Hi friends, just came across the following type of herbal medicine, so just sharing here:
https://www.sciencedirect.com/science/article/pii/S0378874119346975
Proteomics analysis of tumor exosomes reveals vital pathways of Jinfukang inhibiting circulating tumor cells metastasis in lung cancer
Available online: 30 March 2020
Abstract
Ethnopharmacological relevance
Jinfukang has long been used for the clinical treatment of lung cancer.
Previous studies have shown that Jinfukang can induce the apoptosis of circulating tumor cells by intervening ROS-mediated DNA damage pathway.
However, whether Jinfukang can inhibit the metastasis of circulating tumor cells and its mechanism are still unclear.
Aim of the study
To further investigate the mechanism of Jinfukang in anti-metastasis of lung cancer from the perspective of intervention of tumor exosomes.
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Conclusion
Jinfukang inhibits the metastasis of CTC-TJH-01 cells through the EGF pathway.
https://www.sciencedirect.com/science/article/abs/pii/S0378874120333596
Jinfukang regulates integrin/Src pathway and anoikis mediating circulating lung cancer cells migration
Available online: 15 October 2020
Abstract
Ethnopharmacological relevance
Metastasis is the main cause of death in lung cancer patients.
Circulating tumor cells (CTCs) may be an important target of metastasis intervention.
Previous studies have shown that Jinfukang could prevent the recurrence and metastasis of lung cancer, and we have established a circulating lung tumor cell line CTC-TJH-01.
However, whether Jinfukang inhibition of lung cancer metastasis is related to CTCs is still unknown.
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Conclusions
Our results indicate that the migration and invasion of CTCs are inhibited by Jinfukang, and the mechanism may involve the suppression of integrin/Src axis to induce anoikis.
These data suggest that Jinfukang exerts anti-metastatic effects in lung cancer may through anoikis.
https://www.cancer.gov/publications/dictionaries/cancer-drug/def/jin-fu-kang
Jin Fu Kang
A traditional Chinese herbal medicine derived from the plant Astragalus membranaceus with potential immunopotentiation activity.
Jin Fu Kang may stimulate anti-tumor macrophage and natural killer cell activity and may enhance immune recognition of tumor cells by inhibiting the production of T-helper cell type 2 (Th2) cytokines such as interleukin-4 (IL-4) amd interleukin-10 (IL-10).
Thanks.
Kimster
Thank you Kim!
Have a very nice Sunday! 😊
Kinde rgards,
Daniel
Hi Daniel, thank you for your "liked" 🙂
I learnt "Exosomes" from your latest great article:
https://www.cancertreatmentsresearch.com/exosomes-in-cancer/
Exosomes: The Inter-cellular Communication System
and then the following year 2020 article, with herbal medicine information, mentions "tumor exosomes", so I just created this new topic 🙂
https://www.sciencedirect.com/science/article/pii/S0378874119346975
Proteomics analysis of tumor exosomes reveals vital pathways of Jinfukang inhibiting circulating tumor cells metastasis in lung cancer
Available online: 30 March 2020
Wish you have a very nice Sunday as well 🙂
Thanks.
Kimster
