Notifications
Clear all

Treatment protocol sarcoma with mets  

Page 3 / 3
  RSS

johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 1:47 am  
Posted by: @daniel

@jcancom We could start with Salinomycin 😀 which is an antibiotic 

Talking about antibiotics....in this study adriamycin and lioposomal HK show synergistic antitumor effects.


Manuone and Daniel liked
ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 1:57 am  

we need an option to edit posts 😊 


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 2:15 am  

Highly Water-Soluble Solid Dispersions of Honokiol : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920775/


Daniel liked
ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 5 years ago
Posts: 777
29/06/2020 2:37 am  

@johan Honokiol, still, has a relatively good bio-availability and crosses brain blood barrier. But scientists are looking for ways to further improve its bio-availability. 

 

We have the edit option, 5 minutes after the post was published. After that, if its something annoying, please let me know and I will help with editing.

Kind regards,
Daniel


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 2:50 am  

Johan, it is so difficult to watch all of the research into metabolic treatments languish for years and years or realize that there were co-treatments lurking in plain sight that went unfound. When pharmaceutical companies advance a product through clinical trials, they typically would have spent years finding the best possible chemical, formulation etc. . Yet, with the treatments that we follow much of the research never seems to move forward. For example, research has found that 5-formylhonokiol is a more powerful form of honokiol, though we continue with honokiol. D notes that there is new evidence that magnesium can help with vitamin C. So much knowledge is beyond our awareness and it only emerges over the long term. If only we could integrate all of the knowledge, then very powerful treatments could emerge.


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 3:11 am  
Posted by: @daniel

 

We have the edit option, 5 minutes after the post was published. After that, if its something annoying, please let me know and I will help with editing.

Kind regards,
Daniel

I had no idea, J's typo revealed the need for this feature...my visits to hahnemann will never be the same now.


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 3:20 am  

Conversation is shifting around, though it is nice to see the vitality! Nebulizers? There has not been that much said on the forum about them. How helpful might this route of administration be with honokiol? Nebulizing could be an especially useful route for those with lung tumors, is this approach widely used?


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 3:22 am  

D when I post there is no edit button showing immediately afterwards. There does not appear to be an option to edit posts.


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 3:29 am  
Posted by: @jcancom

Conversation is shifting around, though it is nice to see the vitality! Nebulizers? There has not been that much said on the forum about them. How helpful might this route of administration be with honokiol? Nebulizing could be an especially useful route for those with lung tumors, is this approach widely used?

and transdermal: http://www.yydbzz.com/EN/10.3870/j.issn.1004-0781.2018.06.003


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 5:00 am  
Posted by: @jcancom

Johan, it is so difficult to watch all of the research into metabolic treatments languish for years and years or realize that there were co-treatments lurking in plain sight that went unfound. When pharmaceutical companies advance a product through clinical trials, they typically would have spent years finding the best possible chemical, formulation etc. . Yet, with the treatments that we follow much of the research never seems to move forward. 

J, I find it frustrating, there seems to be absolute lack of a sense of urgency. 


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
29/06/2020 7:35 am  
Posted by: @jcancom

D when I post there is no edit button showing immediately afterwards. There does not appear to be an option to edit posts.

J, we now have that option, Daniel must have enabled it just now as I was able to edit my last post. 


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 5 years ago
Posts: 777
29/06/2020 12:30 pm  

@johan Hi Johan, it was always enabled, at least for the past year. I did not change anything now. Probably J did not see yet the option.

Kind regards,
Daniel


ReplyQuote
marcosbomber901
(@marcosbomber901)
Eminent Member
Joined: 3 years ago
Posts: 90
29/06/2020 4:42 pm  

@daniel

I think solutol HS15 (kolliphor HS15 ) is safer for intravenous infusion than polysorbate 80,of the two intravenous curcumin solutions containing a solvent to prevent precipitation, one with DMSO and the other with ethanol, both containing kolliphor or similar.


ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 5 years ago
Posts: 777
29/06/2020 5:57 pm  

@marcosbomber901 yes Marcos, you are right, thank you.

I usually used kolliphor ELP when required, although its nice to find ways around that.

polyvinylpyrrolidone is better but it is required in higher quantities. so kolliphor is the easiest to implement in this case.

Kind ergards,

Daniel


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 9:47 pm  

@marcosbomber901 I am interested in your thoughts on IV honokiol. This could have substantial treatment power; this could be our first metronomic OXPHOS inhibitor which could have large effects on cancer stem cells. It perhaps might not show up immediately on top line biomarkers, though knocking down cancer stem cells is of central importance in managing cancer. Do they even have a biomarker that measures cancer stem cell populations? We should, though, talk it through as there are quite a options here.


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 9:49 pm  

@daniel, I posted again; again no edit button for me to edit my previous post! 


