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The lipid association improves the therapeutic index of lomustine


Manuone
(@manuone)
Joined: 4 years ago
Posts: 148
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https://cancerres.aacrjournals.org/content/61/9/3669.long

This is precisely what I want to do with lomustina. Considering that the usual doses are 110-130 mg x m2. In my mother's case it would be a 143/169 mg dose of lomustine. Using the dose that I have thought of 60 mg (30mg + 30mg) dissolved in empty liposomes with a small mini-mixer.

I trust my friend Pedro González's liposomes for encapsulation and on the other hand I could also use chloroquine to "saturate macrophages".

The efficacy should be greatly amplified with far fewer side effects. I will use as a prevention a dose of antiemetic like ondansetron.
I would appreciate any opinion on my ideas as well as any important information that I am missing.

Kind regards


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johan
(@j)
Joined: 3 years ago
Posts: 590
 

Looks good, Manuel!

Concerning possible adverse effects fro lomustine, here are results from a recent clinical trial.

Clinical trial https://clinicaltrials.gov/ct2/show/results/NCT00777153

Lomustine 110mg Serious Adverse Events

Pulmonary Embolism 3/64 (4.69%)
Thrombocytopenia 2/64 (3.13%)
Hyperglycaemia 2/64 (3.13%)
Convulsion 2/64 (3.13%)
Diarrhoea 1/64 (1.56%)
Pyrexia 1/64 (1.56%)
Sepsis 1/64
Head Injury 1/64 (1.56%)
Cerebral Cyst 1/64 (1.56%)
Cerebral Haematoma 1/64 (1.56%)
Syncope 1/64 (1.56%)
Mental Status Changes 1/64 (1.56%)
Suicide Attempt 1/64 (1.56%)
Dyspnoea Exertional 1/64 (1.56%)
Deep Vein Thrombosis 1/64 (1.56%)

Best regards,

Johan


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Manuone
(@manuone)
Joined: 4 years ago
Posts: 148
Topic starter  

@johan

Thanks johan! I hope there are practically no side effects with such a small dose 🙂


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johan
(@j)
Joined: 3 years ago
Posts: 590
 

@manuone I hope so to! My father-in-law did 6 rounds of CCNU with no adverse side effects.


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