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Pseudouridine: What is it and Why Should you Care?

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(@j)
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The Nobel Prize in Physiology or Medicine was awarded for discovering use of Pseudouridine to suppress immune responses to synthetic mRNA, and use of that discovery in COVID-19 mRNA vaccines.

https://rwmalonemd.substack.com/p/pseudouridine-what-is-it-and-why


   
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(@rosed)
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PSEUDO...... that's all I need to know.


   
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(@j)
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Posted by: @rosed

PSEUDO...... that's all I need to know.

lol!

 

 


   
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(@j)
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Posted by: @j

The Nobel Prize in Physiology or Medicine was awarded for discovering use of Pseudouridine to suppress immune responses to synthetic mRNA, and use of that discovery in COVID-19 mRNA vaccines.

https://rwmalonemd.substack.com/p/pseudouridine-what-is-it-and-why

more context: https://www.youtube.com/watch?v=PnJ5T1Enwq4

 


   
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(@j)
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Posted by: @j

Posted by: @j

The Nobel Prize in Physiology or Medicine was awarded for discovering use of Pseudouridine to suppress immune responses to synthetic mRNA, and use of that discovery in COVID-19 mRNA vaccines.

https://rwmalonemd.substack.com/p/pseudouridine-what-is-it-and-why

more context: https://www.youtube.com/watch?v=PnJ5T1Enwq4

 

Around the 10-minute mark, Professor Angus Dalgleish, MD, FRCP, FRCPA, FRCPath, FMedSci says "The T-cells control this disease [cancer]". 

The professor talks about the importance of Vitamin D, from his observations during his long career as an oncologist he noted that it is vital to have a Vitamin D level close to or above 100 nmol/L (which is 40 mg/mL).

Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer

https://www.frontiersin.org/articles/10.3389/fimmu.2019.01307/full

"We show that vitamin D decreases breast cancer tumor growth. Immunomonitoring of the different immune subsets in dissociated tumors revealed an increase in tumor infiltrating CD8+ T cells in the vitamin D-treated group. Interestingly, these CD8+ T cells exhibited a more active T cell (TEM/CM) phenotype. However, in high-fat diet conditions, we observed an opposite effect of vitamin D on breast cancer tumor growth, associated with a reduction of CD8+ T cell infiltration."

I've posted the following study before and it's worth posting again:

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

https://www.biorxiv.org/content/10.1101/2022.05.25.493422v1.full

 "We demonstrate that enhancing ammonia clearance reactivates T cells, decreases tumor growth, and extends survival. Moreover, decreasing tumor-associated ammonia enhances anti-PD-L1 efficacy. Our findings indicate that ammonia detoxification can reactivate T cells, highlighting a new approach to enhance the efficacy of immunotherapies."

What Foods Can Increase T Cells?

https://www.marham.pk/healthblog/what-foods-can-increase-t-cells/

Professor Dalgleish also noted the importance of an anti-inflammatory diet.

 


   
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(@j)
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one of the issues with m R N A vac. that has been observed is increased igg4, Professor Angus Dalgleish also briefly mentions it in the video. In this study, "High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448067/ the researchers found that galectin-3 levels were 13-fold higher in IgG4-related pancreatitis. And we know high levels of galectin3 can produce heart failure and are also enhanced in cancer.

Inhibiting Galectin 3 might be a good strategy to address the issue with the higher levels of igg4.


   
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(@j)
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Here are a few options to inhibit galectin-3: MCP, curcumin, spiraeoside (red onions), QiShenYiQi, formic acid (apples, strawberries, raspberries, honey, nettles).


   
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(@rosed)
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@j Excellent advise, Johan!!!!!  This professor's got it going on!!!!!!!!!  A real research scientist/medical doctor who actually wants to cure his patients!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!  Can we clone him??????????  Thanks for posting and for your additional helpful suggestions and reminders!!!!


   
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(@rosed)
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@j They have rendered the Nobel prize completely worthless.


   
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(@j)
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@rosed 

indeed, it has become excessively influenced by politics.


   
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(@j)
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Posted by: @j

Here are a few options to inhibit galectin-3: MCP, curcumin, spiraeoside (red onions), QiShenYiQi, formic acid (apples, strawberries, raspberries, honey, nettles).