ReplyQuote
Manuone
(@manuone)
Trusted Member
Joined: 2 years ago
Posts: 111
29/06/2020 10:31 pm  

@jcancom @johan

I tried this johan and jcancon! I really haven't seen the expected results. Drawing conclusions in the three patients involved with mitohonokiol is not easy due to the extensive cocktail we use. Although I think that mitohonokiol correctly penetrates the brain because my mother has certain cognitive blocks when taking it.
There is one point that we always forget and this is the big difference from in vitro / in vivo studies later carried out in humans where metabolism is more complex.
Cancer has been "cured" hundreds of times in petri dishes ...
I am trying to convince my friend, the scientist at Enoc Pharma for a publication about his liposomes and why his method of formulating them prevents macrophages.
Enoc Pharma's liposomes are pharmaceutical grade so they can be used intravenously. We can think in  intravenous administration of liposomal honokiol soon!


johan liked
ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 5 years ago
Posts: 777
29/06/2020 10:53 pm  

@manuone Hey manuel. The lipo formulations for intravenous route can be very effective if formulated well to avoid the take up by M but take care and be ready for allergic reactions. Make sure you have a solution for that in case that happens. Even better, use anti allergic prior to the IV.

Kind regards,
Daniel


Manuone liked
ReplyQuote
Daniel
(@daniel)
Member Admin
Joined: 5 years ago
Posts: 777
29/06/2020 10:54 pm  

@jcancom I do not know why J. It should work. Maybe the system assumes that when you already reached 4 stars, you don't need the edit option anymore 😀

Kind regards,
Daniel


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 11:10 pm  

@manuone , what I am thinking now is that IV honokiol could be more of a metronomic treatment. When taking honokiol orally or in another formulation one might only have a large one time dose (i.e., non-metronomic). What we have with IV HN is an opportunity to shut down OXPHOS over a prolonged period, this might give an entirely different response. We will need to be especially careful moving forward, as metronomic dosing as we have seen with 2-DG can be quite powerful. 


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 11:11 pm  

@daniel  , by the time one makes it up to be a four star contributor one might need the ability to edit all the more.


ReplyQuote
Jcancom
(@jcancom)
Estimable Member
Joined: 3 years ago
Posts: 345
29/06/2020 11:39 pm  

@manuone , I just read about your comment about liposomal honkiol. This is great! It is even better than the straight IV HN. I will be interested to see what might happen with magnolol or even 5-formylhonokiol lipsomes! I have also been thinking perhaps we could try chitosan honokiol. Liposomal formulations seem to be dosed nearly at the same level of straight chemical with only somewhat enhanced efficacy. With nano formulations with chitosan (e.g., nano methylglyoxal) we have seen ~400 fold dose reductions!

The figure that I posted previously shows a large effect of the honokiol and magnolol combination in mice brain cancer.

Very excited that others on forum can see the value in honokiol IV. Metronomic OXPHOS inhibition! Yeah!

 


johan liked
ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
30/06/2020 2:38 am  
Posted by: @jcancom

@daniel, I posted again; again no edit button for me to edit my previous post! 

I'ts odd, like J I never could find an edit until last night. Let's see now...


ReplyQuote
johan
(@johan)
Estimable Member
Joined: 2 years ago
Posts: 450
30/06/2020 3:08 am  
Posted by: @manuone

@jcancom @johan

I tried this johan and jcancon! I really haven't seen the expected results. Drawing conclusions in the three patients involved with mitohonokiol is not easy due to the extensive cocktail we use. Although I think that mitohonokiol correctly penetrates the brain because my mother has certain cognitive blocks when taking it.

Hi manuel,

From the study J mentioned , the difference in the effect between either compound alone, or in combination (HK + Magnolol) is significant. 


ReplyQuote
marcosbomber901
(@marcosbomber901)
Eminent Member
Joined: 3 years ago
Posts: 90
30/06/2020 10:49 am  

I believe that a joint formulation for intravenous administration of honokiol and magnolol is possible since their solubility in ethanol is similar, their formulation would be similar to those of the two curcumin patents with kolliphor currently approved.

It should only be established if the ratio of magnolol honokiol is 1:1 or is a different ratio with a higher amount of honokiol.If the amount of honokiol was higher the solvent of choice would be DMSO because it can be infused faster and passes through virtually all membranes with ease.


Manuone and johan liked
ReplyQuote
marcosbomber901
(@marcosbomber901)
Eminent Member
Joined: 3 years ago
Posts: 90
30/06/2020 10:52 am  

Certainly as Manuone says mitohonokiol has not had the expected effects and in the case of my wife applied at a dose of 14 mg daily which is above the recommended dose of 10 mg


ReplyQuote
marcosbomber901
(@marcosbomber901)
Eminent Member
Joined: 3 years ago
Posts: 90
30/06/2020 10:55 am  

Perhaps the key is still the degradation suffered by the product, I do not know if intravenous mitohonokiol would be possible, or even if it has been tested in an animal trial.


ReplyQuote
Manuone
(@manuone)
Trusted Member
Joined: 2 years ago
Posts: 111
30/06/2020 7:14 pm  

@marcosbomber901

This is a good starting point Marcos. I don't know if this is "safer" than with intravenous liposomes. I can't find any reference in humans


ReplyQuote
Page 3 / 3
Share: