Hi friends, just sharing the following here:
https://science.sciencemag.org/content/370/6516/eaaz0868
Physical traits of cancer
30 Oct 2020
The biological and physical properties of tumors contribute to their growth and to treatment outcome.
Although intense research efforts have helped to delineate cancer biology, the physics of cancer has only emerged in relatively recent times as a key area of research.
Nia et al. reviewed the physical features that are common to tumors and that limit successful treatment: solid stresses, interstitial fluid pressure, stiffness (rigidity), and architecture and organization of tumor constituents.
The authors provide a conceptual framework and discuss the origins of these distinct physical traits of cancer and how they enable and synergize with aberrant cancer biology to fuel cancer initiation, progression, immune evasion, and treatment resistance.
BACKGROUND
Historically, cancer has been considered a disease of the cell, caused by mutations in genes that control proliferation, differentiation, and death.
In recent decades, however, the microenvironment surrounding the cancer cell has gained notoriety as a coconspirator in tumor initiation, progression, immune evasion, and treatment response.
As tumors grow, they disrupt the structure and function of the surrounding tissue via physical and biochemical mechanisms.
The resulting physical abnormalities affect both cancer cells and their microenvironment and fuel tumorigenesis and treatment resistance.
The links between cancer biology and physics have provided opportunities for the discovery of new drugs and treatment strategies.
Thanks.
Kimster
Kimster, I am very glad that you have taken the metabolic ball and are running with it. After all of the years that we have been posting about metabolic cancer strategies, I do not believe that there is any longer anything even worth arguing about: Metabolic cancer when (if?) it finally arrives will provide a curative option. The one confusing part for many of us is to cope with the oceans of high quality metabolic research that is available.
Here is ANOTHER!! 3-BP formulation with considerable potential potency. It uses the folic acid receptor so it does not even need MCT-1 (Whoa!). There are so many of these formulations now it is stunning. The preparation method that they describe below appears so simple. The high pressure homogenizer might be somewhat tricky to arrange, yet everything else seems very basic.
Not having to be limited by MCT-1 certainly begins to offer the potential of an amplified version of 3-BP. Nevertheless, I would like to see one of these formulations that took it to the next step and added another layer of protection; make it into a 2 or 3 stage formulation. For instance, perhaps they could coat the cubosome in chitosan or turn it into a prodrug. I am not aware of a 3-BP prodrug formulation yet. Adding in another level of safety would be comforting. We know that 3-BP will attack virtually everything inside the cell; we just want to be very sure that it is attacking exclusively cancer cells. Some of these formulations actually seem to have shown this in vivo, however, even more safety (if possible) would be appreciated.
https://pubmed.ncbi.nlm.nih.gov/32956335/bh
Hi friend 🙂
Thank you for your post & information sharing 🙂
I was "really lucky" that I came across this great website created by Daniel, so that I could start to learn & gain more "practical (from Research to Application)" knowledge about Cancer Treatments from this great website - with many post/discussion contributions from friends like YOU, Jcancom 🙂
From Google: Is cancer a metabolic or genetic disease?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535307/
https://www.hindawi.com/journals/omcl/2019/7831952/
- already shared by one of the friends in this forum:
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Many more relevant information...
I'm "still learning", so hopefully I've shared information which would be useful, as reference, for friends visiting this website 🙂
Thanks.
Kimster