Effects of Aspirin and Indomethacin on Galectin-3

https://core.ac.uk/reader/14374990

 


   
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(@j)
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Posted by: @j

Posted by: @j

Here are a few options to inhibit galectin-3: MCP, curcumin, spiraeoside (red onions), QiShenYiQi, formic acid (apples, strawberries, raspberries, honey, nettles).

Effects of Aspirin and Indomethacin on Galectin-3

https://core.ac.uk/reader/14374990

 

Nigella sativa seed reduced galectin-3 level and liver fibrosis in thioacetamide-induced liver injury in rats

 


   
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(@rosed)
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@j Taking plenty of my Nigella, hahahah!!!  Question for you.... have you seen much on mustard seed?  A little bird whispered that to me today.  It's in the bible... so.....    I mean I know it is related to cruciferous vegetables, but what about the little mustard seed itself.  I see a few things.... 

 


   
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(@j)
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Posted by: @rosed

@j Taking plenty of my Nigella, hahahah!!!  Question for you.... have you seen much on mustard seed?  A little bird whispered that to me today.  It's in the bible... so.....    I mean I know it is related to cruciferous vegetables, but what about the little mustard seed itself.  I see a few things.... 

 

@rosed great! Good question, and in fact I haven't come across much about mustard seeds, not anything I can remember other than what you mention regarding their use with broccoli.

Talking about the bible, I was looking at cancer and disease in history and many diseases are mentioned in the bible but nothing that resembles cancer really. 

I'm curious now, what are you seeing 😉

 


   
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(@j)
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Posted by: @j

Posted by: @j

Posted by: @j

The Nobel Prize in Physiology or Medicine was awarded for discovering use of Pseudouridine to suppress immune responses to synthetic mRNA, and use of that discovery in COVID-19 mRNA vaccines.

https://rwmalonemd.substack.com/p/pseudouridine-what-is-it-and-why

more context: https://www.youtube.com/watch?v=PnJ5T1Enwq4

 

Around the 10-minute mark, Professor Angus Dalgleish, MD, FRCP, FRCPA, FRCPath, FMedSci says "The T-cells control this disease [cancer]". 

The professor talks about the importance of Vitamin D, from his observations during his long career as an oncologist he noted that it is vital to have a Vitamin D level close to or above 100 nmol/L (which is 40 mg/mL).

Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer

https://www.frontiersin.org/articles/10.3389/fimmu.2019.01307/full

"We show that vitamin D decreases breast cancer tumor growth. Immunomonitoring of the different immune subsets in dissociated tumors revealed an increase in tumor infiltrating CD8+ T cells in the vitamin D-treated group. Interestingly, these CD8+ T cells exhibited a more active T cell (TEM/CM) phenotype. However, in high-fat diet conditions, we observed an opposite effect of vitamin D on breast cancer tumor growth, associated with a reduction of CD8+ T cell infiltration."

I've posted the following study before and it's worth posting again:

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

https://www.biorxiv.org/content/10.1101/2022.05.25.493422v1.full

 "We demonstrate that enhancing ammonia clearance reactivates T cells, decreases tumor growth, and extends survival. Moreover, decreasing tumor-associated ammonia enhances anti-PD-L1 efficacy. Our findings indicate that ammonia detoxification can reactivate T cells, highlighting a new approach to enhance the efficacy of immunotherapies."

What Foods Can Increase T Cells?

https://www.marham.pk/healthblog/what-foods-can-increase-t-cells/

Professor Dalgleish also noted the importance of an anti-inflammatory diet.

 

 

 

 


   
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(@j)
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Study finds hallmarks of T cell exhaustion within hours of tumor exposure

https://www.sciencedaily.com/releases/2023/08/230803112958.htm


   
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(@j)
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Posted by: @j

one of the issues with m R N A vac. that has been observed is increased igg4, Professor Angus Dalgleish also briefly mentions it in the video. In this study, "High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448067/ the researchers found that galectin-3 levels were 13-fold higher in IgG4-related pancreatitis. And we know high levels of galectin3 can produce heart failure and are also enhanced in cancer.

Inhibiting Galectin 3 might be a good strategy to address the issue with the higher levels of igg4.

confirmation of the igg4/galectin-3 link:

IgG4 + surprise theory of Galectin 3

https://www.youtube.com/watch?v=3RawyiNo7zY

 


   
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