"Astragalus root contains a variety of immunoactive constituents. Its power as an antitumor root is not only due to its immunomodulatory activity; it is able to modulate several apoptotic and antiangiogenic signaling pathways and interact with specific transcription molecules. We propose a rational model of the combination of CPI (Checkpoint inhibitors) with Astragalus root chosen as representative of traditional immunotherapy, to set a paradigmatic frame to develop novel target-specific combinations with natural immunomodulators. We are convinced that by combining these two strategies in immunotherapy—the new one and the old one—we can definitely overcome immune cell exhaustion, boost the response to immunocheckpoint treatment, and minimize side effects, to get better and more efficient results in cancer immunotherapy."
