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IV Vit C


dumbcritic
(@dumbcritic)
Joined: 4 years ago
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High-dose Vit C delayed cancer growth in immunocompetent mice with a range of different solid tumours in a T-cell-dependent manner. It enhanced the efficacy of certain checkpoint inhibitor drugs, induced activation and infiltration of T-cells in the tumour microenvironment, and helped to develop immunological memory. In mismatch repair-deficient tumours refractory to anti-CTLA-4 (Yervoy) alone, the combination of both led to complete tumour regression https://stm.sciencemag.org/content/12/532/eaay8707.short

This topic was modified 1 year ago by dumbcritic

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Robert Hunter
(@roberthunter)
Joined: 1 year ago
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I am looking for an integrated .M.D. that would assist through some of these therapies? Hopefully between Santa Barbara and LA? Looking for starting point .. .thnx


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dumbcritic
(@dumbcritic)
Joined: 4 years ago
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Topic starter  

@roberthunter Hi Robert,

As I'm the other side of the pond I can't help, but there may be certain Facebook groups, such as this one which may be of some use to you https://www.facebook.com/groups/1083255155142750/

 


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Daniel
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Taulant Gashi
(@taulant-g)
Joined: 1 year ago
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@daniel Hi Daniel. My name is Taulant i am 24 years old living in Sweden. I have been diagnosed with last stage inflammatory myofibroblastic tumor (soft tissue sarcoma). I´ve read almost every post and i find many things interesting and that i think i could incorporate in my chemotherapy. Are there any repurposed drugs or other therapies that would be particularly interesting for me? I am going to use the Care Oncology Protocol alongside my chemotherapy(doxorubicin) which is every three weeks. I am thinking about I have read so much and feel optimistic but there are too many things to choose from and i feel slightly confused. Your help would mean so much. Thank you.

 


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Daniel
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@taulant-g

Dear Taulant,

I am so sorry to hear you have to deal with this at such an early age and home you will overcome this soon. I would like to first publish a post these days and after that I will come back to your question, answering with reference to that post. Thank you for your understanding. 

Kind regards,
Daniel

 


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Taulant Gashi
(@taulant-g)
Joined: 1 year ago
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@daniel yes of course, i will happily wait, thanks

 


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Daniel
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Posted by: @taulant-g

@daniel Hi Daniel. My name is Taulant i am 24 years old living in Sweden. I have been diagnosed with last stage inflammatory myofibroblastic tumor (soft tissue sarcoma). I´ve read almost every post and i find many things interesting and that i think i could incorporate in my chemotherapy. Are there any repurposed drugs or other therapies that would be particularly interesting for me? I am going to use the Care Oncology Protocol alongside my chemotherapy(doxorubicin) which is every three weeks. I am thinking about I have read so much and feel optimistic but there are too many things to choose from and i feel slightly confused. Your help would mean so much. Thank you.

 

Dear Taulant,

I think the following posts should be relevant:

1. https://www.cancertreatmentsresearch.com/if-chemotheraphy/

2. https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

3. https://www.cancertreatmentsresearch.com/drugs-and-supplements-that-block-fermentation-and-help-fight-cancer/

4. https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/

Of these, as a concept I would chose to address the following:

1. Reduce tumor resistance to chemo

Here I would specifically consider alkalizing methods prior to chemo as Doxo is a weak base as discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/ In order to achieve this I would consider either DCA or Natrium bicarbonate intravenous prior to chemo or Basentabs (alkalising tablets available online).

Using Verapamil or Ketokonazole to reduce MDR if possible https://www.cancertreatmentsresearch.com/if-chemotheraphy/

Using Doxy from COC protocol helps to address the intratumoral bacteria.

Using some options discussed here to increase the blood flow to the tumors https://www.cancertreatmentsresearch.com/if-chemotheraphy/ When using Niacin try it in advance as it may induce some flushing (just read about that on the web).

Inhibiting authophagy with Hydroxychloroquine could help - but maybe its difficult to find it now due to Corona

2. Increase ROS (which could also be part of the first but it's more suitable to address it separately)

See the discussion here https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/ I would at least use one of the following Sulfasalazine, Retinoic Acid, Auranofin

3. Reduce fermentation (known to be high in sarcomas)

Canagliflozin could be one to use here but if not available check for some strong ones on this list https://www.cancertreatmentsresearch.com/drugs-and-supplements-that-block-fermentation-and-help-fight-cancer/

4. Reduce inflammation

Olive Leaf Extract, Black Cumin Oil, Omega 3

5. Increase immune system and support organs

Mushrooms such as Coriolus, Reishi, Agaricus, D3, Melatonin 

Finally, when using COC, you may want too consider applying the concept discussed here https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer/ i.e., Metformin shoudl be stopped a few days before chemo and restarted during the day with chemo. That applies for all those drugs and supplements that are known to seriously slow down tumor cells - we need to stop them a few days prior to chemo.

I hope this helps and if you have specific questions, please let me know.

Kind regards,
Daniel

 


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Taulant Gashi
(@taulant-g)
Joined: 1 year ago
Posts: 4
 

@daniel Thank you, you are so kind! I have been also thinking about using 3-BP, Salinomycin, 2-DG and Phlorizin. Which ones would you prefere and which ones are best before or after chemo? Do you think these different therapies will interfere negatively with any of the drugs you suggested above or my chemo? How many days before chemotherapy should i stop DCA? 


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Daniel
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@taulant-g You are very welcome! Do you have access to these options?


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Taulant Gashi
(@taulant-g)
Joined: 1 year ago
Posts: 4
 

@daniel No, i will have to order them. The only things i have right now is the COC protocol, the supplements you suggested and Vit C IV. I will have my second course of chemo next tuesday, i want to get as many of the compounds as possible to increase the effect of the chemotherapy, since my oncologist have ordered 3 rounds of doxorubicin before i do a CT scan. 


