The lipid association improves the therapeutic index of lomustine
This is precisely what I want to do with lomustina. Considering that the usual doses are 110-130 mg x m2. In my mother's case it would be a 143/169 mg dose of lomustine. Using the dose that I have thought of 60 mg (30mg + 30mg) dissolved in empty liposomes with a small mini-mixer.
I trust my friend Pedro González's liposomes for encapsulation and on the other hand I could also use chloroquine to "saturate macrophages".
The efficacy should be greatly amplified with far fewer side effects. I will use as a prevention a dose of antiemetic like ondansetron.
I would appreciate any opinion on my ideas as well as any important information that I am missing.
Looks good, Manuel!
Concerning possible adverse effects fro lomustine, here are results from a recent clinical trial.
Clinical trial https://clinicaltrials.gov/ct2/show/results/NCT00777153
Lomustine 110mg Serious Adverse Events
Pulmonary Embolism 3/64 (4.69%)
Thrombocytopenia 2/64 (3.13%)
Hyperglycaemia 2/64 (3.13%)
Convulsion 2/64 (3.13%)
Diarrhoea 1/64 (1.56%)
Pyrexia 1/64 (1.56%)
Head Injury 1/64 (1.56%)
Cerebral Cyst 1/64 (1.56%)
Cerebral Haematoma 1/64 (1.56%)
Syncope 1/64 (1.56%)
Mental Status Changes 1/64 (1.56%)
Suicide Attempt 1/64 (1.56%)
Dyspnoea Exertional 1/64 (1.56%)
Deep Vein Thrombosis 1/64 (1.56%)
Thanks johan! I hope there are practically no side effects with such a small dose 🙂
@manuone I hope so to! My father-in-law did 6 rounds of CCNU with no adverse side effects.