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Starved cancer cells more sensitive to chemotherapy


johan
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Joined: 3 years ago
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Daniel
(@daniel)
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Posted by: @johan

Article: https://www.lunduniversity.lu.se/article/starved-cancer-cells-became-more-sensitive-to-chemotherapy

Study: http://www.haematologica.org/content/early/2020/06/15/haematol.2020.246843

Thank you Johan.

This is a very nice article supporting concepts that we have discussed for such a long time. Unfortunately, these kind of findings have been presented decades ago in clinical context and have not been applied yet as part of conventional protocols. One such example is Phlorizin https://www.cancertreatmentsresearch.com/phlorizinphloretin-a-strong-glucose-transport-inhibitor/

With this I would also like to point out that the title chosen by scientists here "Starved cancer cells more sensitive to chemotherapy" may be misleading. 

I went through the study, and it seems that they applied chemo and the GLUt inhibitors in combination, while starving may imply that this has been achieved prior to applying chemo. 

As we discussed in other comments and posts on this website, it possible that when we starve cancer prior to applying chemo, the effectiveness of chemo may be actually reduced (since chemo "targets" fast dividing cells), while when applied at the same time chemo and e.g. Metformin, chemo effectiveness increases. There was a PhD thesis in breast cancer that I cited supporting this concept.

This is very important point in my view that all should be aware of - I should actually write an article on this to highlight the concept since so many people are going for starving cancer. (as a note, in my view diet requires a different discussion.)

Kind ergards,
Daniel

 

This post was modified 1 year ago by Daniel

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Kimster
(@kimster)
Joined: 2 years ago
Posts: 115
 
Posted by: @daniel

As we discussed in other comments and posts on this website, it possible that when we starve cancer prior to applying chemo, the effectiveness of chemo may be actually reduced (since chemo "targets" fast dividing cells), while when applied at the same time chemo and e.g. Metformin, chemo effectiveness increases. There was a PhD thesis in breast cancer that I cited supporting this concept.

This is very important point in my view that all should be aware of - I should actually write an article on this to highlight the concept since so many people are going for starving cancer. (as a note, in my view diet requires a different discussion.)

Kind ergards,
Daniel

 

Hi Daniel, thank you very much for sharing to highlight this "very important" point/concept.

 

Thanks.

Kimster


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