Antibiotic drug rifabutin is effective against lung cancer
"Rifabutin is a semisynthetic antibiotic derived from the rifamycins, and primarily used to treat tuberculosis . It kills bacterial by blocking the DNA-dependent RNA synthesis . Our encounter with a non-small cell lung cancer patient combined with pulmonary tuberculosis, who showed blunted tumor progression while receiving rifabutin, prompted us to study the possible effects of rifabutin in lung cancer cells. We are the first to reveal that rifabutin inhibits proliferation and induces apoptosis of EGFR-mutated lung cancer cells in vitro and in vivo. Importantly, we show that the inhibitory effects of rifabutin in lung cancer cells are attributed to its inhibition of eIF4E-b-catenin signaling pathway."