@jcancom We could start with Salinomycin 😀 which is an antibiotic
Talking about antibiotics....in this study adriamycin and lioposomal HK show synergistic antitumor effects.
we need an option to edit posts ?
Highly Water-Soluble Solid Dispersions of Honokiol : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920775/
@johan Honokiol, still, has a relatively good bio-availability and crosses brain blood barrier. But scientists are looking for ways to further improve its bio-availability.
We have the edit option, 5 minutes after the post was published. After that, if its something annoying, please let me know and I will help with editing.
Kind regards,
Daniel
Johan, it is so difficult to watch all of the research into metabolic treatments languish for years and years or realize that there were co-treatments lurking in plain sight that went unfound. When pharmaceutical companies advance a product through clinical trials, they typically would have spent years finding the best possible chemical, formulation etc. . Yet, with the treatments that we follow much of the research never seems to move forward. For example, research has found that 5-formylhonokiol is a more powerful form of honokiol, though we continue with honokiol. D notes that there is new evidence that magnesium can help with vitamin C. So much knowledge is beyond our awareness and it only emerges over the long term. If only we could integrate all of the knowledge, then very powerful treatments could emerge.
We have the edit option, 5 minutes after the post was published. After that, if its something annoying, please let me know and I will help with editing.
Kind regards,
Daniel
I had no idea, J's typo revealed the need for this feature...my visits to hahnemann will never be the same now.
Conversation is shifting around, though it is nice to see the vitality! Nebulizers? There has not been that much said on the forum about them. How helpful might this route of administration be with honokiol? Nebulizing could be an especially useful route for those with lung tumors, is this approach widely used?
D when I post there is no edit button showing immediately afterwards. There does not appear to be an option to edit posts.
Conversation is shifting around, though it is nice to see the vitality! Nebulizers? There has not been that much said on the forum about them. How helpful might this route of administration be with honokiol? Nebulizing could be an especially useful route for those with lung tumors, is this approach widely used?
and transdermal: http://www.yydbzz.com/EN/10.3870/j.issn.1004-0781.2018.06.003
Johan, it is so difficult to watch all of the research into metabolic treatments languish for years and years or realize that there were co-treatments lurking in plain sight that went unfound. When pharmaceutical companies advance a product through clinical trials, they typically would have spent years finding the best possible chemical, formulation etc. . Yet, with the treatments that we follow much of the research never seems to move forward.
J, I find it frustrating, there seems to be absolute lack of a sense of urgency.
D when I post there is no edit button showing immediately afterwards. There does not appear to be an option to edit posts.
J, we now have that option, Daniel must have enabled it just now as I was able to edit my last post.
I think solutol HS15 (kolliphor HS15 ) is safer for intravenous infusion than polysorbate 80,of the two intravenous curcumin solutions containing a solvent to prevent precipitation, one with DMSO and the other with ethanol, both containing kolliphor or similar.
@marcosbomber901 yes Marcos, you are right, thank you.
I usually used kolliphor ELP when required, although its nice to find ways around that.
polyvinylpyrrolidone is better but it is required in higher quantities. so kolliphor is the easiest to implement in this case.
Kind ergards,
Daniel
@marcosbomber901 I am interested in your thoughts on IV honokiol. This could have substantial treatment power; this could be our first metronomic OXPHOS inhibitor which could have large effects on cancer stem cells. It perhaps might not show up immediately on top line biomarkers, though knocking down cancer stem cells is of central importance in managing cancer. Do they even have a biomarker that measures cancer stem cell populations? We should, though, talk it through as there are quite a options here.
@jcancom @johan
I tried this johan and jcancon! I really haven't seen the expected results. Drawing conclusions in the three patients involved with mitohonokiol is not easy due to the extensive cocktail we use. Although I think that mitohonokiol correctly penetrates the brain because my mother has certain cognitive blocks when taking it.
There is one point that we always forget and this is the big difference from in vitro / in vivo studies later carried out in humans where metabolism is more complex.
Cancer has been "cured" hundreds of times in petri dishes ...
I am trying to convince my friend, the scientist at Enoc Pharma for a publication about his liposomes and why his method of formulating them prevents macrophages.
Enoc Pharma's liposomes are pharmaceutical grade so they can be used intravenously. We can think in intravenous administration of liposomal honokiol soon!
@manuone Hey manuel. The lipo formulations for intravenous route can be very effective if formulated well to avoid the take up by M but take care and be ready for allergic reactions. Make sure you have a solution for that in case that happens. Even better, use anti allergic prior to the IV.
Kind regards,
Daniel
@jcancom I do not know why J. It should work. Maybe the system assumes that when you already reached 4 stars, you don't need the edit option anymore 😀
Kind regards,
Daniel
@manuone , what I am thinking now is that IV honokiol could be more of a metronomic treatment. When taking honokiol orally or in another formulation one might only have a large one time dose (i.e., non-metronomic). What we have with IV HN is an opportunity to shut down OXPHOS over a prolonged period, this might give an entirely different response. We will need to be especially careful moving forward, as metronomic dosing as we have seen with 2-DG can be quite powerful.
@daniel , by the time one makes it up to be a four star contributor one might need the ability to edit all the more.
@manuone , I just read about your comment about liposomal honkiol. This is great! It is even better than the straight IV HN. I will be interested to see what might happen with magnolol or even 5-formylhonokiol lipsomes! I have also been thinking perhaps we could try chitosan honokiol. Liposomal formulations seem to be dosed nearly at the same level of straight chemical with only somewhat enhanced efficacy. With nano formulations with chitosan (e.g., nano methylglyoxal) we have seen ~400 fold dose reductions!
