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John Pizzuto
(@jpizzuto)
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24/12/2019 3:07 pm  

@marcosbomber901

I ordered it on Sep. 10, received it Nov. 11.  FedEx brought it to my door, though I did have to sign a TSCA form and email the scan to them first.


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GgE
 GgE
(@gge)
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24/12/2019 6:29 pm  
Posted by: @marcosbomber901

local oncothermia, I tried again last year but had no reduction effect on the lung nodules, now with the seroma under the skin oncothermia is contraindicated (would have no effect...})

Sorry about that. I don’t know in your wife’s case but unfortunately, in many types of cancer the tumor cells become resistant to hyperthermia after the first high temperature treatment because the heat activates their heat-shock proteins (HSP). I have not researched whether this resistance gets reduced after some time without repeating the hyperthermia or whether there is a way to avoid it in the first place, or reverse it after it has happened.
Merry Christmas and Happy New Year everybody!


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GgE
 GgE
(@gge)
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24/12/2019 6:57 pm  

https://www.hindawi.com/journals/omcl/2019/4606219/

"As with any cancer treatment,the ability for cancerous cells to adapt to treatments is one of the main issues scientists face. Hyperthermia is no exception to this rule;through the increased expression of stressor molecules such as HSP’s cells can achieve higher and higher rates of thermo-resistance.(Csoboz, et al., 2013)"


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marcosbomber901
(@marcosbomber901)
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24/12/2019 7:30 pm  

@ray-donnelly

Of course I don't know if you can get the mail through the site now, but I will make it available to you


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marcosbomber901
(@marcosbomber901)
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24/12/2019 7:34 pm  

@ray-donnelly

I am also in Spain like you


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Ray Donnelly
(@ray-donnelly)
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24/12/2019 9:14 pm  

@marcosbomber901, My email is my.name at gmail.com

Feel free to drop me a line.

@jpizzuto thanks for the aspirin reminder. I'm also taking that.


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finnan
(@finnan)
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25/12/2019 7:02 am  

@manuone

Just a heads up: I have used silymarin-based products in high dosages over prolonged periodes many times, and every time i have to stop because of a fatigue that develops around month 4-5. 

I havent had any bloodwork done, but it is supposed to have iron binding effects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308202/


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ksh0227
(@ksh0227)
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25/12/2019 7:03 am  

Can anyone suggest where I get a hold of syrosingopine?

Also, can we get mito-Honokiol?


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Manuone
(@manuone)
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25/12/2019 10:40 am  

@finnan

Thanks for the observation. Blood tests do not appear to show deficiencies in ferritin.
On the other hand, iron plays a double role in cancer:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646058/


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John Pizzuto
(@jpizzuto)
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25/12/2019 1:37 pm  

@ksh0227

Ask SteveK on the inspire forum.  He has been working with the supplier to get better delivery times.  Here is his thread:

https://www.inspire.com/groups/american-lung-association-lung-cancer-survivors/discussion/syrosingopine-and-metaformin-kills-cancer-any-body-try/


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marcosbomber901
(@marcosbomber901)
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25/12/2019 6:18 pm  

@ray-donnelly

I can't send my message to your mailbox, it tells me that the address doesn't exist, please put it back.

Kind regards


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marcosbomber901
(@marcosbomber901)
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25/12/2019 6:19 pm  

@jpizzuto

Thank you very much


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Ray Donnelly
(@ray-donnelly)
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26/12/2019 2:39 pm  

@marcosbomber901,

It's just [email protected]


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Jcancom
(@jcancom)
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03/01/2020 3:21 am  

I have been wondering about a syromet + NADH combination. syromet creates an oversupply of NADH as it can no longer be processed by OXPHOS or by LDH. What if one were to then add in yet more NADH?

In another discussion it was noted that NADH even itself has shown anti-cancer effects. Would adding in some more metabolic stress help?

The NAD+/ NADH ratio is the primary redox sensor of the cell. What happens if this were to be pushed hard enough?

JohnnyP, you need to think about Mito-Q.

"A recent study reported that Mito-Q was 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells [26]"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966059/

Being able to buy a mito drug off the shelf as a supplement is an opportunity too good to miss. Any mito drug will be cancer specific due to the differences in the higher mitochondrial cell potential in cancer cells.

