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Alpha-Gal-Cer Immunotherapy


Jcancom
(@jcancom)
Joined: 5 years ago
Posts: 553
Topic starter  

Very startling!

About 30 years ago Japanese researchers found that the Okinawan marine sponge Agelas mauritianus had a potent immunochemical that they refined and enhanced to yield KRN7000. This chemical induces a strong cytokine release by Natural Killer T Cells (NKT cells). A new form of this molecule alpha-c-galactosyceramide has been found to be up to 100 times more potent.

Below web site also mentions another form in development 7DW8-5. When this was combined with the vaccine adjuvant MPLA an anti-cancer effect was seen. PMID:27132023

It is frustrating though after all of these decades of research none of these products are available to patients. Yet, the potential for this class of chemicals is BIG. It could be used in vaccines, diabetes, cancer...

http://www.alpha-galcer.net/cancertype.html


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dumbcritic
(@dumbcritic)
Joined: 5 years ago
Posts: 104
 

Back in Sept dosing got underway in the second stage of a PhI/IIa trial evaluating BioLineRx's AGI-134 in patients with solid tumors. Preliminary data should be available by year-end 2020.

AGI-134 is a synthetic alpha-Gal immunotherapy designed to be injected directly into a tumour, harnesses the body's anti-Gal antibodies to induce a systemic, antitumour response to the patient's own neoantigens.

Here is a link to the trial https://clinicaltrials.gov/ct2/show/NCT03593226


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dumbcritic
(@dumbcritic)
Joined: 5 years ago
Posts: 104
 

Some preclinical data https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-1059-8


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