The figure that I posted previously shows a large effect of the honokiol and magnolol combination in mice brain cancer.
Very excited that others on forum can see the value in honokiol IV. Metronomic OXPHOS inhibition! Yeah!
@daniel, I posted again; again no edit button for me to edit my previous post!
I'ts odd, like J I never could find an edit until last night. Let's see now...
@jcancom @johan
I tried this johan and jcancon! I really haven't seen the expected results. Drawing conclusions in the three patients involved with mitohonokiol is not easy due to the extensive cocktail we use. Although I think that mitohonokiol correctly penetrates the brain because my mother has certain cognitive blocks when taking it.
Hi manuel,
From the study J mentioned , the difference in the effect between either compound alone, or in combination (HK + Magnolol) is significant.
I believe that a joint formulation for intravenous administration of honokiol and magnolol is possible since their solubility in ethanol is similar, their formulation would be similar to those of the two curcumin patents with kolliphor currently approved.
It should only be established if the ratio of magnolol honokiol is 1:1 or is a different ratio with a higher amount of honokiol.If the amount of honokiol was higher the solvent of choice would be DMSO because it can be infused faster and passes through virtually all membranes with ease.
Certainly as Manuone says mitohonokiol has not had the expected effects and in the case of my wife applied at a dose of 14 mg daily which is above the recommended dose of 10 mg
Perhaps the key is still the degradation suffered by the product, I do not know if intravenous mitohonokiol would be possible, or even if it has been tested in an animal trial.
This is a good starting point Marcos. I don't know if this is "safer" than with intravenous liposomes. I can't find any reference in humans
Hello, first of all thank Daniel and the community for the enormous help you provide in this crazy world of cancer.
I am Emilio, I am 30 years old, diagnosed in October 2019 with CIC-DUX4 round cell sarcoma (more aggressive and worse prognosis than Ewing) in the abductor muscle with a size of 16x16x8cm, with micronodules in the 2 lungs. At the moment, my health is good, I have lost a lot of weight due to a poorly made keto diet, and some muscle mass.
Start Vdc / IE scheme every 2 weeks, for 3 cycles, there was tumor progression. At this time my doctor makes a change in chemotherapy to the Ifosfamide-epiburicin protocol (3 + 2) every 3 weeks. At the moment I start oncothermia in primary tumor and lungs, Keto diet, and I visited Harguindey. CT scan after 3 cycles shows radiological tumor stability with slight progression.
A few days ago I finished the 6 maximum cycles of this chemo scheme, I am awaiting a new CT, my oncologist thinks of trabectedin + low-dose radiotherapy for my next treatment. He says I have no possible cure, and the treatments are to gain months of quality of life.
My genomic analysis shows positive for FANCA and PIK3CB.
My current drug treatment is taken by Harguindey and has been changing over time. Consists in:Liposomal amiloride 4ml x2
Amiloride capsules 10mg x5
Lansoprazole 30mg 5x
Acetazolamide 250mg 3x
Liposomal Quercetin 250mg 3x
Quercetin capsules 0.5gr 6x
Liposomal Reverastrol 400 mg 2x
Bicarbonate + DMSO 10ml 2x
Metformin 850mg 1x (waiting to rise due to possible interaction with amiloride)
Celecoxib 200mg 1x
Melatonia 200mg 1xI have also been in 2DG metronomic treatment for 5 weeks
Supplements that I have added and where I have most doubts.
Modified citrus pectin 5g - 1x.
Vitamin D3 5000IU -1x
Vitamin k2 100mcg -3x
Milk thistle 500mg -3x
Berberine 400mg -3x
Astragalus 500mg -2x
Corioulus Versicolor 500mg -6x
Omega 3 EPA 500mg and DHA 200mg -4x
Two-per-day Life extension -2x
In a few days I plan to add cannabis oil (Rick Simpson type), more than 1gr / dayI have many other supplements that you recommend, but I'm not sure how to use them to make the treatment effective. I put a list of them:
- Gree Tea Extract 850mg
- Alpha-Lipoic Acid 300mg
- Super Selenium Complex 200 mcg & Vitamin E
- Ashawagandha 1000mg
- High Potency Bromelain 3000GDU 500 mg
- Optizinc 30 mg
- Garcinia Cambogia 500mg
- 100% glycine powder
- 100% Methyl Sulfonyl Methane Powder
- Boswellia Serrata 2000mg
- Magnesium bisglycinate 500mg
- Liquid Curcumin NovaSol with vitamin D, 500 mg
- Black Garlic 2000mg
- Pure C8 MCT oilI have been entering the web and reading you for a while, but the more I read the more doubts arise and I see myself quite lost.
There isn't much information about sarcomas (or I can't find it) on the internet.
I am writing all this with the intention of explaining my case and, given your experience, seeing if you can help me make my treatment more effective or find evidence of sarcomas that I can use.
I'm quite desperate for my forecast.
Forgive me for my English, it's bad enough.Greetings to all and thanks
- Hi Emilio,
- my name is grace and my som has CICDUX4. We didn’t the COC protocol, with IV vitamin C, accupuncture, red light therapy, rso, and exercise induced oxygen therapy, during all of his treatments. We were only able to use the supplements and no off label prescription use.
- I was wondering if you could give an update on how you are doing and what you feel has worked for you.
- my son is 10 years old and his name is Dorian.
- thank you