Happy New Year everyone!


johan liked
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nissim
(@nissim)
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11/01/2020 10:03 pm  

Hi,

Following my question regarding syrosingopine ability to pass the blood-brain barrier.

Due to what appear to be missing information regarding syrosingopine, Daniel suggested to check the same question regarding reserpine.

So, I found here: 

https://pubchem.ncbi.nlm.nih.gov/compound/Reserpine

"Reserpine is lipid soluble and can penetrate blood-brain barrier"

 

As for my question of a valid reliable source for syrosingopine, I went through all of the above mentioned thread in Inspire but didn't find an answer from SteveK. I sent him a question on that and hope to get his answer.

Anyway, I would appreciate if anyone already have an answer about a valid reliable source for syrosingopine.

 

Regards, Nissim


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John Pizzuto
(@jpizzuto)
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12/01/2020 12:49 am  

Louis Hu is the marketing manager for the Shaanxi Dideu Medichem Company.

As of last month, he was quoting a 25 day lead time if I wanted to reorder.

This is his identifier, copied from my alibaba message page:

https://dideu.en.alibaba.com/product/60814939223-804119194/High_Quality_99_Natural_product_Syrosingopine_CAS_NO_84_36_6_producer.html?spm=a2700.12243863.0.0.88ce3e5fSrbM85


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Daniel
(@daniel)
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Posts: 718
12/01/2020 3:43 pm  

@jpizzuto

Thanks John for sharing this.

To All: On Alibaba we can find both very good quality products but also the opposite. Since here we discuss about drugs that may be key to our survival, it would make sense for anyone to test the product ordered and make sure it is what it was ordered.

I am not sure what is the organisation in US, but in Europe there is a large organisation that offers chemical analysis at very accessible prices https://www.eurofins.com


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GgE
 GgE
(@gge)
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18/01/2020 10:21 pm  
Posted by: @jpizzuto

Shirley's markers

Hi Johnny, did she get her markers this month yet? Can you give us an update on her situation?

Best regards


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Jcancom
(@jcancom)
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21/01/2020 1:04 am  

Gge, thank you for reactivating the thread. It can take some of us a while to recover from New Year's.

Ray, have you received your lactate monitor yet? This could be a big innovation for us this year! If lactate truly can give a fine grained real time indication of response, then this could be extremely helpful. One could then manipulate treatment strategies also in real time for maximal effectiveness. I mentioned this idea in terms of having one's own PET scanner in the driveway, though that would not be realistic for typical patients. However, the lactate monitoring approach could bring similar treatment control into everyone's budget range.


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Jcancom
(@jcancom)
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21/01/2020 1:15 am  

Hmm, this one is not overly surprising though reassuring nonetheless. What they found was that the latest generation of immune check point drugs are inhibited by Warburg metabolic environments. Finding a combination of metabolic and immune approaches might to help amplify both.

https://www.nature.com/articles/s41585-019-0263-6


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John Pizzuto
(@jpizzuto)
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21/01/2020 10:29 am  

@gge

The results of Shirley's latest blood work came in yesterday.  Her cancer antigen marker CA15-3 took a sharp turn upward, going from 138 to 172 this month.  It had been increasing maybe 10 points a month.

Her "Absolute Lymphs" is the only other reading out of range, was 0.5, low normal is 0.7.

Some good news, though, her WBC is 3.5, low normal is 3.4.  First time in the normal range I can remember.

We both had a touch of flu or something  just after Christmas.  I had violent vomiting for several hours, chills, weakness, but no diarrhea.  Wasn't myself for about four days.  Then Shirley had diarrhea for three days and a little vomiting.  She only wanted her pain meds during that time.

The last week or so she's done well taking her syro/med on schedule.  I've been giving her the slow release metformin at 9, then syro at 11.  Dose is 3.9mg syro plus 500mg metformin, twice a day.  But, we missed tonight.  Both of us slept though.  I'll try to get her back on track in the morning.

I've noticed her voice is weaker, and she said she can't cough or sneeze properly.  I'm sure the cancer has taken a good part of her diaphragm.

Followup with her oncologist later today, and her monthy Faslodex and Exgeva injections.  I think they were talking about starting her on another drug.  Shirley turned it down a year ago, fearing the side effects of diarrhea, etc.


