Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells
"We identified a group of antihistamines (termed ANHAs) with distinct physicochemical properties associated with their cationic-amphiphilic nature, that selectively killed leukaemic cells. ANHAs behaved as antileukaemic agents against primary AML samples ex vivo, sparing healthy cells. Moreover, ANHAs severely impaired the in vivo leukaemia regeneration capacity. "
Thanks Johan! Here is another useful article on antihistamine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972561/
Antihistamine it's an important category of drugs to be repurposed for oncology. There are several anti cancer mechanisms behind including the lysosomal-related one but also immune system modulation https://www.cancertreatmentsresearch.com/antihistamine/ and anti MDR modulation.
I found interesting the lysosomal disruption and it's relation with mTOR and will zoom in on to that asap.