://patents.google.com/patent/WO2003030818A2/en

(Thank you for the Like Johan. Like you back!

It was tough on the threads and on the forum for quite a few years. Whenever we lost a friend, it was difficult for everyone. I was not sure whether I was making a positive contribution. Yet, together we made it through. We are seeing patient after patient that it is reasonable to suggest have benefited from metabolic strategies. Now there are all these new explorers on forum who can see value in what we have done and are going to search out new discoveries. With metabolic treatment there are so many combinations to try. When we hit the right combo, the entire puzzle could unlock. But you don't know what the combo is until you give it a try.

It is very gratifying to see that our efforts might be help to them.) 

 


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Manuone
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20/06/2019 3:21 pm  

Great contribution J!

I keep working on mitohonokiol. I'm close to getting it. It is possible that by considering it well access other formulations.
I will expand information.
It may be a good idea to exchange opinions by mail? To have more "privacy" on some sensitive topics ... what do you think about this?

kind regards


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Jcancom
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21/06/2019 2:53 am  

Manuone, you made my day!  (Actually my year!)

I know that it can be difficult to make arrangements for synthing (especially when people typically do not have reach into the chemical lab community). However, as you can see (most particularly with mito-HK and others) there can be a very large boost in efficacy and reduction in risk when the proper formulation is adminstered.

I am slightly unsure of the wording you used above, though I believe you said that you might then be able to access other options. Yes! That would certainly be fantastic. There are so many of these formulations that have been written up and hidden away in libraries. Many of them appear to be simpler than mito-HK to synth. Once you get the feel for it, you could open up a great number of possibilities.  

As you noted, it is exciting to see that others on forum have picked up on syrosingopine. Shutting down NADH recycling? Wow! This is a central mechanism of cancer. The entire glycolytic overdrive of cancer is heavily dependent on this process; I am not entirely sure how cancer cells could carry on for long without it.

Gerat thinking about going off thread. I've asked D to help us out on this, so we should be in contact soon.

Wishing you and yours the best, Jcancom   


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Jcancom
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21/06/2019 5:32 am  

Manuone, I have been rereading the literature on POH. This sounds great! On the compass thread there is a recent post that talks of bumping up intranasal daily dosing to over 1,000 mg per day ( dose is divided into 4 4 equal doses through the day. Guess this might qualify as metronomic.) Hundreds of patients have been treated in Brazil and also some in the US. According to Right to Try legislation, this treatment could be available now. Given the results, it would be a good one to look into further. Research found that benefit was extended yet more by adding in ketogenic diet. Best Wishes.


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finnan
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21/06/2019 9:22 pm  

What would happen if you add something like quercetin, simvastatin and (local?)hyperthermia in the mix?


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Manuone
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22/06/2019 6:00 pm  

Dear Jcancom,

I've become comfortable writing in English and the google translator is sometimes crazy!
Use intranasal poh for over a year and it was not effective. It is also an invasive therapy for my mother's current conditions.
I will update the news about mitohonokiol quickly. If I get a good amount and the price is high, I may look for patients interested in acquiring it.
Now I need to think about an important issue such as the supposed cerebral edema of my mother. She improves rapidly with corticosteroids in doses of 2 to 4 mg but I need to remove them as soon as possible.
Daniel and other contacts suggested DMSO IV ... the problem is that I can not find enough information about its intravenous use. I find some old study but they are restricted access. I have seen that it is not as innocuous as it is spoken and can cause side effects such as hemolysis, nausea, vomiting and elevations of liver values ​​.....
It is true that a dose of 2ml of dmso dissolved in saline solution of 100ml is a very low concentration.
I would appreciate it if you shared with me information about dmso iv especially dose and number of bolus in a week.
I do not know if it would be compatible with the other therapies, you know that I handle a very wide cocktail.
I would appreciate help and information friends

kind regards


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Daniel
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22/06/2019 6:37 pm  

Hi Manu,

Regarding DMSO, while waiting for the response of J to your questions, I also like to add the following:

1. It would be good to start another topic with title DMSO
2. DMSO IV is used at Germany clinics several times/week
3. At doses of a few to several ml DMSO/day IV, I haven't heard of any special reaction other than the unpleasant smell from the patient for 12-24h after IV. Some have used even more than 10ml/IV but we never used more than a few to several ml
4. When DMSO was used in combo with Curcumin IV, the dose of Curcumin IV had to be lowered at half the normal dose, as the reaction to Curcumin +DMSO would be very intensive. The conclusion was that DMSO may increase the effectiveness of some drugs. This is why when using DMSO IV I would lower the dose of the drugs used to maybe half, and increase them back towards normal dose step by step. 