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Daniel
(@daniel)
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21/01/2020 2:22 pm  

@jpizzuto

HI John,

When you have time, please have a look at this https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer/#comment-9783 It should not take much of your time.

Kind regards,
Daniel


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Daniel
(@daniel)
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Joined: 5 years ago
Posts: 718
21/01/2020 2:30 pm  
Posted by: @jcancom

Hmm, this one is not overly surprising though reassuring nonetheless. What they found was that the latest generation of immune check point drugs are inhibited by Warburg metabolic environments. Finding a combination of metabolic and immune approaches might to help amplify both.

https://www.nature.com/articles/s41585-019-0263-6

Good one J. Thanks. This is a subjcet we often discussed during the past years and suggested the importance for alkalizing the tumor micro-environment in order to enable the immune system activity https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/


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GgE
 GgE
(@gge)
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21/01/2020 6:17 pm  
Posted by: @jpizzuto

The results of Shirley's latest blood work came in yesterday.  Her cancer antigen marker CA15-3 took a sharp turn upward, going from 138 to 172 this month.  It had been increasing maybe 10 points a month

Sorry to hear that. I was keeping my fingers crossed for her.

Has she taken loratadine in addition to syro and metf all this time or was she on a break?


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John Pizzuto
(@jpizzuto)
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21/01/2020 6:56 pm  

No.  I tried loratadine and cimetadine together about two months ago, but it gave her diarrhea.  I told her that's one of the possible side effects.  She doesn't want to take anything that can cause diarrhea, and is sick of taking pills.  I also have 500mg mebendazole, but only offer it every other day.


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Ray Donnelly
(@ray-donnelly)
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21/01/2020 9:54 pm  

@jcancom

I have received it, and the company was kind enough to send me a free packet of 25 lactate strips.

One thing that's giving me pause from using it is that I wonder if it wouldn't be of more value for someone else (who's just starting syro-metf treatment) to use my device and strips as that would likely be more valuable? 25 strips is not a lot, and therefore I think we want to get as much value from each strip as we can. I am not sure what monitoring protocol we are looking for here and advice is very welcome. If anyone is about to start this treatment and was interested I would definitely consider posting what I have out to them.

Kindest regards,

Ray.


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GgE
 GgE
(@gge)
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22/01/2020 10:38 pm  
Posted by: @jpizzuto

The results of Shirley's latest blood work came in yesterday.  Her cancer antigen marker CA15-3 took a sharp turn upward, going from 138 to 172 this month.  It had been increasing maybe 10 points a month.

Johnny, I know it is difficult to keep the spirit high in the face of discouraging news. But you need to keep in mind that the CA-15-3 is often not a dependable test. Its results can sometimes mean quite a different story than what they seem.

Some potential sources of error:

1- “CA-15-3 concentration can be significantly elevated in patients with vitamin B12 deficiency.” From: Accurate Results in the Clinical Laboratory, 2013. Has Shirley’s vitamin B12 level been tested?

2- “Pancreatitis, Crohn’s disease, ulcerative colitis, and benign gastrointestinal disease may also cause some elevation of CA-15-3 [35].” From Pitfalls in Tumor Markers Testing, by Alyaa Al-Ibraheemi, ... Amer Wahed, in Accurate Results in the Clinical Laboratory, 2013. I wonder if Shirley’s GI problems might cause at least part of the continuous rise.

Assuming the above potential causes for error don’t apply, we need to consider the most important one, which is what gives us all a ray of hope:

3- A sharp rise while she was using drugs that should have a beneficial effect might actually signal a good response to the treatment. When many cancer cells are dying in a short time they break up and release their components (including mucins) in the system. The blood carries heavy loads of their proteins for a while until they are eliminated. Tests done on blood samples taken during this time may find unusual levels of cancer proteins but they cannot tell whether they came from dead or from live cells.

“(CA-15-3) Levels usually fall if treatment is successful, but initially the levels can rise as dead cells release their contents into the blood.” From Cancer Markers, Hoon H. Sunwoo, Mavanur R. Suresh, in The Immunoassay Handbook (Fourth Edition), 2013

Also per “Molecular Oncology of Breast Cancer, Himanshu Joshi, Michael F. Press, in The Breast (Fifth Edition), 2018 Markers for the Management of Advanced/Metastatic Breast Cancers. “According to the ASCO recommendations, biomarkers, including carcinoembryonic antigen (CEA), cancer antigen 15-3 (CA 15–3), and cancer antigen 27-29 (CA 27-29) can be used for making assessments that contribute to clinical decisions in treating patients with metastatic breast cancers, but these may not be used alone for the purpose of therapeutic decisions.233 NCCN recommends that significant increases in these serum markers may indicate disease progression but may also occur in cases of responding disease. Corroboration with patient symptoms and bone scans can be useful in bone dominant disease.231

The syromet doses Shirley is taking seem to be high enough. I believe they must be pounding her tumors and scattering debris all over the place. This havoc has to cause unusual effects on her blood tests that her onco might not interpret realistically for lack of info.

So, I encourage you not to assume the worse. You may get a better picture by adding to the test results the above additional info. Is Shirley feeling better or worse of her lesions (assuming she can separate how she feels as a side effect of the medications)? Will she have a scan any time soon?


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Jcancom
(@jcancom)
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24/01/2020 3:08 am  

JohnnyP, I am sorry that syromet has not shown efficacy to date. It is frustrating that we have not seen even more success with those on forum. It would not be especially unexpected that some day a direct hit to the main line of cancer metabolism might be announced with extreme anti-cancer effects. Along the lines of a dual targeting of the main energy power supply as D wrote in his recent article with a good formulation. The  would probably be massive.

When you read the cancer literature, metabolics is simply everywhere. There is a near supersaturation of metabolics in cancer research. It is everywhere! There really can be no doubt: Cancer can be understood as a metabolic disease. There might be other conceptions, though as in terms of its primary essence, it is metabolic.

Lately, I have been reading about the role of aluminum in breast cancer (especially through anti-antiperspirants) aluminum apparently has a metabolic effect; it can be removed with silicade, the combination of 3-BP and methyl jasmonate, metformin as an HK inhibitor (!!!) 

 

{I had been wondering which drug might be good as a mitocan; mito-metformin might be an especially good choice as it can target both OXPHOS subunit 1 and HK. I believe marcos mentioned mito-metformin in one of his recent posts.  Dual combination of mito drugs such as mito-honokiol and mito-metformin could be an extraordinarily powerful combination. And HK-2 is bound to the mitochondria specifically in cancer (as far as I aware), so this could be a highly cancer specific approach.}

 

Also read about TRIM59 with 3-BP in ovarian cancer. Metabolics! When TRIM59 is upregulated glucose metabolism is enhanced, ovarian cancer patients have shorter life expectancies with overexpression of TRIM59. We have seen this time and time again, MCT-1 is upregulated, TRIMp59 is upregulated; this is a bad prognostic. Then you treat with 3-BP and in the patients with poor expected outcomes there can be good outcomes. Same with TRIM59. Mice with overexpressed TRIM59 saw substantial responses with 3-BP treatment, not that much response in the mice with typical TRIM59 treated with 3-BP. 

 

JohnnyP, I greatly wish that this will be the year that you will be able to find an effective treatment for your wife. There are almost endless suggestion on this site to consider.

All the Best for 2020, J

       


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Jcancom
(@jcancom)
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24/01/2020 3:32 am  

Ray, could you give us a reading on your lactate levels? I think that now that you have the strips, the best use that you could make of them is to report back on your levels. If this works to plan this could of much help to other people. If you could show that there were a rapid lactate response to syromet or other treatments this could have substantial relevance to other patients. Perhaps next time you dose with syromet, take a baseline lactate level (possibly even 2) and then see what happens after a dose (might want to do 2 measures). This might take up your excess supply somewhat quickly. Knowing how lactate responded would be valuable. You might then be able to time a combination that would be particularly effective. However, this will need to be determined through the testing and might take a while.    


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Jcancom
(@jcancom)
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24/01/2020 4:59 am  

This is a great blog about DCA and it considers the full range of combinations in the DCA universe. Very impressed. It is a very good idea to develop an understanding of treatments that can be applied all along the glycolytic/OXPHOS pathway. The post discusses a large number of approaches of targeting VDAC-HK-2. This is a good point to focus on as it is cancer specific. A formulation such as mito-DCA could greatly magnify the effect. Good point in the article about avoiding neurotoxicity by nebulizing or IV. 

https://jeffreydachmd.com/2019/11/dca-dichloroacetate-breakthrough-anticancer-agent/


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