Head and neck Squam...
 

Head and neck Squamous Cell Carcinoma  

Page 1 / 2
  RSS

Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
28/12/2019 3:49 pm  

Hi,
I'm French, and I'm here for my father (55) who has squamous cell carcinoma under the soft palate (HPV-). He had radiotherapy, then a recurrence therefore an operation. The operation was not enough, and he has lumps in his neck. He therefore did a chemo (4 courses) of Carboplatin, Taxol, Cetuximab.
The biggest problem for my father is that his nodules in the neck block the lymphatic drainage, and since his operation, he has a very significant edema in the face, which is very annoying. The chemo made the nodules decrease, and his edema could decrease. But after 4 courses, the chemo was no longer effective. He tried Nivolumab immunotherapy, which got worse in two weeks: many visible nodules in the neck returned.
He started chemotherapy with Methotrexate a month ago but today the oncologist has decided to stop, the edema not improving. And he doesn't offer anything anymore.
So I'm desperately looking for a way to help him, because his edema is too unbearable (he closes his eyes), he can't stay like that. And for that, I have to find a way to reduce the nodules in the neck.
We also had results of genetic mutations yesterday:
Genomic Alterations Identified :
GENE    /   ALTERATION
CDKN2A    loss
CDKN2B    loss
FBXW7    S546fs*3
MTAP    loss
NOTCH1    V1575L
TERT    promoter -124C>T
TP53    G279E
If anyone has any advice, we are takers, we have nothing more to lose...
Thank you all for sharing your advice on this forum,
Anaelle


Quote
Topic Tags
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
28/12/2019 5:43 pm  

@anaelle34

Dear Anaelle,

I am so sorry to hear about these difficulties ... 🙁

1. To reduce the inflammatory reaction triggered by drugs such as Nivolumab, it has been suggested in literature to use angio-genesis inhibitors such as but not limited to those discussed here https://www.cancertreatmentsresearch.com/category/angiogenesis-inhibitors/ Of these some of the most powerful I discussed are Thalidomide, Taurolidine and TM. Thalidomide and Taurolidine can act faster while TM requires several months until the conditions required for it's actions are met. Taurolidine can be accessed at several clinics in Germany. Celecoxib could also help on this line and it is easier to access.

2. Many of the treatments discussed on this website but I realise that you need to use something fast, easy to access and implement, that offers real chances. Silver solution is one of the easiest to access and implement https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/

3. Another option that I would seriously consider and it is easy to implement, is to mix various substances with anti cancer effect in DMSO, and applied topically on one of the lymph nodes. Here is how I combined 3BP with DMSO for my wife obtaining a solution that we could apply on the tumors https://www.cancertreatmentsresearch.com/3-bromopyruvate/  
Other drugs such as DCA could also be mixed with DMOS.
I would always test on one tumor only and observe the reaction.

4. A more advanced option, but probably would take time to access is to move along the intravenous treatments line and try to combine options such as 2DG, Vit C, Curcumin intravenous and others, with repurposed drugs. For this, you could consider going to a cancer clinic in Europe. If this is an option for you please let em know and I will recommend a clinic that is both good and very accessible.

Please let me know if I can help with anything else.

Kind regards,
Daniel

 


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
28/12/2019 8:23 pm  
Posted by: @anaelle34

Hi,
I'm French, and I'm here for my father (55) who has squamous cell carcinoma under the soft palate (HPV-). He had radiotherapy, then a recurrence therefore an operation. The operation was not enough, and he has lumps in his neck. He therefore did a chemo (4 courses) of Carboplatin, Taxol, Cetuximab.
The biggest problem for my father is that his nodules in the neck block the lymphatic drainage, and since his operation, he has a very significant edema in the face, which is very annoying. The chemo made the nodules decrease, and his edema could decrease. But after 4 courses, the chemo was no longer effective. He tried Nivolumab immunotherapy, which got worse in two weeks: many visible nodules in the neck returned.
He started chemotherapy with Methotrexate a month ago but today the oncologist has decided to stop, the edema not improving. And he doesn't offer anything anymore.
So I'm desperately looking for a way to help him, because his edema is too unbearable (he closes his eyes), he can't stay like that. And for that, I have to find a way to reduce the nodules in the neck.
We also had results of genetic mutations yesterday:
Genomic Alterations Identified :
GENE    /   ALTERATION
CDKN2A    loss
CDKN2B    loss
FBXW7    S546fs*3
MTAP    loss
NOTCH1    V1575L
TERT    promoter -124C>T
TP53    G279E
If anyone has any advice, we are takers, we have nothing more to lose...
Thank you all for sharing your advice on this forum,
Anaelle

Hi Anaelle,

I'm very sorry to hear this. Daniel mentioned silver nanoparticles, and HDAC inhibition could provide additive effects.

