Dead and dying cancer cells killed by conventional cancer treatments trigger inflammation that promotes tumor growth and metastasis.
Dead and dying cancer cells killed by conventional cancer treatments paradoxically inflammation that promotes tumor growth and metastasis.
Recently, scientists have proposed a novel approach to suppressing chemotherapy-induced tumor growth. More specifically, scientists have synthetized a drug that can inhibit both the cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) pathways responsible for the debris-induced surge of both cytokines and lipid mediators by macrophages, that are connected to chemotherapy induced tumor growth.
While we do not have access to this newly synthetized drug, we can find drugs and supplements that can inhibit or reduce cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH).
- Celecoxib (Celebrex) is a well known inhibitor of cyclooxygenase-2 (Ref.)
- Honokiol, an extract from magnolia found online as a supplement is a sEH inhibitor (Ref.)
- another sEH inhibitor is β-amyrin acetate (Ref.) which is found in the Alstonia boonei bark (Ref.), commonly used in West and Central Africa along with other herbs in the management of arthritis (Ref.)
Therefore, combining Celecoxib (drug) and Honokiol or beta-amyrin (supplements) may help avoid chemo induced tumour growth.