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Calculator for dose conversion from animal models to humans

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(@aml)
Joined: 2 years ago
Posts: 124
Topic starter  

DoseCal: a virtual calculator for dosage conversion between human and different animal species

Context: The scientists as well as pharmacologists frequently convert the dose of drugs or extracts between human and different animal species. According to the literature, the extrapolation of the dose by simple conversion based only on body weight is not an accurate method. The miscalculation of dosage conversion may result in adverse effects due to overdose or reduced potency due to underdose.

Aim: To develop a conversion calculator with factual factor like Km factor.

Method: The virtual calculator was developed as a web-based application using hypertext pre-processor programming language. My SQL software was used to store the data related to DoseCal.

Results: Based on the Km factor, dose conversion calculator called DoseCal was developed. The DoseCal would provide the dosage for both per kg and actual weight of the animal taken for the experiment.

Conclusion: The DoseCal would assist scientists in the dosage conversion easily and accurately between species.

https://pubmed.ncbi.nlm.nih.gov/31746232

https://dosecal.cftri.res.in/index.php


   
Daniel, johan, Daniel and 1 people reacted
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(@j)
Joined: 6 years ago
Posts: 2136
 

that's a very useful tool!


   
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(@lepusreg)
Joined: 1 year ago
Posts: 1
 

Hmm. I have liquid suspension. According to that calculator, I'd have to take 41.6 ml !!! That sounds wrong. Looking for dosing for 10% liquid suspension panacur for livestock conv for human. This suspension is 100 mg fenben per 1 ml liquid. Livestock dose is 2.5 ml per 50 kg except for certain horse ascarids where its double that dose.  I'm looking for dose for general deworming and also cancer treatment dosing (in case they are different). 

Thanks!


   
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(@debbie-c-moore)
Joined: 10 months ago
Posts: 1
 

I need to know how much and how often to take Fenbendazole I weigh 173lbs. I have Ovarian cancer and I was told they can no longer help me


   
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(@christopher)
Joined: 9 months ago
Posts: 1
 

@debbie-c-moore Did you ever get an answer to this? I am also curious on dosage


   
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(@gojek88)
Joined: 8 months ago
Posts: 1
 

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(@jimboo)
Joined: 7 months ago
Posts: 1
 

I was diagnosed with Idiopathic pulmonary fibrosis (IPF) in March of this year. I read about Joe Tippin and his cancer treatment with Fenbendazole. I have purchased Panacurc (Fenbendazole) along with Berberine, Theracurmin, and Vitamin E. I know Tippin took these drugs for 3 days and then took the next 4 days off. My question is how long in all did he continue to take the drugs this way?


   
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(@j)
Joined: 6 years ago
Posts: 2136
 

@jimboo I don't know how long he took fenbendazole, but Joe's "all clear" PET scan was only 3 months after a PET scan "that lit up like a Christmas tree"

https://mycancerstory.rocks/the-blog/

Note that at the same time, he was taking Keytruda.

In an update he notes that he has eliminated vitamin E from his protocol.

If you decide to take Fenben and don't see any results within 3 or 4 months my guess is it's not working.


   
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