New Strategy for Head and Neck Squamous Cell Carcinoma Treatment via Immune Regulation
Topic starter 04/06/2022 2:41 pm
Factors that May Balance the Immune System (Lower Th2)
- Sun/UVB light  – UVB decreases IFNy in Th1 dominance but increases it in Th2 dominance. So it’s balancing. It also decreases IgE responses. UVA in the sun also decreases Th2 dominance .
- Probiotics… Decreases Th2: L Reuteri  (probiotic), L. Plantarum  (probiotic), L. salivarius  (probiotic), L. lactis  (probiotic)… Increases Th1: S Boulardii? , L. Sporogenes, L Acidophilus , L casei , Lactobacillus rhamnosus GG , Lactobacillus paracasei , Lactobacillus salivarius , B Longum , L Brevis , L fermentum .
- NAC/Glutathione sufficiency decreases Th2  and increases Th1 .
- Licorice -18/β-glycyrrhetinic acid+LicoA [15, 16]. Glycyrrhizin increases IFNy and decreases the Th2 response [17, 18].
- Gynostemma . This is a Th1 immune stimulant and reduces allergies. Gynostemma is recommended also because it’s a powerful mitochondrial enhancer.
- Ginger or juice the root [20, 21]. Recommended because it has anecdotal support in addition to the research, but also because you can get it everywhere, it has a long history of use and for its multitude of other benefits.
- Reishi 
- Tinospora . This has a clinical trial backing it, with some anecdotal support.
- Quercetin 
- Astragalus  Decreases Th2 and increases Th1.
- High-intensity exercise 
- Cold exposure (Antarctic winter) 
- Oxytocin (decreases IL-4) Falling in love, having sex, nursing, and positive social encounters increase oxytocin . L Reuteri is also being researched for increasing oxytocin 
- LLLT 
- Inhibiting mTOR.
- Kiwi 
- Black rice 
- Rice 
- Rice Bran Oil 
- Cocoa 
- Black Cumin Seed Oil 
- Coffee (in moderation) 
- Bee products: Royal Jelly , Bee Pollen  Propolis, YS Royal Jelly/Honey (may increase Th1 and TNF-alpha) [43, 44]
- Black pepper 
- Prebiotics , FOS and GOS (prebiotics) 
- Adequate intake of vitamin B(6), folate, B(12), C, E, and of selenium, zinc, copper, and iron . These may also support healthy immune defense.
- Vitamin A/Retinol  (IL-4, IL-13)
- Genistein [50, 51]
- Chondroitin sulfate 
- Spirulina  – without increasing Th1
- Oregano oil/Carvacrol 
- Theanine  – decreases a th2 type immune response
- Luteolin 
- Resveratrol 
- Theaflavins  (found in black tea)
- Apple polyphenols 
- Lycopene  (in tomatoes)
- Lutein 
- Fenugreek 
- Baicalin/Chinese Skullcap 
- Rutin 
- Fisetin [65, 66]
- Ashwagandha 
- Ginseng (Asian)  – Seen as mostly stimulating but also regulating. Being researched for affecting TNF-α, IL-1β, IL-6, and IFN-γ (produced by macrophages) and raising IL-2, IFN-γ, IL-1α, and GMC-SF (produced by sleep cells).
- Grape Seed Extract [69, 70], but animal studies point to decreased Th1 cells in certain experimental conditions like Rheumatoid Arthritis 
- Red Wine Polyphenols 
- The following are thought to increase Th1: Colostrum , Bilberry , Icariin , and Lion’s Mane
- Andrographis 
- Beta Glucans  – found in mushrooms and being investigated for inhibiting TNF .
- Schisandra , Deer Antler Velvet , Chrysin , Burdock root , Cordyceps , Ecklonia cava , Butterbur, Bamboo extract 
- Gallic acid 
- Kaempferol 
- Caffeic acid (found in coffee, green coffee extract, apples, artichoke, berries, and pears, wine) [88, 89]
- Curcumin  – contradictory 
- Epigenetics: mir-27b , mir-128 , mir-135b , mir-155 , mir-340 
The following might lower Th2 but should be avoided because of numerous detrimental health effects: Nicotine , Choline deficiency , and Zinc deficiency .