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Daniel
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@taulant-g

Hi Taulant,

Please read more about each before considering the use and discuss with am medical trained person. 3-BP, Salinomycin, 2-DG and Phlorizin are all experimental and not yet drugs. It is possible to access them but it is not straightforward and it will take some efforts.

When you have the drugs and supplements aligned, just share your plan here and I and/or other helpful friends here will react on that.

Kind regards,
Daniel


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Zhang
(@zhang)
Joined: 1 year ago
Posts: 2
 

Hi all,

I am a 79 year old, in good health, with recurrent prostate cancer in my lymph nodes. I'm on hormone therapy and abiraterone, as well as the COC cocktail, dipyridamole and quite a few herbal anti-cancer medicines such as curcumin. I've tried IV Vit C on my own, but even then the cost amounts to a lot of money.  Recently, I read about Bio Active-C, which claims to be ten times more absorbable/bioavailable compared to ordinary Vitamin C. The L-ascorbate crystals have a sodium molecule attached in addition to some other factors which, they claim leads to a very high rate of absorption into the cells. They reported that the Riordan Clinic in Kansas feels reports that Bio Active-C can be absorbed at almost the level of IV Vit C. Their website is healing optimized.com.

My naturopath is skeptical. Do any of you have any experience with this product and its claims?

Thanks for your help.

 


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Daniel
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Dear @zhang,

Thank you for your message. I checked the Vitamin C you mentioned, and I think there is too much marketing behind and too little facts to support that. Otherwise, I would immediately consider contacting them and start a collaboration with MCS Formulas. Here is the research they share on this product on their website https://mk0healingoptimto1kb.kinstacdn.com/wp-content/uploads/2020/04/BioActive-C-Research.pdf In my view, this is by far not enough to support the claims, but there is more research that I haven't found yet on this one?

Next to the conventional options, here is relevant info consolidate on prostate:

- https://www.cancertreatmentsresearch.com/prostate-cancer/

- https://www.cancertreatmentsresearch.com/community/prostate-cancer/

If you are aware of any other new treatment options that you find very relevant against prostate cancer, please share.

Thank you and have a nice Sunday!

Kind regards,
Daniel 


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Zhang
(@zhang)
Joined: 1 year ago
Posts: 2
 

@daniel What an amazing site! The work you put into it is extraordinary, and the number of people contributing and benefiting it very impressive. I started on the alternative route through a naturopath; later I discovered Jane McLellen and, more recently, your site. 

I don't want to be too long, but I guess a little background might be helpful. 2015 rising PSA; attempted naturopathic treatments, without positive results. 2016 started hormone therapy. 2017 has pelvic radiation and brachytherapy. Hoped the cancer was gone, but summer of 2019 PSA started rising rapidly. PSMA pet scan indicated metastases into lymph nodes, cancer still hormone sensitive. Restarted hormone therapy and, in 2020, abiraterone/prednisone (5mg). In addition to these I'm taking, daily, Doxycycline (100mg), Metformin (1000mg), Atorvastatin (80mg), Mebendazole (200mg), Dipyridamole (200mg), green tea extract (2100mg), Quercetin (enzymatically modified isoquercitrin 150mg with 150mg vitamin C), berberine (1500mg), Loratidine (10mg), ursolic acid (375mg), HCA (1500mg), Vit E (150mg), Vitamin K2 (360mcg) with Vitamin D3 (3000IU), resveratrol (80mg), Omega 3 fish oil (1800mg), magnesium (400mg). I eat a healthy low-sugar, low-meat diet and am physically active. Although I have cancer, I am well  (though tired), but would like to be able to get rid of or control the cancer so that I can get off the debilitating hormone therapy.

I have bought some Bioactive-C and ordered some dipsticks which are used at the Riordan Clinic with IVC treatments to measure VC in the urine. According to their research (clearly better that Bio Active C), the level of VC in the plasma (based on HPLC) can be correlated approximately to the level of VC in the urine (see https://riordanclinic.org/wp-content/uploads/2020/10/Screening-for-Vitamin-C-in-the-Urine-is-it-clinically-significatn-2005-v20n04-p259.pdf). I want to use VC to aid the Doxycycline a la Michael Lisanti's research, which you have referred to. I also want to use it with low-dose Azithromycin (knowing that already taking Doxycycline may well diminish their effectiveness. 

You mentioned that high dose IVC works with a different mechanism than lower dose VC, but I haven't yet been able to find an explanation. I think it's on the IVC blog.

I am looking at the links in your reply above and may have questions later about those articles. I also know that you lean towards focusing strongly on one area rather than spreading treatment attempts out too much and would be interested in your feedback on my current approach.

All the best to you, I hope you have some time to relax.

Allan


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Daniel
(@daniel)
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Thanks a lot Allan!

Indeed, teh explanation about Vit C is in the post I wrote some years ago on Vitamin C. Even if I wrote posts a longer time ago, I update them from time to time.

If you like to focus on the Lisanti like approach, you will want to read this post that is focused on improving such a strategy https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer-a-strategy-to-fight-cancer/

Another strategy relevant to hormonal cancers is this one https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ that is good to be aware of. There is a good overlap between the elements discussed and the supplements and drugs you are using.

Other that should be very relevant in prostate c should be Reishi, Artemisin, Genistein, SDG from Flaxseed. 

Here is also a nice and relevant report from Don https://www.cancertreatmentsresearch.com/update-from-don-on-the-healing-from-prostate-cancer/ he succeeded to manage without hormonal therapy for long time. As I know, now he is on hormonal therapy having a nice and relaxed life in Hawaii. 

Kind regards,

Daniel


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