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Anti-inflammatory drugs

Joined: 5 years ago
Posts: 104
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From the abstract: ''Here, we show that therapeutically targeting the COX-2/PGE2/EP2-4 pathway with widely used non-steroidal and steroidal anti-inflammatory drugs synergized with ICB (immune checkpoint blockade) in mouse cancer models.''
The authors of the paper cite retrospective studies which suggest that NSAIDs may enhance progression-free survival and/or overall survival of patients receiving ICB
Also, addition studies, which showed that the overall response rate (tumour shrinkage) of patients who discontinued ICB and received corticosteroids was similar, and in some cases even higher, than that of patients maintained on ICB

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