HDAC inhibitors have anti-cancer and anti-inflammatory properties:

"Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade
of the EGFR-Arf1 axis"
Study: https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1080-8
"studies revealed the activity of Arf1 was much higher in metastatic HNSCC cells than cells derived from the primary sites, and HDAC inhibitors
induced protein degradation of epidermal growth factor receptor (EGFR), which consequently suppressed Arf1 activation in HNSCC cells."

HDAC inhibitors as anti-inflammatory agents
"they may prove useful particularly in situations where current anti-inflammatory therapies are suboptimal."
Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2013887/

HDAC inhibitors: valproic acid, phenylbutyrate

HDAC inhibition in combination with silver nanoparticles:

https://www.ncbi.nlm.nih.gov/pubmed/30111752
https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/

Best Regards,

Johan


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
28/12/2019 10:16 pm  

@daniel

Thank you for responding so quickly, and thank you for these ideas! First of all, I think I opt for the Silver Solution which will be the easiest and quickest to do. Sales in France are intended only for use on the skin. Do you think he can use this product for example, orally?
https://www.onatera.com/produit-argent-colloidal-10ppm-1l-bio-colloidal,6877.html?version=2
Monday we see another oncologist who may decide to give him methotrexate chemotherapy again. Do you think it may be useful to add lansoprazole to increase the effectiveness of chemo?
Thanks again
Anaelle


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
28/12/2019 11:08 pm  

@anaelle34

You are very welcome! Yes, they sell only for use on the skin - they are not allowed to suggest oral administration. I just bought in the Netherlands one like this and used orally for an infection.

If I would want to start with Silver solution, I would buy one commercially available to be able to start fast, but at the same time I would prepare myself to be able to make it at home in the same way as the patient who cured himself made it at home. Following his procedure its best since he was successful. And the procedure is very simple.

Adding lansoprasole to Methotrexate may not help since Meth seems to be a weak acid.

If you have a doctor willing to help, I can connect him with the US academic team to support with implementation of intravenous metronomic 2DG after Meth as discussed here https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/

Kind regards,
Daniel


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
29/12/2019 12:51 am  

@johan

Thank you very much for these details! I will read this carefully! 


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
29/12/2019 1:05 am  

@daniel

Ok this is what I will do for the silver solution !

For methotrexate, during the first 2 injections he had, the chemo seemed more effective than the next two. And the only difference was that he had lansoprazole for the first two... That's why I'm wondering. I looked on the site "Drugbank", and I read that it is written: "The serum concentration of Methotrexate can be increased when it is combined with Lansoprazole".
So I thought it might be an explanation? I don't really understand "weak acid" ... 

At the moment we don't have a doctor open-minded enough to help us ... I will tell you if this evolves

Thank you very much

Anaelle


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
29/12/2019 6:34 pm  
Posted by: @anaelle34

@johan

Thank you very much for these details! I will read this carefully! 

@anaelle34

HDAC inhibition is important in gene regulation, but success in the use of HDACi seems dependant on adjunct treatments. Combined treatments with PKC inhibitors appears to be a good addition:

"To improve the HDACi therapy against tumorigenesis and deadly metastasis, we suppressed the HDACi-enhanced cell migration and metastasis by combined treatments with PKC inhibitors; either dietary supplement curcumin or U.S. Food and Drug Administration–approved tamoxifen leaded to identification of new mechanism-based low toxic modalities for potential long-term treatment of solid tumors" (Ref)

Inhibition of Protein Kinase C by Tamoxifen

In this study: "Tamoxifen inhibited the proliferation of the skin squamous cell carcinoma (SCC) cell lines A431, DJM‑1 and HSC‑1. A431 cells did not express ER‑α or -β, suggesting that tamoxifen may exert antiproliferative effects on skin SCC cells via a non‑ER‑mediated pathway. Tamoxifen increased the intracellular calcium concentration of skin SCC cells, and this increase in intracellular calcium concentration by calcium ionophore A23187 suppressed the proliferation of skin SCC cells. These data indicate that tamoxifen inhibited the proliferation of human skin SCC cells via increasing intracellular calcium concentration."

And, in this study " Tamoxifen inhibits the growth of head and neck cancer cells and sensitizes these cells to cisplatin induced-apoptosis: role of TGF-beta1."

 

 


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
29/12/2019 8:03 pm  

@anaelle34

Hi Anaelle,

Regarding Lansoprazole, there are two different ways it can affect Methotrexate:
- first Lansoprasole decreases Methotrexate clearance, leading to elevated blood levels of methotrexate. This could lead to both higher effectiveness against the tumor but also possibly higher toxicity
- second, Lansoprazole may lower the capability of tumor cells to export protons (acidity) in the extracellular space. This helps when the chemo is of weak-base type but may not help when the chemo is of weak-acid type as discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

If you felt that Lansoprazole actually helped, it could be a good idea to use it again and see if that is indeed the case.

Kind regards,
Daniel


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 12:45 pm  

@johan

Thank you very much for these articles! Unfortunately, the oncologist does nothing to help us, and I don't know how we can get Tamoxifene... 


