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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis


johan
(@j)
Joined: 3 years ago
Posts: 631
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Published:June 27, 2019 DOI: https://doi.org/10.1016/j.cell.2019.06.005

Highlights

  • Antioxidants stimulate KRAS-driven lung cancer metastasis
  • Antioxidants reduce free heme levels and stabilize BACH1
  • BACH1 activates Hk2 and Gapdh transcription triggering glycolysis-induced metastasis
  • Targeting BACH1 or its glycolytic targets prevents antioxidant-induced metastasis

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Yudaitheska
(@yudaitheska)
Joined: 3 years ago
Posts: 32
 
Posted by: johan

Published:June 27, 2019 DOI: https://doi.org/10.1016/j.cell.2019.06.005

Highlights

  • Antioxidants stimulate KRAS-driven lung cancer metastasis
  • Antioxidants reduce free heme levels and stabilize BACH1
  • BACH1 activates Hk2 and Gapdh transcription triggering glycolysis-induced metastasis
  • Targeting BACH1 or its glycolytic targets prevents antioxidant-induced metastasis

Dr. Budwig always advised to not mix artificial antioxidants along with her prooxidant therapy other than what her patients would get from food... Interesting. Now we can see more Insight about her observations. Again the future of cancer treatment seems to be the better understanding of the old therapies


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