Apologizes if there is any repetition, and any of the above statements have been made in my previous comments.

Kind regards,
Daniel


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Manuone
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23/06/2019 1:26 am  

Thank you Daniel for your answer!
I'm less worried about being like that. I hope to handle the situation well and be able to handle the therapy well again.
I am going to introduce lomustine at very low doses on days of 2dg metronomic 30mg / day x 2 days. I will combine it with high doses of DHA that according to one study increases the efficacy of lomustine.
The cocktail looks like this:
- lomustine 30mg + 2dg metronomic + DHA + empty liposomes loaded with 20mg of parthenolide.
- sodium phenylbutyrate 5g
- tamoxifen 60mg
-metformin 1700mg
-doxycycline 200mg
- canagliflozin (far from 2dg)
-simvastatin 20mg
- dca 700mg
-fenfendazole 1g x 3 days
-vitaminad3
- milk thristle 3g
-salinomycin iv
- vitamin c iv
- dmso iv 2-5ml (reducing the amount of drugs)
- mitohonokiol I hope to use it soon.

How is the cocktail?

Thanks for everything!


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johan
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23/06/2019 5:02 am  

Hi Manuel,

Have you considered melatonin? 

https://www.researchgate.net/publication/330346531_Melatonin_and_its_anti-glioma_functions_A_comprehensive_review

Amazing cocktail, there's no doubt your mother is alive today b/c of your exceptional care.

Regards

Johan

 


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johan
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23/06/2019 6:18 am  

Melatonin May Increase Anticancer Potential of Pleiotropic Drugs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320927/

"The results from our laboratory showed that MEL has the potential to elevate the anti-cancer effects of statins. "

 

 


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johan
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23/06/2019 6:23 am  

MEL  anti-inflammatory effects:

https://www.ncbi.nlm.nih.gov/pubmed/29902071


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Daniel
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24/06/2019 3:18 pm  

Hi Manuel, 

You are always very welcome! The cocktail looks very good indeed.

We discussed sometime ago the following:

 
Have you considered any of these? I remember you were looking at Acetozolamide and even use it at some point? They should be specifically relevant for highly glicolitic tumours such as glioblastoma.
 
Kind regards,
Daniel
 
 

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Manuone
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24/06/2019 8:19 pm  

Dear Daniel,

Thank you for your continued help and opinions.
The problem with acetozolamide is its supposed interaction with other drugs and NSAIDs.
I share the list of interactions and I would appreciate your opinion.
https://www.drugs.com/interactions-check.php?interaction_list_id=183194368&drug_list=2145-3709,2092-0,1463-3511,1573-0,940-505,2067-0,3465-0,810-3297,1481- 0.1633-0.1690-1051,1115-0,560-284,894-0,1548-10148,86-0
I have to carefully study syrosingopine and steripentol.

kind regards


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Manuone
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24/06/2019 9:12 pm  

Thousands of thanks Johan!
We used it some time ago and I think it can be helpful again


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Daniel
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27/06/2019 3:21 am  

Hi Manuel,

I checked the list of drugs you shared above with Acetazolamide. According to this there may be moderate interaction with Metformin, Dexamethasone, Canagliflozine. My understanding is that this interaction is related to potential Acetazolamide modulation of blood glucose and blood pH. Acetazolamide can both increase or decrease blood glucose levels. So if I would introduce Acetazolamide I would have an eye on these two, specifically blood glucose levels, and I would introduce it step by step. 

I would also be careful in case it is used and removed at a latter point. I can imagine that the brain tumours may be extra sensitive to Acetazolamide as it is known to modulate cerebral edema, e.g.:

https://www.karger.com/Article/FullText/445170

https://www.frontiersin.org/articles/10.3389/fneur.2019.00273/full

Kind regards,

Daniel


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