Antibiotic drug rif...
 

Antibiotic drug rifabutin is effective against lung cancer  

  RSS

Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 392
13/12/2018 2:04 pm  

"Rifabutin is a semisynthetic antibiotic derived from the rifamycins, and primarily used to treat tuberculosis [9]. It kills bacterial by blocking the DNA-dependent RNA synthesis [10]. Our encounter with a non-small cell lung cancer patient combined with pulmonary tuberculosis, who showed blunted tumor progression while receiving rifabutin, prompted us to study the possible effects of rifabutin in lung cancer cells. We are the first to reveal that rifabutin inhibits proliferation and induces apoptosis of EGFR-mutated lung cancer cells in vitro and in vivo. Importantly, we show that the inhibitory effects of rifabutin in lung cancer cells are attributed to its inhibition of eIF4E-b-catenin signaling pathway."

https://www.sciencedirect.com/science/article/pii/S0006291X16303084


Quote
ronakprjpt
(@ronakprjpt)
New Member
Joined: 2 months ago
Posts: 3
17/07/2019 4:30 pm  

hi daniel

my father was diagnosed with stage four lung adenocarcinoma and stage two tongue cancer

yes two different cancers

for lung cancer he is on irresa and seems to help.. but the tongue cancer is back and also started developing malingnant pleural effusion,which means iressa not working anymore, which are the best repurpose medicines as per your opinion which  we should start considering starting to give him , 


ReplyQuote
Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 392
25/07/2019 10:20 am  

@ronakprjpt

Hi Rona, sometime ago I was in contact with someone with tongue cancer who was applying topically a solution containing 3BP https://www.cancertreatmentsresearch.com/3-bromopyruvate/

As soon as I get the chance I will contact him to see how he is doing but at that time (and for long time) he had very good response.

Kind regards,
Daniel


ReplyQuote
ronakprjpt
(@ronakprjpt)
New Member
Joined: 2 months ago
Posts: 3
25/07/2019 12:42 pm  

@daniel

thanks alot for the reply

want your expertise on managing malingnant pleural effusion caused by lung adenocarcinoma and best combinations of repurposed medicines to manage the lung cancer and the effusion..

considering starting my father on JOE TIPPENS PROTOCOL, but the more i read, i see less success stories on that, and also the link between vitamin e and increase of lung cancer .

thanks regards


ReplyQuote
Daniel
(@daniel)
New Member Admin
Joined: 4 years ago
Posts: 392
29/07/2019 4:55 pm  

@ronakprjpt

If in doubts about Vit E just don't use. That is my rule with anything. Regarding Fenbendazole, we can not expect to find much success stories at this point, beyond Joe and his contacts. It is a treatment approach that was unknown for most until very recently, so patients just started considering to use it. The science, the anecdotes and the case reports from anticancer effects of similar drugs (such as Mebendazole) points towards chance of effectiveness, so we may see more Joe-like stories in the coming years.

Regarding pleural effusion, you may want to consider the following:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004388/
- https://www.ncbi.nlm.nih.gov/pubmed/15114711
- https://www.cancertreatmentsresearch.com/treating-ascites-with-angiogenesis-inhibitors/
- angiogenesis inhibitors may help https://www.cancertreatmentsresearch.com/category/angiogenesis-inhibitors/

Kind regards,
Daniel


ReplyQuote
ronakprjpt
(@ronakprjpt)
New Member
Joined: 2 months ago
Posts: 3
30/07/2019 8:08 am  

@daniel

thanks again for the reply, my father is on aspirin 75 and losartan 50mg for his blood pressure

the regime am considering putting him on

mebendazole 100mg+ cimetidine400mg + celecoxib100mg *2 daily

azithro 500mg + doxy 100mg+vitamin c 1gm  *2 daily

febendazole 300mg once daily

whats your take on the above ,, any addition or subtraction as per your knowledge

Regard Ronak

 


ReplyQuote
Share: