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help with dosis and interactions supplements with chemo and immuno.

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JoanP
(@joanp)
Joined: 1 month ago
Posts: 2
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Hello everyone, I would like to have advice on how the following supplements would work that I already have, but we have waited to apply them to know the exact treatment of my father's cancer, especially to learn about possible interactions..

My 71-year-old dad has:

-Throat cancer: Squamous keratinizing carcinoma, moderately differentiated.
PD-L1 22C3 TPS 1-2%

now lung stains have been discovered and after biopsy:

-lung cancer: mucinous adenocarcinoma.
PD-L1 22c3: Negative
EGFR: Not mutated
ALK: Negative /Wild Type
ROS1: Negative /Wild Type

The treatment they have given is:

*immunotherapy: PEMBROLIZUMAB (KEYTRUDA)
*chemotherapy: PEMETREDEX
*chemotherapy: CARBOPLATIN

all via intravenous scheduled every 3 weeks.

He is currently taking continuously:

Mycotherapy: Myco-PNE 1 dose every 12 hours ( https://hifasdaterra.com/product/mico-pne/)

and now we're going to add all this, and that's where my questions come from.

*Boswellia MEGA AKBA 2 capsules to 4 capsules per day.    not sure if prior to food or with food???
Berberine - 2 to 3 capsules per day - prior to food 
Honokiol - 2 to 4 capsule per day - prior to food 
Vitamin C - as much as possible  - prior to food 
Omega 3 - 3 capsuler per day - prior to food 
*Curcumin C3 - 8 capsules per day -- What dose would you start with and how would you increase it to reach 8 grams?
Milk Thistle - 2 capsules per day to support the liver
Artemisinin - min 2 capsules per day (5 days ON and 2 days OFF)

I would like to know if any of the above can negatively interfere with the type of chemo and immuno that is being applied to my father...

And another very important question, of the supplements mentioned:

which supplements do not need to be cut on the day of the chemo/immuno?

and which ones to stop giving during the day of chemo/immuno , that is, how many days before should it stop and how many days after the dose of chemo/inmuno could it start?

 

I appreciate any help regarding what you would do in your case.
I am very lost regarding the questions asked and I really need help..
Thank you very much friends, greetings from Spain

 

Juan.


   
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johan
(@j)
Joined: 4 years ago
Posts: 1157
 

Hi @joanp, I don't think the supplements you mention could negatively impact the effectiveness of chemo. N-acetylcysteine and glutathione are best avoided during active chemotherapy. My own preference is to not use artemisinin and high-dose vitamin c together but that's very debatable. Magnolol could be a good addition to your supplement regimen. Suerte!

 


   
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JoanP
(@joanp)
Joined: 1 month ago
Posts: 2
Topic starter  

I forgot to mention that all supplements are MCS except mushrooms.


   
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johan
(@j)
Joined: 4 years ago
Posts: 1157
 
Posted by: @joanp

I forgot to mention that all supplements are MCS except mushrooms.

That's great, the quality of a supplement is an important factor that is often overlooked. The supplements you mention are good choices in my opinion. Curcumin, Berberine, and Honokiol can sensitize cancer cells and make platinum chemotherapy agents more effective. On top, they add other anticancer effects and can reduce the side effects of chemo i.e. protect the liver etc. On my blog, I've listed many supplements and combinations of supplements and repurposed drugs that can be useful additions to standard treatment: https://synergiesforcancertreatments.blogspot.com/


   
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Daniel
(@daniel)
Admin
Joined: 7 years ago
Posts: 1147
 
Posted by: @joanp

Hello everyone, I would like to have advice on how the following supplements would work that I already have, but we have waited to apply them to know the exact treatment of my father's cancer, especially to learn about possible interactions..

My 71-year-old dad has:

-Throat cancer: Squamous keratinizing carcinoma, moderately differentiated.
PD-L1 22C3 TPS 1-2%

now lung stains have been discovered and after biopsy:

-lung cancer: mucinous adenocarcinoma.
PD-L1 22c3: Negative
EGFR: Not mutated
ALK: Negative /Wild Type
ROS1: Negative /Wild Type

The treatment they have given is:

*immunotherapy: PEMBROLIZUMAB (KEYTRUDA)
*chemotherapy: PEMETREDEX
*chemotherapy: CARBOPLATIN

all via intravenous scheduled every 3 weeks.

He is currently taking continuously:

Mycotherapy: Myco-PNE 1 dose every 12 hours ( https://hifasdaterra.com/product/mico-pne/)

and now we're going to add all this, and that's where my questions come from.

*Boswellia MEGA AKBA 2 capsules to 4 capsules per day.    not sure if prior to food or with food???
Berberine - 2 to 3 capsules per day - prior to food 
Honokiol - 2 to 4 capsule per day - prior to food 
Vitamin C - as much as possible  - prior to food 
Omega 3 - 3 capsuler per day - prior to food 
*Curcumin C3 - 8 capsules per day -- What dose would you start with and how would you increase it to reach 8 grams?
Milk Thistle - 2 capsules per day to support the liver
Artemisinin - min 2 capsules per day (5 days ON and 2 days OFF)

I would like to know if any of the above can negatively interfere with the type of chemo and immuno that is being applied to my father...

And another very important question, of the supplements mentioned:

which supplements do not need to be cut on the day of the chemo/immuno?

and which ones to stop giving during the day of chemo/immuno , that is, how many days before should it stop and how many days after the dose of chemo/inmuno could it start?

 

I appreciate any help regarding what you would do in your case.
I am very lost regarding the questions asked and I really need help..
Thank you very much friends, greetings from Spain

 

Juan.

Dear Juan,

Thank you for your question. While I appreciate you are using MCS Formulas supplements, I will not discuss anything in relation to that but try to address your question:

1. Chemo used has at least one prooxidant component that is used to fight cancer cells. So we will need to keep that in mind. Otherwise, I do not see anything that woudl interfere with that as long as they are implemented in the right way.

2. By the right way, I mean we need to keep in mind two aspects:
- is a supplement or drug (in case you are also using that) glycolisis inhibitor or not
- is a supplement antioxidant or pro-oxidant - I already discussed in other places on this website that I see 3 categories of supplements: super anti-oxidants (e.g. NAC, ALA, etc.), antioxidants that act as pro-oxidants at the level of cancer cells, and pro-oxidants

3. Having the above in mind, I woudl consider the implementation of those on the list in the following way:

Boswellia MEGA AKBA - taken on empty stomach - I woudl stop two days before chemo and restart two days after chemo
Berberine - I would stop two days before chemo, and restart immediately after chemo or as soon as possible
Honokiol - I woudl stop two days before chemo and restart two days after chemo
Vitamin C - I woudl stop two days before chemo and restart two days after chemo
Omega 3 - I woudl take it continuously though Chemo
Curcumin C3 - I woudl stop two days before chemo and restart two days after chemo - I woudl start with 1-2 grams per day, after several days (if it is tolerated well) I woudl make a step from 25% of the target daily dose to 50%, after another several days I woudl move to 75% of the target dose and finally, after several days I would move to 100% target daily dose. Note: high dose Curcumin may lower blood pressure so I woudl keep an eye on that. If the patient takes blood thinners, I woudl also be careful since Curc also has impact on that.
Artemisinin - - I woudl take it continuously though Chemo but keeping the 5 days ON and 2 days OFF strategy
 
I hope this helps.

Kind regards,
Daniel


   
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