Diphencyprone and other Skin Sensitizers  

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Jcancom
(@jcancom)
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Joined: 2 years ago
Posts: 129
06/05/2018 5:44 pm  

Diphencyprone can induce an allergic skin reaction that can help treat melanoma. It is quite impressive that up to 80% response rates. Many of these reports were in the context of local topical treatment, though the report below describes a patient with metastatic illness responding after silver sulfadiazine was added.

https://www.jaad.org/article/S0190-9622(10)00684-5/fulltext


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Jcancom
(@jcancom)
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Joined: 2 years ago
Posts: 129
06/05/2018 5:48 pm  

Does anyone know of a reference that would have a near complete listing of cancer treatments listed? We have stumbled upon quite a few cancer treatments (such as beer etc.) as a result of merely randomly surfing the net. There has to be a more organized and systematic search strategy. Is there a reference somewhere?


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Daniel
(@daniel)
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06/05/2018 7:45 pm  

J, very nice to hear from you. The link you shared is really interesting. I was not aware about the potential behind "silver sulfadiazine". This case report is very relevant so would be helpful for others if you would add this also in the section "Skin cancer".

Unfortunately, there is no such list that I am aware, to uncover the true valuable findings. The information is usually very fragmented and usually focused on the popular approaches. There are many hidden gemstones like the one you shared here, and I think we need to do the work to uncover them, and create that list. 


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Jcancom
(@jcancom)
New Member
Joined: 2 years ago
Posts: 129
06/05/2018 10:44 pm  

With the diphencyprone, it does induce eczema, so the treatment with be at least mildly uncomfortable.

Yes, I was thinking along the same lines to also post to the skin cancer thread. I certainly think that we should try to think up ways of letting the information to flow to the people that need it. Likely the biggest problem typical cancer patients face is being completely overwhelmed by the sheer mass of information available. There are so many treatments out there and paralysis through analysis often does occur. For many trying more treatments probably would be helpful.

D, immunotherapy of melanoma is becoming very interesting! About 10 years ago research came out in mice with the combo: monobenzone, imiquimod, and CpG (MIC). This resulted in long term survival in 85% of melanoma mice. Monobenzone and imiquimod are creams that can be applied topically while the CpG is an injection. 

A phase II study was published in January in which they treated patients with Monobenzone and imquimod. 11 of 21 had some response. Adding in the CpG might greatly enhance the response. The CpG is a TLR9 agonist and many of them are in development. D, are you aware of availability of CpG?

CPG-7909 (PF-3512676, ProMune), CpG 2006 ODN (also known as CpG ODN 7909)     It seems to have underwent a large amount of clinical testing, though I am not sure whether it is actually available.

D, this is very exciting research! Putting this all together should give a highly effective treatment for melanoma! So, we have monobenzone, imquimod, CpG/TLR9, possibly HSP70, anti-CD4 antibodies to knock down the TREGs, also perhaps NEKTR214/IL-2 

https://www.ncbi.nlm.nih.gov/pubmed/29628419

https://www.ncbi.nlm.nih.gov/pubmed/20498710

https://www.ncbi.nlm.nih.gov/pubmed/29632737

https://www.ncbi.nlm.nih.gov/pubmed/29602773


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