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 12:53 pm  

@daniel

Thanks a lot for your help. All this is complicated for me who is new! I didn't even know if Methotrexate is chemo weak base or weak acid.
I was wondering about one last thing, for the Silver solution, there are no contraindications with high doses of cortisone?
And my father feeds by gastric tube because it cannot swallow with edema. So can I pass the Silver solution through the gastric tube? I imagine it would have been better by mouth...
Thanks again


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
30/12/2019 2:07 pm  
Posted by: @anaelle34

@johan

Thank you very much for these articles! Unfortunately, the oncologist does nothing to help us, and I don't know how we can get Tamoxifene... 

@anaelle34

We experienced a similar situation, my father-in-law´s neurooncologist said no further treatment was possible, and we found another who would. I know it´s a very tough situation, I´m very sorry.

You can buy Tamoxifen  https://www.buy-pharma.md/Products/search?keyword=tamoxifen online. 

Best,

Johan

 


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 5:38 pm  

@johan

Is it possible to buy on this site ?! Because I see that there is chemo that they stopped him! We've been fighting for 2 weeks so that they give it back! And I see that we could buy it ourselves? Really? If so, it’s amazing! 

(Sorry for my bad english ...)


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 5:50 pm  

@johan

And why is it so cheap? We are often told that chemos are very expensive...

Thanks for this precious adress !!


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
30/12/2019 5:51 pm  

@anaelle34

yes you should be able to buy anything available on that online pharmacy


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
30/12/2019 5:58 pm  

Inhibitor of autophagy

In vitro and in vivo antitumor effects of chloroquine on oral squamous cell carcinoma:

https://www.ncbi.nlm.nih.gov/pubmed/28849182


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 6:30 pm  

@johan

Unfortunately Buy Pharma tells me that they no longer deliver to France due to strict customs regulations... 

Thanks for this other idea with chloroquine!


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
30/12/2019 8:55 pm  

@anaelle34

Dear Anaelle,

If there is chemo that you know/expect that it helps your dad and cannot access in your country, you can always consider going to another country and try to receive it at a private clinic. Germany or Romania are for example countries where that may be possible.

Regarding your question, I am not aware of any interaction between silver solution and cortisone. I also do not think there is any issue when the solution is given by gastric tube.

Kind regards,
Daniel


ReplyQuote
Anaelle34
(@anaelle34)
New Member
Joined: 4 weeks ago
Posts: 15
30/12/2019 11:31 pm  

@daniel

@johan

Thanks a lot for your answers. Finally another oncologist has just agreed to give him back the chemo which relieved him a little, he has the injection tomorrow morning! It is weakly dosed, but I hope that by combining it with all your advice, we will obtain some results.
Thanks again to both of you


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
30/12/2019 11:37 pm  

@anaelle34

Dear Anaelle,

Great! When you have you plan (on what chemo is given and what supplements you intend to add), just share it here and we will try to give you our feedback.

Kind regards,
Daniel


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
30/12/2019 11:50 pm  

@anaelle34

that's good news! Hopefully, his new oncologist is more open-minded, at the very least he or she should carefully consider the alternative options(and studies) you're presenting considering the standard protocol has failed to provide any benefit for your father. Good luck!


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 10:31 pm  

@anaelle34

Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model.

https://www.ncbi.nlm.nih.gov/pubmed/18805045

Sulforaphane is also an HDAC inhibitor.

The best source for Sulforaphane is broccoli sprouts. A therapeutic dose approx 6o grams of the sprouts. It's a lot to eat but easier to ingest in a smoothy. Or a combination of sprouts with supplements and/or powder:

- Organic Broccoli Sprout Powder (Health Ranger)

- Avmacol®

- NanoPSA (a blend of NanoStilbene™ and Broccoli Sprout Extract)

 

 

 


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 10:59 pm  

I've attached fotos I took from a book on how to grow microgreens e.g broccoli sprouts (Growing Microgreens Step by Step by Susan Alima Friar).

PS It looks like I can only attach one file at a time so I'll split this into several posts 


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:01 pm  

how to grow microgreens e.g broccoli sprouts (part 2/6)


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:03 pm  

how to grow microgreens e.g broccoli sprouts (part 3/6)


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:04 pm  

how to grow microgreens e.g broccoli sprouts (part 4/6)


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:04 pm  

how to grow microgreens e.g broccoli sprouts (part 5/6)


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:04 pm  

how to grow microgreens e.g broccoli sprouts (part 6/6)


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 4 years ago
Posts: 578
02/01/2020 11:26 pm  

@johan

Hi Johan,

Very nice book and very nice glass boll 🙂 

Kind regards,
Daniel


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 1 year ago
Posts: 242
02/01/2020 11:32 pm  

@daniel

thanks, D! That's a millefiori paperweight. 

Btw, taking some selenium (either through food or supplement preferably yeast bound selenium or sodium selenite) along with sulforaphane could provide synergistic benefits. (ref)


Daniel liked
ReplyQuote
Page 1 / 2
Share: