Macrophages may reduce chemo's results - Chloroquine can stop that
Many cancer patients do not respond to chemotherapies because the drugs never reach the cancer cells. Even in nanomedicine, which is one of the best new methods for delivering drugs to a tumor, only about one percent of a dose of nanoparticles will successfully arrive at the intended tumor site, while the rest are filtered out by the immune cells of the liver and spleen.
Using chloroquine, the researchers not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumors. The study was recently published in Scientific Reports, a research journal from the Nature Publishing Group.
Seems like it's helpful in many ways, but the possible side effects are scary. I wonder if it's possible to check any genetic traits to know how the body will react. COMT should call for lower doses if I assume correctly.
In my view, Chloroquine and Hidroxychloroquine are coming with a relatively good safety profile compared to most of the drugs used in the oncology space. It's safe enough to be taken by those travelling in countries with malaria risk https://www.cancertreatmentsresearch.com/chloroquine-hydroxychloroquine/