Grade 1/2 FL
 
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Grade 1/2 FL

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jjshein
(@jjshein)
Joined: 3 years ago
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Hi all,

I received my dx of indolent follicular lymphoma, grade 1/2 in August, 2019, and have been on W&W since then.  I had a single (right inguinal) lymph node (excisional) biopsy to confirm FL, PET scan negative, bone marrow biopsy positive.  Otherwise, I remain asymptomatic.  I'm currently scheduled for bloodwork in mid-April for follow-up with my oncologist.

Where should I start from a dietary/supplement standpoint to help keep this monster at bay?  56(M), healthy other than chronic back pain.  My lab pathology for the biopsied lymph node is copied below.

Thanks.

Jon

Surgical Pathology Outside Consultation

Location: MGHPATHOLG
Institution: MGH
Date of Accession: 9/21/2019
Reported: 9/23/2019 11:30
Results To:

FINAL PATHOLOGIC DIAGNOSIS:
A. RIGHT INGUINAL LYMPH NODE EXCISIONAL BIOPSY (S19-5798- A1-A4; 08/29/2019):
Follicular lymphoma, follicular pattern, grade 1 to 2 of 3 (see note).

Note: The specimen is a slightly enlarged lymph node that is almost entirely
replaced by a proliferation of crowded, poorly-delineated follicles composed of
centrocytes and occasional centroblasts, with fewer than 15 centroblasts per hpf
in a background of centrocytes. The follicles largely lack polarization and have
few mitoses. Mantles are attenuated to absent. Patent sinuses are infrequent.
The atypical follicles invade the capsule, where they are associated with
fibrous thickening and reduplication of the capsule. Atypical follicles invade
perinodal fat.

Immunostains show numerous B cells (CD20+) in a follicular pattern. B cells in
follicles co-express CD10, Bcl6, and Bcl2. There are many interfollicular T
cells (CD3+). Ki67 (proliferation) shows variable staining, with some follicles
showing up to 40% positivity in follicular cells; some residual reactive
follicles are also present, which may account for the increased proliferation
index. Per report, concurrent flow cytometry performed at the outside hospital
demonstrates a CD10+ B-cell lymphoma, consisting of clonal CD20+ B-cells that
coexpress CD10 and dim kappa light chain, are negative for CD5 and CD11c, and
comprise 45% of lymphocytes.

The histologic and immunophenotypic features together support a diagnosis of
follicular lymphoma.


   
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